Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis

doi:10.1007/s13659-025-00562-3

Natural Products and Bioprospecting ›› 2026, Vol. 16 ›› Issue (1): 9-9.DOI: 10.1007/s13659-025-00562-3

• Original Article • Previous Articles Next Articles

Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis

Yun Liu¹, Jian-Qiang Zhao¹, Yan-Long Yang², Han-Bing Yuan¹, Yan-Ming Wang^1,3,4, Jun Yuan^1,3,4

1. Jiangsu Key Laboratory of Regional Specific Resource Pharmaceutical Transformation, Huaiyin Institute of Technology, Huai'an 223003, China;
2. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;
3. National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huai'an 223003, China;
4. Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, China

Received:2025-07-21 Online:2026-03-25 Published:2026-02-14
Contact: Yan-Ming Wang,E-mail:823113328@qq.com;Jun Yuan,E-mail:yuanj_hyit@163.com
Supported by:
This work was supported by Major Program of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province of China (No. 24KJA360001) and Open Project of Jiangsu Provincial Key Laboratory of Palygorskite Science and Applied Technology (No. HPZ202402).

Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis

Yun Liu¹, Jian-Qiang Zhao¹, Yan-Long Yang², Han-Bing Yuan¹, Yan-Ming Wang^1,3,4, Jun Yuan^1,3,4

1. Jiangsu Key Laboratory of Regional Specific Resource Pharmaceutical Transformation, Huaiyin Institute of Technology, Huai'an 223003, China;
2. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;
3. National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huai'an 223003, China;
4. Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, China

通讯作者: Yan-Ming Wang,E-mail:823113328@qq.com;Jun Yuan,E-mail:yuanj_hyit@163.com
基金资助:
This work was supported by Major Program of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province of China (No. 24KJA360001) and Open Project of Jiangsu Provincial Key Laboratory of Palygorskite Science and Applied Technology (No. HPZ202402).

Abstract

Abstract: A chemical constituent study on the fermented rice substrate of basidiomycetous fungus Panus rudis led to the isolation of four previously undescribed prenylhydroquinone derivatives compounds (1-4) and eight known compounds (5-12). Among them, compound 3 featured a rare benzothiazole derivative with hydroxy substituted 3-methyl-1-butenyl substitution on the benzene ring, and the absolute configurations of 7 and 12 were elucidated as unreported ones. Their structures were identified by the interpretation of 1D and 2D NMR spectroscopy, HRESIMS data, X-ray single-crystal diffraction, and comparison of calculated and experimental ECD spectra. The plausible biosynthetic pathways for 1-7 are proposed. Cytotoxicity evaluation was conducted on 1 and 3-12 against two cancer cell lines (A-549 and HepG2). The results demonstrated that 1, 3-6, 8, 9, and 12 exhibited weak cytotoxicity against both two cell lines. Among them, 8 and 12 showed dose-dependent inhibitory effects, and their IC₅₀ values at 72 h were obtained.

Key words: Panus rudis, Solid-state fermentation, Benzothiazole derivatives, Cytotoxicity

摘要： A chemical constituent study on the fermented rice substrate of basidiomycetous fungus Panus rudis led to the isolation of four previously undescribed prenylhydroquinone derivatives compounds (1-4) and eight known compounds (5-12). Among them, compound 3 featured a rare benzothiazole derivative with hydroxy substituted 3-methyl-1-butenyl substitution on the benzene ring, and the absolute configurations of 7 and 12 were elucidated as unreported ones. Their structures were identified by the interpretation of 1D and 2D NMR spectroscopy, HRESIMS data, X-ray single-crystal diffraction, and comparison of calculated and experimental ECD spectra. The plausible biosynthetic pathways for 1-7 are proposed. Cytotoxicity evaluation was conducted on 1 and 3-12 against two cancer cell lines (A-549 and HepG2). The results demonstrated that 1, 3-6, 8, 9, and 12 exhibited weak cytotoxicity against both two cell lines. Among them, 8 and 12 showed dose-dependent inhibitory effects, and their IC₅₀ values at 72 h were obtained.

关键词: Panus rudis, Solid-state fermentation, Benzothiazole derivatives, Cytotoxicity

Yun Liu, Jian-Qiang Zhao, Yan-Long Yang, Han-Bing Yuan, Yan-Ming Wang, Jun Yuan. Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis[J]. Natural Products and Bioprospecting, 2026, 16(1): 9-9.

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Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis

Panunoids A-D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis

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