Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

doi:10.1007/s13659-025-00503-0

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (3): 22-22.DOI: 10.1007/s13659-025-00503-0

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Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

Wei-Ye Wu¹, Xun Wei¹, Qiong Liao², Yi-Fan Fu¹, Lei-Ming Wu¹, Lei Li¹, Shu-Qi Wu¹, Qing-Ren Lu¹, Fang-Yu Yuan¹, Dong Huang¹, Zhang-Hua Sun³, Tao Yuan⁴, Gui-Hua Tang¹

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China;
2. Laboratory Animal Center, Sun Yat-sen University, Guangzhou, 510006, China;
3. Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan, 512005, China;
4. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China

Received:2025-01-15 Accepted:2025-03-05 Online:2025-06-18 Published:2025-06-24
Supported by:
This work was supported by the Science and Technology Program of Guangzhou, China (No. 2024B03J1322), the Science and Technology Planning Project of Guangdong Province, China (No. 2023A1111120025), the National Natural Science Foundation of China (Nos. 82404454 and 22407144), and the Guangdong Basic and Applied Basic Research Foundation, China (No. 2021B1515140062).

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

Wei-Ye Wu¹, Xun Wei¹, Qiong Liao², Yi-Fan Fu¹, Lei-Ming Wu¹, Lei Li¹, Shu-Qi Wu¹, Qing-Ren Lu¹, Fang-Yu Yuan¹, Dong Huang¹, Zhang-Hua Sun³, Tao Yuan⁴, Gui-Hua Tang¹

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China;
2. Laboratory Animal Center, Sun Yat-sen University, Guangzhou, 510006, China;
3. Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan, 512005, China;
4. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China

通讯作者: Gui-Hua Tang Email:E-mail:tanggh5@mail.sysu.edu.cn
基金资助:
This work was supported by the Science and Technology Program of Guangzhou, China (No. 2024B03J1322), the Science and Technology Planning Project of Guangdong Province, China (No. 2023A1111120025), the National Natural Science Foundation of China (Nos. 82404454 and 22407144), and the Guangdong Basic and Applied Basic Research Foundation, China (No. 2021B1515140062).

Abstract

Abstract: A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC₅₀ value of 4.24±0.13 μM, more than the positive control drug (12.99±0.13 μM).

Key words: Endophytic fungus, Penicillium canescens, Polyketides, Alkaloids, Cytotoxic activity

摘要： A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC₅₀ value of 4.24±0.13 μM, more than the positive control drug (12.99±0.13 μM).

关键词: Endophytic fungus, Penicillium canescens, Polyketides, Alkaloids, Cytotoxic activity

Wei-Ye Wu, Xun Wei, Qiong Liao, Yi-Fan Fu, Lei-Ming Wu, Lei Li, Shu-Qi Wu, Qing-Ren Lu, Fang-Yu Yuan, Dong Huang, Zhang-Hua Sun, Tao Yuan, Gui-Hua Tang. Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1[J]. Natural Products and Bioprospecting, 2025, 15(3): 22-22.

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Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

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