Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng

doi:10.1007/s13659-018-0171-0

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (5): 391-396.DOI: 10.1007/s13659-018-0171-0

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Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng

Wen-Jie Sun^1,2, Hong-Tao Zhu¹, Tian-Yuan Zhang³, Meng-Yue Zhang³, Dong Wang¹, Chong-Ren Yang¹, Yi-Xuan Zhang³, Ying-Jun Zhang^1,4

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China

Received:2018-04-18 Revised:2018-05-28 Online:2018-09-19 Published:2018-10-24
Contact: Yi-Xuan Zhang, Ying-Jun Zhang
Supported by:
This work was supported by the Major Science and Technique Programs in Yunnan Province (2016ZF001-001, 2017IB038), the Science and Technology Planning Project of Yunnan Province (2013FC008, 2015IC017) and the National Science and Technology Major Project of China (2018ZX09735001-002-002).

Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng

Wen-Jie Sun^1,2, Hong-Tao Zhu¹, Tian-Yuan Zhang³, Meng-Yue Zhang³, Dong Wang¹, Chong-Ren Yang¹, Yi-Xuan Zhang³, Ying-Jun Zhang^1,4

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China

通讯作者: Yi-Xuan Zhang, Ying-Jun Zhang
基金资助:
This work was supported by the Major Science and Technique Programs in Yunnan Province (2016ZF001-001, 2017IB038), the Science and Technology Planning Project of Yunnan Province (2013FC008, 2015IC017) and the National Science and Technology Major Project of China (2018ZX09735001-002-002).

Abstract

Abstract: Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and[-(α-oxyisohexanoyl-N-methyl-leucyl)₂-] (2), together with two known ones, (-)-oxysporidinone (3) and (-)-4,6'-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses. Compounds 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line, and the new compound 2 showed significant inhibitory activity on NO production with the IC₅₀ value of 18.10 ±0.16 μM.

Key words: Fusarium tricinctum SYPF 7082, Endophytic fungus, Alkaloids, Panax notoginseng, Inhibition on NO production

摘要： Panax notoginseng (Araliaceae) is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of China. Two new alkaloids, rigidiusculamide E (1) and[-(α-oxyisohexanoyl-N-methyl-leucyl)₂-] (2), together with two known ones, (-)-oxysporidinone (3) and (-)-4,6'-anhydrooxysporidinone (4) were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082, an endophytic fungus obtained from the healthy root of P. notoginseng. Their structures were determined on the basis of extensive spectroscopic analyses. Compounds 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line, and the new compound 2 showed significant inhibitory activity on NO production with the IC₅₀ value of 18.10 ±0.16 μM.

关键词: Fusarium tricinctum SYPF 7082, Endophytic fungus, Alkaloids, Panax notoginseng, Inhibition on NO production

Wen-Jie Sun, Hong-Tao Zhu, Tian-Yuan Zhang, Meng-Yue Zhang, Dong Wang, Chong-Ren Yang, Yi-Xuan Zhang, Ying-Jun Zhang. Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng[J]. Natural Products and Bioprospecting, 2018, 8(5): 391-396.

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Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng

Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng

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