Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

doi:10.1007/s13659-026-00613-3

Natural Products and Bioprospecting ›› 2026, Vol. 16 ›› Issue (4): 59-59.DOI: 10.1007/s13659-026-00613-3

• ORIGINAL ARTICLES • Previous Articles Next Articles

Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

Peng-Ju Xu¹, Ai-Lin Liang¹, Wen-Yu Lu¹, Hong-Ping Long³, Qing-Hui Xiao², Qi-An Chen¹, Meng-Lan Hu¹, Ngoc Nhu Thao Nguyen¹, Shao Liu², Jing Li^1,2, Wen-Xuan Wang¹

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, People's Republic of China;
2. Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China;
3. Center for Medical Research and Innovation, the First Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China

Received:2025-12-20 Accepted:2026-02-23 Online:2026-08-29 Published:2026-08-22
Contact: Jing Li,E-mail:lijingliyun@csu.edu.cn;Wen-Xuan Wang,E-mail:wangwenxuan@csu.edu.cn
Supported by:
The work was financially supported by National Natural Science Foundation of China (No. 82173713), Natural Science Foundation of Hunan Province (No. 2024JJ8127), Changsha Municipal Natural Science Foundation (No. kq2403041), Hunan Provincial Administration of Traditional Chinese Medicine (No. B2023059), and Fundamental Research Funds for the Central Universities of Central South University (No. 2024ZZTS0990, 2025ZZTS0913).

Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

Peng-Ju Xu¹, Ai-Lin Liang¹, Wen-Yu Lu¹, Hong-Ping Long³, Qing-Hui Xiao², Qi-An Chen¹, Meng-Lan Hu¹, Ngoc Nhu Thao Nguyen¹, Shao Liu², Jing Li^1,2, Wen-Xuan Wang¹

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, People's Republic of China;
2. Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China;
3. Center for Medical Research and Innovation, the First Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China

通讯作者: Jing Li,E-mail:lijingliyun@csu.edu.cn;Wen-Xuan Wang,E-mail:wangwenxuan@csu.edu.cn
基金资助:
The work was financially supported by National Natural Science Foundation of China (No. 82173713), Natural Science Foundation of Hunan Province (No. 2024JJ8127), Changsha Municipal Natural Science Foundation (No. kq2403041), Hunan Provincial Administration of Traditional Chinese Medicine (No. B2023059), and Fundamental Research Funds for the Central Universities of Central South University (No. 2024ZZTS0990, 2025ZZTS0913).

Abstract

Abstract: Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (3), and seven new trichothecene sesquiterpenoids, trichothecrotocins T-Z (4-10), together with three new natural products (11-13) and thirteen known compounds (14-26), were isolated from the soil fungus Trichothecium sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds 7 and 8 induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.

Key words: Trichothecenes, Trichothecium sp., Secondary metabolite, Cytotoxic activity

摘要： Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (3), and seven new trichothecene sesquiterpenoids, trichothecrotocins T-Z (4-10), together with three new natural products (11-13) and thirteen known compounds (14-26), were isolated from the soil fungus Trichothecium sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds 7 and 8 induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.

关键词: Trichothecenes, Trichothecium sp., Secondary metabolite, Cytotoxic activity

Peng-Ju Xu, Ai-Lin Liang, Wen-Yu Lu, Hong-Ping Long, Qing-Hui Xiao, Qi-An Chen, Meng-Lan Hu, Ngoc Nhu Thao Nguyen, Shao Liu, Jing Li, Wen-Xuan Wang. Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815[J]. Natural Products and Bioprospecting, 2026, 16(4): 59-59.

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Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

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