应用天然产物 ›› 2012, Vol. 2 ›› Issue (3): 92-103.DOI: 10.1007/s13659-012-0015-2
• Review • 下一篇
Hassan KHALIDa, Wail Elsadig ABDALLAa, Haider ABDELGADIRa, Till OPATZb, Thomas EFFERTHc
收稿日期:2012-02-15
修回日期:2012-03-29
出版日期:2012-06-24
发布日期:2018-02-11
通讯作者:
Thomas EFFERTH,E-mail:efferth@uni-mainz.de
Hassan KHALIDa, Wail Elsadig ABDALLAa, Haider ABDELGADIRa, Till OPATZb, Thomas EFFERTHc
Received:2012-02-15
Revised:2012-03-29
Online:2012-06-24
Published:2018-02-11
摘要： Sudanese folk medicine represents a unique blend of indigenous cultures with Islamic, Arabic and African traditions. In addition, Sudan encompasses different terrains and climatic zones, ranging from desert and semi-desert in the north to equatorial with a short rainy season(semi-aridand semi-humid) in the centre to equatorial with a long rainy season(arid-humid and equatorialhumid) in the south. This variation contributes to the immense diversity of vegetation in the region. The flora of Sudan consists of 3137 species of flowering plants belonging to 170 families and 1280 genera. It is estimated that 15% of these plants are endemic to Sudan. The intersection of diverse cultures and the unique geography holds great potential for Sudanese herbal medicine. Medicinal and aromatic plants and their derivatives represent an integral part of life in Sudan. Indigenous remedies are the only form of therapy available to the majority of poor people. It has been estimated that only 11% of the population has access to formal health care. Therefore, research on the desired pharmacological effects and possible unwanted side effects or toxicity is required to improve efficacy and safety of Sudanese herbal medicine. In the future, it would be preferable to promote the use of traditional herbal remedies by conversion of raw plant material into more sophisticated products instead of completely replacing the traditional remedies with synthetic products from industrialized countries. The present review gives an overview of traditional Sudanese medicinal and aromatic herbs and their habitats, traditional uses, and phytochemical constituents.
Hassan KHALID, Wail Elsadig ABDALLA, Haider ABDELGADIR, Till OPATZ, Thomas EFFERTH. Gems from traditional north-African medicine: medicinal and aromatic plants from Sudan[J]. 应用天然产物, 2012, 2(3): 92-103.
Hassan KHALID, Wail Elsadig ABDALLA, Haider ABDELGADIR, Till OPATZ, Thomas EFFERTH. Gems from traditional north-African medicine: medicinal and aromatic plants from Sudan[J]. Natural Products and Bioprospecting, 2012, 2(3): 92-103.
| [1] Akerele, O. Fitoterapia 1988, 59, 355-367. [2] Khalid, H. S. Biological & Phytochemical Studies on Albizzia anthelmintica. Ph.D. Thesis, Department of Pharmacognosy, Faculty Pharmacy, University of Khartoum, August 1991. [3] Alkhalifa Al Mugtadir (908-938), Cited by Hamid MR. "Gisat Al Dawa Ailm wa Tahdyat" (Arabic), MR Hamid, Maktaba Al Academia 121 Shari Al Tahrir Dougi Algeeza, Cairo, Egypt. www.newadvent.org/cathen/10122a.htm. [4] Abu Bakr Al Razi (854-932) Kitab Alhawi (Arabic). Ministry of Education Printing Press, Haiderabad, India. [5] Ibn El Bitar (1248 A.D.). Al Jami Li Mfradat Al Dawiyya wa Al Aghzhiyya (Mufradat Ibn EL Bitar) (Arabic). Four Volumes, Cairo Matba'at Bulaq, 1874. [6] Al Dainori, Ahmed Ibn Daoud. Kitab Alnabat (Arabic). Lieden:B. Loin, 1953. [7] Daoud Al-Antaky (1600 A.D.). Tazkirt Ulil Al Albab wa Aljami'a Lil Ajab Alujab (Popularly known as Tazkirt Daoud Alantaki) (Arabic). Cairo; Matha'at Abd Alraziq publishers. [8] Khalid, S. A. Nat. Prod. Comm. 2009, 4, 1431-1446. [9] El-Hamidi, A. Planta Med. 1970, 18, 279-280. [10] Banthorpe, D. V.; Duprey, R. J.; Hassan, M.; Janes, J. F.; Modawi, B. M. Planta Med. 1976, 29, 10-25. [11] Antoun, M. D.; El Khawad, A. O.; Taha, O. M. Lloydia 1977, 40, 337-339. [12] Antoun, M. D.; Taha, O. M. J. Nat. Prod. 1981, 44, 179-183. [13] El Sheikh, M. O.; El Hassan, G. M.; El Tayeb Abdel Hafeez, A. R.; Abdalla, A. A.; Antoun, M. D. Planta Med. 1982, 45, 16-119. [14] El Ghazali, G. E. B. Medicinal Plants of Sudan Part I. Medicinal Plants of Erkawit, National Council for Research, Khartoum, 1986. [15] El Ghazali, G. E. B.; Bari, E. A.; Bashir, A. K.; Salih, A. M. Medicinal Plants of Sudan Part Ⅱ. Medicinal Plants of Eastern Nuba Mountains. National Council for Research, Khartoum, 1987. [16] El Ghazali, G. E. B.; El Tohami, M. S.; El Egami, A. A. B. Medicinal Plants of the Sudan Part Ⅲ, Medicinal Plants of White Nile Province. National Council for Research, Khartoum, 1994. [17] El Ghazali, G. E. B.; El Tohami, M. S.; El Egami, A. A.; Abdalla, W. E.; Galal, M. Medicinal Plants of the Sudan Part IV. Medicinal Plants of North Kordofan. National Council for Research, Khartoum, 1997. [18] El Ghazali, G. E. B.; Abdalla, W. E.; Khalid, H. E.; Khalafalla, M. M.; Hamad, A. A. Medicinal Plants of the Sudan Part V. Medicinal Plants of Ingassana Area. National Council for Research, Khartoum, 2003. [19] El-Tahir, A.; Satti, G. M.; Khalid, S. A. Phytother. Res. 1999, 13, 474-478. [20] Hussein, G.; Miyashiro, H.; Nakamura, N.; Hattori, M.; Kakiuchi, N.; Shimotohno, K. Phytother. Res. 2000, 14, 510-516. [21] Elegami, A. A.; Almagboul, A. Z.; Omer, M. E.; El Tohami, M. S. Fitoterapia 2001, 72, 810-817. [22] Ali, H.; Konig, G. M.; Khalid, S. A.; Wright, A. D.; Kaminsky, R. J. Ethnopharmacol. 2002, 83, 219-228. [23] Ahmed, El-H. M.; Nour, B. Y.; Mohammed, Y. G.; Khalid, H. S. Environmental Health Insights 2010, 4, 1-6. [24] El Kheir, Y. M.; El Tohami, M. S. J. Trop. Med. Hygiene 1979, 82, 242-247. [25] Ahmed, E. H.; Bashir, A. K.; El Kheir, Y. M. Planta Med. 1984, 50, 74-77. [26] Koko, W. S.; Galal, M.; Khalid, H. S. J. Ethnopharmacol. 2000, 71, 247-252. [27] Koko, W. S.; Abdalla, H. S.; Galal, M.; Khalid, H. S. Fitoterapia 2005, 76, 30-34. [28] Koko, W. S.; Mesaik, M. A.; Yousaf, S.; Galal, M.; Choudhary, M. I. J. Ethnopharmacol. 2008, 118, 26-34. [29] White, F. Nat. Resources Res. 1983, 20, 1-1356. [30] Tuley De Silva. Manual on The Essential Oil Industry, Presentations made by the resource persons at third UNIDO workshop on essential oil and aroma chemical industries held at the Andoulu University, Medicinal and Aromatic Plant and Drug development. Eskisher, Turkey, 1996. [31] Arcury, T. A.; Grzywacz, J. G.; Stoller, E. P.; Bell, R. A.; Altizer, K. P.; Chapman, C.; Quandt, S. A. J. Gerontology 2009, Series B, Psychol. Sci. and Social Sci. 64, 635-643. [32] Bakhiet, A. O.; Adam, S. E. Veterinary Hum. Toxicol. 1995, 37, 255-258. [33] Omer, S. A.; Adam, S. E. Veterinary Hum. Toxicol. 1999, 41, 299-301. [34] Barri, M. E.; Onsa, T. O.; Elawad, A. A.; Elsayed, N. Y.; Wasfi, I. A.; Abdul-Bari, E. M.; Adam, S. E. J. Comparative Pathol. 1983, 93, 559-575. [35] Barakat, S. E.; Wasfi, I. A.; Adam, S. E. Veterinary Pathol. 1983, 20, 611-616. [36] Galal, M.; Adam, S. E. Veterinary Hum. Toxicol. 1988, 30, 447-452. [37] Galal, M.; Bashir, A. K.; Salih, A. M.; Adam, S. E. J. Ethnopharmacol. 1991, 31, 333-337. [38] Galal, M.; Bashir, A. K.; Salih, A. M.; Adam, S. E. Veterinary Hum. Toxicol. 1991, 33, 537-539. [39] Baser, K. H. C.; Abeywickrama, K. Fact-Finding and Preparatory Assistance to Assess the Potential for the Industrial Utilization of Medicinal and Aromatic Plants in Sudan, UNIDO Mission Report, Khartoum, 1995. [40] Vasisht, K.; Kumar, V. Compendium of Medicinal and Aromatic Plants-Volume I-Africa. UNIDO (United Nations Industrial Development Organization), 2006. [41] Farnsworth, N. R.; Akerele, O.; Bingel, A. S.; Soejarta, D. D.; Eno, Z. Bull. World Health Org. 1985, 63, 965-981. [42] Blumenthal, M. (Ed). The ABC Clinical Guide to Herbs. American Botanical Council/Thieme, New York, 2003. [43] Singh, R.; Singh, B.; Singh, S.; Kumar, N.; Kumar, S.; Arora, S. Toxicol. In Vitro 2008, 22, 1965-1970. [44] Singh, R.; Singh, B.; Singh, S.; Kumar, N.; Kumar, S.; Arora, S. J. Food Chem. 2010, 120, 825-830. [45] Eldeen, I. M.; Van Heerden, F. R.; Van Staden, J. J. Ethnopharmacol. 2010, 128, 555-560. [46] Aspinall, G. O.; Hunt, K.; Morrison, I. M. J. Chem. Soc. Perkin 11966, 21, 1945-1949. [47] Mueller-Harvey, I.; Hartley, R. D.;Reed, J. D. J. Sci. Food Agricult. 1987, 39, 1-14. [48] Mangan, J. L. Nutr. Res. Rev. 1988, 1, 209-231. [49] Kinghorn, A. D.; Chai, H. B.; Sung, C. K.; Keller, W. J. Fitoterapia 2011, 82, 71-79. [50] Viljoen, A. M.; Wyk, B. V.; Newton, L. E. Biochem. Systematics Ecol. 2001, 29, 53-67. [51] Mahmoud, A. A.; Ahmed, A. A.; El Bassuony, A. A. Fitoterapia 1999, 70, 575-578. [52] Siddiqui, B. S.; Afshan, F.; Gulzar, T.; Hanif, M. Phytochem. 2004, 65, 2363-2367. [53] Ragasa, C. Y.; Nacpil, Z. D.; Natividad, G. M.; Tada, M.; Coll, J. C.; Rideout, J. A. Phytochem. 1997, 46, 555-558. [54] Beit-Yannai, E.; Ben-Shabat, S.; Goldschmidt, N.; Chapagain, B. P.; Liu, R. H.; Wiesman, Z. Phytochem. Lett. 2011, 4, 43-47. [55] Kim, T. R.; Pastuszyn, A.; Vanderjagt, D. J.; Glew, R. S.; Millson, M.; Glew, R. H. J. Food Comp. Analysis 1997, 10, 73-81. [56] Hamm, S.; Bleton, J.; Connan, J.; Tchapla, A. Phytochemistry 2005, 66, 1499-1514. [57] Schweiggert, U.; Carle, R.; Schieber, A. Analyt. Chim. Acta. 2006, 557, 236-244. [58] Tannin-Spitz, T.; Grossman, S.; Dovrat, S.; Gottlieb, H. E.; Bergman, M. Biochem. Pharmacol. 2007, 73, 56-67. [59] Ngadjui, B. T.; Abegaz, B. M.; Keumedjio, F.; Folefoc, G. N.; Kapche, G. W. F. Phytochemistry 2002, 60, 345-349. [60] Ngadjui, B. T.; Folefoc, G. G.; Keumedjio, F.; Dongo, E.; Sondengam, B. L.; Connolly, J. D. Phytochemistry 1999, 51, 171-174. [61] Block, S.; Baccelli, C.; Tinant, B.; Meervelt, L. V.; Rozenberg, R.; Jiwan, J. L. H.; Llabrès, G.; De Pauw-Gillet, M. C.; QuetinLeclercq, J. Phytochemistry 2004, 65, 1165-1171. [62] Stange, R. R. Jr.; Sims, J. J.; Midland, S. L.; McDonald, R. E. Phytochemistry 1999, 52, 41-43. [63] Shahi, A. K.; Kaul, M. K.; Gupta, R.; Dutt, P.; Chandra, S.; Qazi, G. N. Flavour Fragrance J. 2005, 20,118-121. [64] El-Askary, H. I.; Meselhy, M. R.; Galal, A. M. Molecules 2003, 8, 670-677. [65] Ragasa, C. Y.; Co, A. L.; Rideout, J. A. Nat. Prod. Res. 2005, 19, 231-237. [66] The Ayurvedic Pharmacopoeia of India. Part I, Vol. Ⅱ. Government of India, Ministry of Health and Family Welfare.Namo Narayana. First edition, New Delhi, India, 1999. [67] Bouchet, N.; Levesque, J.; Blond, A.; Bodo, B.; Pousset, J. L. Phytochemistry 1996, 42, 189-190. [68] Mahmoud, E. H. N.; Khalid, S. A. Phytochemistry 1997, 46, 793-794. [69] Fiot, J.; Sanon, S.; Azas, N.; Mahiou, V.; Jansen, O.;Angenot, L.; Balansard, G.; Ollivier, E. Ethnopharmacol. 2006, 106, 173-178. [70] Tseng, T. H.; Hsu, J. D.; Lo, M. H.; Chu, C. Y.; Chou, F. P.; Huang, C. L.; Wang, C. J. Cancer Lett. 1998, 126, 199-207. [71] Hou, D. X.; Tong, X.; Terahara, N.; Luo, D.; Fujii, M. Arch. Biochem. Biophys. 2005, 440, 101-109. [72] Abdelgaleil, S. A. M.; Okamura, H.; Iwagawa, T.; Sato, A.; Miyahara, I.; Doe, M.; Nakatani, M. Tetrahedron 2001, 57, 119-126. [73] Govendachari, T. R.; Krishna Kumari, G. N. Phytochemistry 1998, 47, 1423-1425. [74] Hsouna, A. B.; Trigui, M.; Culioli, G.; Blache, Y.; Jaoua, S. Food Chem. 2011, 125, 193-200. [75] Erdelmeier, C. A.; Regenass, U.; Rali, T.; Sticher, O. Planta Med. 1992, 58, 43-48. [76] Shigemori, H.; Kagata, T.; Ishiyama, H.; Morah, F.; Ohsaki, A.; Kobayashi, J. Chem. Pharm. Bull. 2003, 51, 58-61. [77] Grayer, R. J.; Kite, G. C.; Veitch, N. C.; Eckert, M. R.; Marin, P. D.; Senanayake, P.; Paton, A. J. Biochem. Syst. Ecol. 2002, 30, 327-342. [78] Baliga, M. S.; Baliga, B. R. V.; Shaun Mathew Kandathil, S. M.; Bhat, H. P.; Vayalil, P. K. Food Res. Intern. 2011, 44, 1812-1822. [79] Ferraz, A. C.; Angelucci, M. E.; Da Costa, M. L.; Batista, I. R.; De Oliveira, B. H.; Da Cunha, C. Pharmacol. Biochem. Behav. 1999, 63, 367-375. [80] Holfelder, M. G. A. H.; Steck, M.; Komor, E.; Seifert, K. Phytochemistry 1998, 47, 1461-1463. [81] Malik, S.; Ahmad, S. S.; Haider, S. I.; Muzaffar, A. Tetrahedron Lett. 1987, 28, 163-164. [82] Ohtani, K.; Kasai, R.; Yamasaki, K.; Tanaka, O.; Kamel, M. S.; Assaf, M. H.; El-Shanawani, M. A.; Ali, A. A. Phytochemistry 1992, 31, 2469-2471. [83] Oshio, H.; Imai, S.; Fujioka, T.; Sugawara, M.; Miyamoto, M.; Tsukui, M. Chem. Pharm. Bull. 1974, 22, 823-831. [84] Oshio, H.; Tsukui, M.; Matsuoka, T. Chem. Pharm. Bull. 1978, 26, 2096-2097. [85] Wu, Q. P.; Wang, Z. J.; Fu, M. H.; Tang, L. Y.; He, Y.; Fang, J.; Gong, Q. F. Zhong Yao Cai 2007, 30, 1250-1252.[Article in Chinese] [86] Hasan, A. F.; Furumoto, T.; Begum, S.; Fukui, H. Phytochemistry 2001, 58, 1225-1228. [87] Furumoto, T.; Iwata, M.; Feroj Hasan, A. F.; Fukui, H. Phytochemistry 2003, 64, 863-866. [88] Eltayeb, E. A.; Al-Ansari, A. S.; Roddick, J. G. Phytochemistry 1997, 46, 489-494. [89] Kamel, M. S.; Ohtani, K.; Hasanain, H. A.; Mohamed, M. H.; Kasai, R.; Yamasaki, K. Phytochemistry 2000, 53, 937-940. [90] Hassan, H. A.; Hamed, A. I.; El-Emary, N. A.; Springue, I. V.; Mitome, H.; Miyaoka, H. Phytochemistry 2001, 57, 507-511. [91] Sudjaroen, Y.; Haubner, R.; Würtele, G.; Hull, W. E.; Erben, G.; Spiegelhalder, B.; Changbumrung, S.; Bartsch, H.; Owen, R. W. Food Chem. Toxicol. 2005, 43, 1673-1682. [92] Han, Y.; Nishibe, S.; Noguchi, Y.; Jin, Z. Phytochemistry 2001, 58, 577-580. [93] Evidente, A.; Fernandez-Aparicio, M.; Andolfi, A.; Rubiales, D.; Motta, A. Phytochemistry 2007, 68, 2487-2492. |
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