New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

doi:10.1007/s13659-019-00226-z

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (6): 425-429.DOI: 10.1007/s13659-019-00226-z

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New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

Xiang-Mei Li^1,2, Xian-Jun Jiang^1,2, Guo-Zhu Wei^1,2, Li-Hua Ren^1,2, Li-Xia Wang^1,2, Xue-Lian Cheng^1,3, Fei Wang^1,2

1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China;
3 Department of Pharmacy, The People's Hospital of Fengjie County, Chongqing 404600, People's Republic of China

Received:2019-08-27 Revised:2019-11-05 Online:2019-12-11 Published:2019-12-24
Contact: Fei Wang
Supported by:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

Xiang-Mei Li^1,2, Xian-Jun Jiang^1,2, Guo-Zhu Wei^1,2, Li-Hua Ren^1,2, Li-Xia Wang^1,2, Xue-Lian Cheng^1,3, Fei Wang^1,2

1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China;
3 Department of Pharmacy, The People's Hospital of Fengjie County, Chongqing 404600, People's Republic of China

通讯作者: Fei Wang
基金资助:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

Abstract

Abstract: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3-10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum.

Key words: Tabernaemontana divaricata, Iboga-type indole alkaloid, Single crystal X-ray diffraction

摘要： Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3-10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum.

关键词: Tabernaemontana divaricata, Iboga-type indole alkaloid, Single crystal X-ray diffraction

Xiang-Mei Li, Xian-Jun Jiang, Guo-Zhu Wei, Li-Hua Ren, Li-Xia Wang, Xue-Lian Cheng, Fei Wang. New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata[J]. Natural Products and Bioprospecting, 2019, 9(6): 425-429.

Xiang-Mei Li, Xian-Jun Jiang, Guo-Zhu Wei, Li-Hua Ren, Li-Xia Wang, Xue-Lian Cheng, Fei Wang. New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata[J]. 应用天然产物, 2019, 9(6): 425-429.

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New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

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