Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

doi:10.1007/s13659-013-0024-9

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (3): 89-92.DOI: 10.1007/s13659-013-0024-9

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Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

Wei-Wei FAN^a,b, Feng-Qing XU^a,b, Fa-Wu DONG^a,b, Xiao-Nian LI^a, Yan LI^a, Yu-Qing LIU^a, Jun ZHOU^a, Jiang-Miao HU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-03-17 Revised:2013-04-02 Online:2018-02-11 Published:2013-06-24
Supported by:
The authors are grateful to Dr. Xiao-Hua Jin of Institute of Botany, Chinese Academy of Sciences, for identification of the plant. This work was financially supported by the National Natural and Science Foundations of China (No. 30800090), "Xi-Bu-Zhi-Guang" project (No. 2009312D11017) from Chinese Academy of Sciences and the Fund of the State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ012).

Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

Wei-Wei FAN^a,b, Feng-Qing XU^a,b, Fa-Wu DONG^a,b, Xiao-Nian LI^a, Yan LI^a, Yu-Qing LIU^a, Jun ZHOU^a, Jiang-Miao HU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Jiang-Miao HU,E-mail:hujiangmiao@mail.kib.ac.cn
基金资助:
The authors are grateful to Dr. Xiao-Hua Jin of Institute of Botany, Chinese Academy of Sciences, for identification of the plant. This work was financially supported by the National Natural and Science Foundations of China (No. 30800090), "Xi-Bu-Zhi-Guang" project (No. 2009312D11017) from Chinese Academy of Sciences and the Fund of the State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ012).

Abstract

Abstract: Dendrowardol C (1)-a novel sesquiterpenoid, with an unprecedented 4/5/6/6 tetracyclic carbon backbone, together with two known cyclopacamphane-type sesquiterpenoids; dendronobilin I (2) and dendrobane A (3) were isolated from the stems of Dendrobium wardianum Warner. The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography. The hypothetical biosynthetic pathway of 1 was postulated. Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

Key words: Dendrobium wardianum Warner, sesquiterpenoid, dendrowardol, X-ray

摘要： Dendrowardol C (1)-a novel sesquiterpenoid, with an unprecedented 4/5/6/6 tetracyclic carbon backbone, together with two known cyclopacamphane-type sesquiterpenoids; dendronobilin I (2) and dendrobane A (3) were isolated from the stems of Dendrobium wardianum Warner. The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography. The hypothetical biosynthetic pathway of 1 was postulated. Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

关键词: Dendrobium wardianum Warner, sesquiterpenoid, dendrowardol, X-ray

Wei-Wei FAN, Feng-Qing XU, Fa-Wu DONG, Xiao-Nian LI, Yan LI, Yu-Qing LIU, Jun ZHOU, Jiang-Miao HU. Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner[J]. Natural Products and Bioprospecting, 2013, 3(3): 89-92.

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Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

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