Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

doi:10.1007/s13659-022-00344-1

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (4): 24-24.DOI: 10.1007/s13659-022-00344-1

• Original Article • Previous Articles Next Articles

Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Guang-Xing Yu^1,2, Jing Wu¹, Bao-Bao Shi¹, Mei-Fen Bao¹, Xiang-Hai Cai¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100039, People's Republic of China

Received:2022-03-28 Online:2022-08-12 Published:2022-08-24
Contact: Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
Supported by:
This project was funded in part by the National Natural Science Foundation of China (No. 31872677).

Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Guang-Xing Yu^1,2, Jing Wu¹, Bao-Bao Shi¹, Mei-Fen Bao¹, Xiang-Hai Cai¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100039, People's Republic of China

通讯作者: Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
基金资助:
This project was funded in part by the National Natural Science Foundation of China (No. 31872677).

Abstract

Abstract: Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.

Key words: Cephalotaxus oliveri, Cephalotaxaceae, Alkaloid, Enantiomer

摘要： Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.

关键词: Cephalotaxus oliveri, Cephalotaxaceae, Alkaloid, Enantiomer

Guang-Xing Yu, Jing Wu, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri[J]. Natural Products and Bioprospecting, 2022, 12(4): 24-24.

Guang-Xing Yu, Jing Wu, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri[J]. 应用天然产物, 2022, 12(4): 24-24.

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Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

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