Four New Limonoids from the Barks of Toona ciliata

doi:10.1007/s13659-020-00274-w

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (1): 81-86.DOI: 10.1007/s13659-020-00274-w

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Four New Limonoids from the Barks of Toona ciliata

Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China

Received:2020-08-21 Revised:2020-10-12 Online:2021-03-11 Published:2021-02-24
Contact: Jun Luo, Ling-Yi Kong
Supported by:
Financial supports for this study were from the National Natural Science Foundation of China (31470416), the National New Drug Innovation Major Project (2018ZX09711-001-007), the National Key R&D Program of China (2018YFC1707105), and the "Double First-Class" University project (CPU2018GY08, China).

Four New Limonoids from the Barks of Toona ciliata

Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China

通讯作者: Jun Luo, Ling-Yi Kong
基金资助:
Financial supports for this study were from the National Natural Science Foundation of China (31470416), the National New Drug Innovation Major Project (2018ZX09711-001-007), the National Key R&D Program of China (2018YFC1707105), and the "Double First-Class" University project (CPU2018GY08, China).

Abstract

Abstract: Four new limonoids, toonayunnanaes F-I (1-4), and six known compounds (5-10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC₅₀ 38.45±0.41 μM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

Key words: Meliaceae, Toona ciliate, Limonoids, NO inhibitory effects

摘要： Four new limonoids, toonayunnanaes F-I (1-4), and six known compounds (5-10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC₅₀ 38.45±0.41 μM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

关键词: Meliaceae, Toona ciliate, Limonoids, NO inhibitory effects

Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong. Four New Limonoids from the Barks of Toona ciliata[J]. Natural Products and Bioprospecting, 2021, 11(1): 81-86.

Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong. Four New Limonoids from the Barks of Toona ciliata[J]. 应用天然产物, 2021, 11(1): 81-86.

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Four New Limonoids from the Barks of Toona ciliata

Four New Limonoids from the Barks of Toona ciliata

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