Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

doi:10.1007/s13659-020-00294-6

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (1): 127-135.DOI: 10.1007/s13659-020-00294-6

• ORIGINAL ARTICLES • Previous Articles Next Articles

Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

Yun-Li Zhao^1,2, Zhong-Ping Gou³, Jian-Hua Shang², Wan-Yi Li⁴, Yu Kuang⁴, Ming-Yuan Li⁴, Xiao-Dong Luo^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education;Yunnan Provincial Center for Research & Development of Natural Products;School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China;
3 Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu 610041, China;
4 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China

Received:2020-11-12 Revised:2020-12-15 Online:2021-03-11 Published:2021-02-24
Contact: Ming-Yuan Li, Xiao-Dong Luo
Supported by:
The authors are grateful to the general program of applied basic research of Yunnan province (2019FB116) and the National Key Research and Development Program of China (2017YFC1704007) for partly financial support.

Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

Yun-Li Zhao^1,2, Zhong-Ping Gou³, Jian-Hua Shang², Wan-Yi Li⁴, Yu Kuang⁴, Ming-Yuan Li⁴, Xiao-Dong Luo^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education;Yunnan Provincial Center for Research & Development of Natural Products;School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China;
3 Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu 610041, China;
4 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China

通讯作者: Ming-Yuan Li, Xiao-Dong Luo
基金资助:
The authors are grateful to the general program of applied basic research of Yunnan province (2019FB116) and the National Key Research and Development Program of China (2017YFC1704007) for partly financial support.

Abstract

Abstract: Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment respiratory infections.

Key words: Alstonia scholaris, Total alkaloids, Acute respiratory infections, Anti-virus, Anti-bacteria

摘要： Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment respiratory infections.

关键词: Alstonia scholaris, Total alkaloids, Acute respiratory infections, Anti-virus, Anti-bacteria

Yun-Li Zhao, Zhong-Ping Gou, Jian-Hua Shang, Wan-Yi Li, Yu Kuang, Ming-Yuan Li, Xiao-Dong Luo. Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris[J]. Natural Products and Bioprospecting, 2021, 11(1): 127-135.

Yun-Li Zhao, Zhong-Ping Gou, Jian-Hua Shang, Wan-Yi Li, Yu Kuang, Ming-Yuan Li, Xiao-Dong Luo. Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris[J]. 应用天然产物, 2021, 11(1): 127-135.

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Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

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