Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

doi:10.1007/s13659-025-00563-2

Abstract

Abstract: Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 μM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 μM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induced PC12 cell death with EC₅₀ values ranging from 1.16 to 1.74 μM. Compound 22 exhibited the most significant inhibitory activity among the isolates against nitric oxide (NO) release in lipopolysaccharide (LPS)-activated BV2 cells with an IC₅₀ value of 22.41 μM.

Key words: Aglaia odorata Lour., Diterpenoids, Triterpenoids, Anti-neuroinflammation, Anti-ferroptosis, Neuroprotective activity

摘要： Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 μM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 μM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induced PC12 cell death with EC₅₀ values ranging from 1.16 to 1.74 μM. Compound 22 exhibited the most significant inhibitory activity among the isolates against nitric oxide (NO) release in lipopolysaccharide (LPS)-activated BV2 cells with an IC₅₀ value of 22.41 μM.

关键词: Aglaia odorata Lour., Diterpenoids, Triterpenoids, Anti-neuroinflammation, Anti-ferroptosis, Neuroprotective activity

Meng Ding, Yue-Han Wang, Chen-Hao Liu, Wang-Xiao Tan, Li-Ming Hu, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang. Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.[J]. Natural Products and Bioprospecting, 2026, 16(1): 10-10.

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