Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review

doi:10.1007/s13659-025-00531-w

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (5): 47-47.DOI: 10.1007/s13659-025-00531-w

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Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review

Ni Wayan Martiningsih^1,2, Siska Elisahbet Sinaga³, Wahyu Safriansyah¹, Unang Supratman^1,4, Desi Harneti¹

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Sumedang, West Java, Indonesia;
2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha, Singaraja, 81116, Bali, Indonesia;
3. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;
4. Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Sumedang, West Java, Indonesia

Received:2025-03-10 Online:2025-11-06
Contact: Desi Harneti,E-mail:desi.harneti@unpad.ac.id
Supported by:
Universitas Padjadjaran,2355/UN6.3.1/PT.00/2024,Desi Harneti,Lembaga Pengelola Dana Pendidikan,20230721199879,Ni Wayan Martiningsih

Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review

Ni Wayan Martiningsih^1,2, Siska Elisahbet Sinaga³, Wahyu Safriansyah¹, Unang Supratman^1,4, Desi Harneti¹

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Sumedang, West Java, Indonesia;
2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha, Singaraja, 81116, Bali, Indonesia;
3. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;
4. Central Laboratory, Universitas Padjadjaran, Jatinangor, 45363, Sumedang, West Java, Indonesia

通讯作者: Desi Harneti,E-mail:desi.harneti@unpad.ac.id
基金资助:
Universitas Padjadjaran,2355/UN6.3.1/PT.00/2024,Desi Harneti,Lembaga Pengelola Dana Pendidikan,20230721199879,Ni Wayan Martiningsih

Abstract

Abstract: The Meliaceae family, widely distributed in tropical and subtropical regions, has been traditionally used for medicinal purposes, particularly in treating infections and inflammatory diseases. The objective of this study is to provide a comprehensive account of the nitrogen-containing secondary metabolites and their biological activities that have been isolated from the Meliaceae family between the years 1979 and 2024. Studies on nitrogen-containing compounds of the Meliaceae family were collected and analyzed using data from SciFinder, PubMed, Google Scholar, Scopus and World Flora Online. Over the course of more than four decades, numerous studies have been conducted on a variety of plant parts, including twigs, stems, barks, roots, fruits, seeds, and leaves. These studies have identified approximately 326 compounds belonging to diverse chemical groups, such as alkaloids, limonoids, triterpenoids, and nitrogen-containing flavaglines being the largest group of natural products, comprising 118 compounds (36.2%). Several compounds have been evaluated for insecticidal, anti-inflammatory, molluscicide, antibacterial, antimalarial, tyrosinase inhibition, osteoclast differentiation inhibition, and α-glucosidase inhibition activity. The systematic classification and analysis of these compounds provide insights into their biosynthesis and bioactivities, paving the way for future drug development.

Key words: Nitrogen-containing, Secondary metabolites, Meliaceae, Biological activity

摘要： The Meliaceae family, widely distributed in tropical and subtropical regions, has been traditionally used for medicinal purposes, particularly in treating infections and inflammatory diseases. The objective of this study is to provide a comprehensive account of the nitrogen-containing secondary metabolites and their biological activities that have been isolated from the Meliaceae family between the years 1979 and 2024. Studies on nitrogen-containing compounds of the Meliaceae family were collected and analyzed using data from SciFinder, PubMed, Google Scholar, Scopus and World Flora Online. Over the course of more than four decades, numerous studies have been conducted on a variety of plant parts, including twigs, stems, barks, roots, fruits, seeds, and leaves. These studies have identified approximately 326 compounds belonging to diverse chemical groups, such as alkaloids, limonoids, triterpenoids, and nitrogen-containing flavaglines being the largest group of natural products, comprising 118 compounds (36.2%). Several compounds have been evaluated for insecticidal, anti-inflammatory, molluscicide, antibacterial, antimalarial, tyrosinase inhibition, osteoclast differentiation inhibition, and α-glucosidase inhibition activity. The systematic classification and analysis of these compounds provide insights into their biosynthesis and bioactivities, paving the way for future drug development.

关键词: Nitrogen-containing, Secondary metabolites, Meliaceae, Biological activity

Ni Wayan Martiningsih, Siska Elisahbet Sinaga, Wahyu Safriansyah, Unang Supratman, Desi Harneti. Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review[J]. Natural Products and Bioprospecting, 2025, 15(5): 47-47.

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Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review

Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review

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