Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

doi:10.1007/s13659-019-00228-x

Natural Products and Bioprospecting ›› 2020, Vol. 10 ›› Issue (1): 13-21.DOI: 10.1007/s13659-019-00228-x

• ORIGINAL ARTICLES • Previous Articles Next Articles

Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

Wen-Lin Yuan¹, Xue-Yun Dong^1,4, Zheng-Rui Huang³, Si-Jia Xiao¹, Ji Ye¹, Xin-Hui Tian², Hui-Liang Li¹, Yun-Heng Shen¹, Wei-Dong Zhang^1,2

1 Department of Phytochemistry, School of Pharmacy, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2 Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
3 Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710048, China;
4 School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian 350108, China

Received:2019-10-27 Revised:2019-11-19 Online:2020-02-29 Published:2020-02-24
Contact: Yun-Heng Shen, Wei-Dong Zhang
Supported by:
The work was supported by NSFC (Nos. 81573318, 31870327, 81230090, 81520108030, 1302658), National Major Project of China (No. 2018ZX09731016-005), The Key Research and Development Program of China (Nos. 2017YFC1702002, 2017YFC1700200), Professor of Chang Jiang Scholars Program, Scientific Foundation of Shanghai China (Nos. 17431902800, 16401901300), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300).

Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

Wen-Lin Yuan¹, Xue-Yun Dong^1,4, Zheng-Rui Huang³, Si-Jia Xiao¹, Ji Ye¹, Xin-Hui Tian², Hui-Liang Li¹, Yun-Heng Shen¹, Wei-Dong Zhang^1,2

1 Department of Phytochemistry, School of Pharmacy, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2 Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
3 Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710048, China;
4 School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian 350108, China

通讯作者: Yun-Heng Shen, Wei-Dong Zhang
基金资助:
The work was supported by NSFC (Nos. 81573318, 31870327, 81230090, 81520108030, 1302658), National Major Project of China (No. 2018ZX09731016-005), The Key Research and Development Program of China (Nos. 2017YFC1702002, 2017YFC1700200), Professor of Chang Jiang Scholars Program, Scientific Foundation of Shanghai China (Nos. 17431902800, 16401901300), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (No. 10DZ2251300).

Abstract

Abstract: Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4-6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke's method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC₅₀ value of 3.98±0.32 μM, comparable to that of positive control NS-398 (IC₅₀ 4.14±0.28 μM).

Key words: Ainsliaea latifolia, Triterpenoids, COX-2, Cucurbitane

摘要： Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4-6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke's method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC₅₀ value of 3.98±0.32 μM, comparable to that of positive control NS-398 (IC₅₀ 4.14±0.28 μM).

关键词: Ainsliaea latifolia, Triterpenoids, COX-2, Cucurbitane

Wen-Lin Yuan, Xue-Yun Dong, Zheng-Rui Huang, Si-Jia Xiao, Ji Ye, Xin-Hui Tian, Hui-Liang Li, Yun-Heng Shen, Wei-Dong Zhang. Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities[J]. Natural Products and Bioprospecting, 2020, 10(1): 13-21.

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Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

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