New triterpenoids from the kernels of Azadirachta indica

doi:10.1007/s13659-013-0005-z

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (1): 33-37.DOI: 10.1007/s13659-013-0005-z

New triterpenoids from the kernels of Azadirachta indica

Hong-Wei WANG^a,b, Jie-Qing LIU^a, Jin-Xiong CHEN^a,b, Yuan-Feng YANG^a,b, Yu-Xin YAN^a,b, Zhong-Rong LI^a, Ming-Hua QIU^a,b

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-01-11 Revised:2013-02-19 Online:2018-02-11 Published:2013-02-24
Supported by:
The project was financially supported by the Knowledge Innovation Program of the CAS (Grant No. KSCX2-YW-G-038, KSCX2-EW-R-15), Special Foundation for National Major Basic Research (No.SB2007FY400), as well as Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ14). The authors were sincerely grateful to Mangshi Bright Neem Industry Developments Ltd. for providing research samples, and Professor Li Yan for cytotoxicity bioassay.

New triterpenoids from the kernels of Azadirachta indica

Hong-Wei WANG^a,b, Jie-Qing LIU^a, Jin-Xiong CHEN^a,b, Yuan-Feng YANG^a,b, Yu-Xin YAN^a,b, Zhong-Rong LI^a, Ming-Hua QIU^a,b

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ming-Hua QIU,E-mail:mhchiu@mail.kib.ac.cn
基金资助:
The project was financially supported by the Knowledge Innovation Program of the CAS (Grant No. KSCX2-YW-G-038, KSCX2-EW-R-15), Special Foundation for National Major Basic Research (No.SB2007FY400), as well as Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ14). The authors were sincerely grateful to Mangshi Bright Neem Industry Developments Ltd. for providing research samples, and Professor Li Yan for cytotoxicity bioassay.

Abstract

Abstract: Three new limonoids (1-3) and a new intact triterpenoid (4), along with three known constituents (5-7), were isolated from the dried kernels (after extracting azadirachtin) of Azadirachta indica. The structures of the new compounds 1-benzoyl-3-deacetyl-1-detigloyl salannin (1), 7-tigloyl-12-oxo vilasini (2), azadiralactone (3) and azadirahemiacetal (4) were elucidated by means of spectroscopic analysis. The cytotoxities of these isolated constituents were assayed.

Key words: Azadirachta indica, triterpenoid, limonoids

摘要： Three new limonoids (1-3) and a new intact triterpenoid (4), along with three known constituents (5-7), were isolated from the dried kernels (after extracting azadirachtin) of Azadirachta indica. The structures of the new compounds 1-benzoyl-3-deacetyl-1-detigloyl salannin (1), 7-tigloyl-12-oxo vilasini (2), azadiralactone (3) and azadirahemiacetal (4) were elucidated by means of spectroscopic analysis. The cytotoxities of these isolated constituents were assayed.

关键词: Azadirachta indica, triterpenoid, limonoids

Hong-Wei WANG, Jie-Qing LIU, Jin-Xiong CHEN, Yuan-Feng YANG, Yu-Xin YAN, Zhong-Rong LI, Ming-Hua QIU. New triterpenoids from the kernels of Azadirachta indica[J]. Natural Products and Bioprospecting, 2013, 3(1): 33-37.

Hong-Wei WANG, Jie-Qing LIU, Jin-Xiong CHEN, Yuan-Feng YANG, Yu-Xin YAN, Zhong-Rong LI, Ming-Hua QIU. New triterpenoids from the kernels of Azadirachta indica[J]. 应用天然产物, 2013, 3(1): 33-37.

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New triterpenoids from the kernels of Azadirachta indica

New triterpenoids from the kernels of Azadirachta indica

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