Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

doi:10.1007/s13659-022-00327-2

Natural Products and Bioprospecting ›› 2022, Vol. 12 ›› Issue (1): 1-5.DOI: 10.1007/s13659-022-00327-2

• ORIGINAL ARTICLES •

Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Pan-Pan Wei, Jia-Cheng Ji, Xu-Jun Ma, Zheng-Hui Li, Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

Received:2021-09-04 Revised:2021-11-08 Online:2022-03-12 Published:2022-02-24
Contact: Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu
Supported by:
National Natural Science Foundation of China (31870513), Zheng-Hui Li, National Aerospace Science Foundation of China (32000011), Hong-Lian Ai.

Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Pan-Pan Wei, Jia-Cheng Ji, Xu-Jun Ma, Zheng-Hui Li, Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

通讯作者: Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu
基金资助:
National Natural Science Foundation of China (31870513), Zheng-Hui Li, National Aerospace Science Foundation of China (32000011), Hong-Lian Ai.

Abstract

Abstract: Three new pyrrole alkaloids albifipyrrols A-C (1-3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC₅₀ value 16.16 μM.

Key words: Pyrrole alkaloids, Coptis chinensis, Endophytic fungus, Albifimbria viridis, Immunosuppressive activity

摘要： Three new pyrrole alkaloids albifipyrrols A-C (1-3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC₅₀ value 16.16 μM.

关键词: Pyrrole alkaloids, Coptis chinensis, Endophytic fungus, Albifimbria viridis, Immunosuppressive activity

Pan-Pan Wei, Jia-Cheng Ji, Xu-Jun Ma, Zheng-Hui Li, Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu. Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis[J]. Natural Products and Bioprospecting, 2022, 12(1): 1-5.

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Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

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