Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

doi:10.1007/s13659-019-00227-y

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (6): 419-424.DOI: 10.1007/s13659-019-00227-y

• ORIGINAL ARTICLES • Previous Articles Next Articles

Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

Jun Wang, Xian-Hua Meng, Tian Chai, Jun-Li Yang, Yan-Ping Shi

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China

Received:2019-10-24 Revised:2019-11-07 Online:2019-12-11 Published:2019-12-24
Contact: Jun-Li Yang, Yan-Ping Shi
Supported by:
This work was financially supported by National Natural Science Foundation of China (Nos. 81673325 and 81711540311), the International Partnership Program of CAS (No. 153631KYSB20160004), Gansu Province Key International S&T Cooperation Project (No. 18YF1WA127), and CAS Pioneer Hundred Talents Program.

Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

Jun Wang, Xian-Hua Meng, Tian Chai, Jun-Li Yang, Yan-Ping Shi

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China

通讯作者: Jun-Li Yang, Yan-Ping Shi
基金资助:
This work was financially supported by National Natural Science Foundation of China (Nos. 81673325 and 81711540311), the International Partnership Program of CAS (No. 153631KYSB20160004), Gansu Province Key International S&T Cooperation Project (No. 18YF1WA127), and CAS Pioneer Hundred Talents Program.

Abstract

Abstract: Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1-3, two aconitinetype diterpenoid alkaloids 4-5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ_1-42 aggregates.

Key words: Aconitum pendulum, Alkaloids, Lignan, Anti-AD activity

摘要： Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1-3, two aconitinetype diterpenoid alkaloids 4-5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ_1-42 aggregates.

关键词: Aconitum pendulum, Alkaloids, Lignan, Anti-AD activity

Jun Wang, Xian-Hua Meng, Tian Chai, Jun-Li Yang, Yan-Ping Shi. Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch[J]. Natural Products and Bioprospecting, 2019, 9(6): 419-424.

Jun Wang, Xian-Hua Meng, Tian Chai, Jun-Li Yang, Yan-Ping Shi. Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch[J]. 应用天然产物, 2019, 9(6): 419-424.

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Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

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