Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2020, Vol. 10 ›› Issue (1): 45-49.DOI: 10.1007/s13659-020-00233-5

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity

Xin-Yu Jia1, Yong-Mei Wu2, Jing-Ya Li2, Chun Lei1, Ai-Jun Hou1   

  1. 1 School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China;
    2 National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • Received:2020-01-14 Revised:2020-02-06 Online:2020-02-29 Published:2020-02-24
  • Contact: Chun Lei, Ai-Jun Hou
  • Supported by:
    Financial supports from the National Natural Science Foundation of China (Grant Nos. 81222045 and 21672040) and the Drug Innovation Major Project of China (Grant No. 2018ZX09735001-002-006) are gratefully acknowledged.

Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity

Xin-Yu Jia1, Yong-Mei Wu2, Jing-Ya Li2, Chun Lei1, Ai-Jun Hou1   

  1. 1 School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China;
    2 National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 通讯作者: Chun Lei, Ai-Jun Hou
  • 基金资助:
    Financial supports from the National Natural Science Foundation of China (Grant Nos. 81222045 and 21672040) and the Drug Innovation Major Project of China (Grant No. 2018ZX09735001-002-006) are gratefully acknowledged.

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Abstract: Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC50 value of 0.52±0.11 μM.

Key words: Ficus hispida, Moraceae, Alkaloids, Antiinflammation, Nuclear factor-κB

摘要： Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC50 value of 0.52±0.11 μM.

关键词: Ficus hispida, Moraceae, Alkaloids, Antiinflammation, Nuclear factor-κB

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