Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

doi:10.1007/s13659-024-00494-4

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (1): 9-9.DOI: 10.1007/s13659-024-00494-4

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Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

Dong-Yang Wang^1,2, Ming-Xing Li^1,2, Yan-Chao Xu^1,3, Peng Fu⁴, Wei-Ming Zhu^1,4, Li-Ping Wang^1,2

1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China;
2. Natural Product Research Center of Guizhou Province, Guiyang, 550014, China;
3. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 561113, China;
4. School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China

Received:2024-09-22 Accepted:2024-12-27 Online:2025-02-15 Published:2025-02-24
Contact: Wei-Ming ZHU,E-mail:weimingzhu@ouc.edu.cn;Li-Ping WANG,E-mail:wangliping2022@gmc.edu.cn
Supported by:
The National Natural Science Foundation of China,82460684,Li-Ping Wang, West Light Foundation, Chinese Academy of Sciences, RZ [2022]4, Li-Ping Wang, Research Foundation for Advanced Talents (D. Wang),TCZJZ [2022]02, Dong-Yang Wang, Project of State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, QJJ[2022]419, Peng Fu, Cultivation project of National Natural Science Foundation of Guizhou Medical University, 20NSP065, Li-Ping Wang, the 100 Leading Talents of Guizhou Province, W. Zhu, Wei-Ming Zhu.

Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

Dong-Yang Wang^1,2, Ming-Xing Li^1,2, Yan-Chao Xu^1,3, Peng Fu⁴, Wei-Ming Zhu^1,4, Li-Ping Wang^1,2

1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China;
2. Natural Product Research Center of Guizhou Province, Guiyang, 550014, China;
3. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 561113, China;
4. School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China

通讯作者: Wei-Ming ZHU,E-mail:weimingzhu@ouc.edu.cn;Li-Ping WANG,E-mail:wangliping2022@gmc.edu.cn
基金资助:
The National Natural Science Foundation of China,82460684,Li-Ping Wang, West Light Foundation, Chinese Academy of Sciences, RZ [2022]4, Li-Ping Wang, Research Foundation for Advanced Talents (D. Wang),TCZJZ [2022]02, Dong-Yang Wang, Project of State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, QJJ[2022]419, Peng Fu, Cultivation project of National Natural Science Foundation of Guizhou Medical University, 20NSP065, Li-Ping Wang, the 100 Leading Talents of Guizhou Province, W. Zhu, Wei-Ming Zhu.

Abstract

Abstract: A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1-11). Notably, the newly identified dibohemamines I–O (1-7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24±0.20 and 7.36±0.41 μM, respectively.

Key words: Endophytic actinomycete, Secondary metabolite, Dibohemamine, Cytotoxicity

摘要： A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1-11). Notably, the newly identified dibohemamines I–O (1-7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24±0.20 and 7.36±0.41 μM, respectively.

关键词: Endophytic actinomycete, Secondary metabolite, Dibohemamine, Cytotoxicity

Dong-Yang Wang, Ming-Xing Li, Yan-Chao Xu, Peng Fu, Wei-Ming Zhu, Li-Ping Wang. Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.[J]. Natural Products and Bioprospecting, 2025, 15(1): 9-9.

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Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

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