Abstract: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8±13.3% at the dose of 30 mg/kg/day.

Key words: Dobinea delavayi, Anacardiaceae, Noreudesmane sesquiterpenoid, Antimalarial activity

摘要： One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8±13.3% at the dose of 30 mg/kg/day.

关键词: Dobinea delavayi, Anacardiaceae, Noreudesmane sesquiterpenoid, Antimalarial activity