Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

doi:10.1007/s13659-019-0203-4

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (3): 165-173.DOI: 10.1007/s13659-019-0203-4

• ORIGINAL ARTICLES • Next Articles

Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

Hou-Chao Xu^1,2, Kun Hu¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2019-03-19 Revised:2019-04-03 Online:2019-06-05 Published:2019-06-24
Contact: Pema-Tenzin Puno
Supported by:
This project was supported financially by the National Natural Science Foundation of China (Nos. 81874298 and 81673329).

Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

Hou-Chao Xu^1,2, Kun Hu¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Pema-Tenzin Puno
基金资助:
This project was supported financially by the National Natural Science Foundation of China (Nos. 81874298 and 81673329).

Abstract

Abstract: Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A-D (1-4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity.

Key words: Kadsura coccinea, Lanostane triterpenoid, NMR computation, Anti-platelet aggregation, Anticoagulant

摘要： Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A-D (1-4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity.

关键词: Kadsura coccinea, Lanostane triterpenoid, NMR computation, Anti-platelet aggregation, Anticoagulant

Hou-Chao Xu, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno. Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea[J]. Natural Products and Bioprospecting, 2019, 9(3): 165-173.

Hou-Chao Xu, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno. Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea[J]. 应用天然产物, 2019, 9(3): 165-173.

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Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

Four 14(13→12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

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