Limonoid and Steroidal Saponin from Azadirachta indica

doi:10.1007/s13659-014-0042-2

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (6): 335-340.DOI: 10.1007/s13659-014-0042-2

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Limonoid and Steroidal Saponin from Azadirachta indica

Lu Liu^1,2, Yun-Li Zhao¹, Gui-Guang Cheng³, Ying-Ying Chen^1,2, Xu-Jie Qin^1,2, Chang-Wei Song^1,2, Xing-Wei Yang^1,2, Ya-Ping Liu¹, Xiao-Dong Luo¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, People's Republic of China

Received:2014-08-07 Revised:2014-10-12 Online:2018-02-11 Published:2014-12-24
Supported by:
The authors are grateful to the Natural Science Foundation of China(81225024), the National Science and Technology Support Program of China(2013BAI11B02), for partial financial support, and to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, for the spectral measurement.

Limonoid and Steroidal Saponin from Azadirachta indica

Lu Liu^1,2, Yun-Li Zhao¹, Gui-Guang Cheng³, Ying-Ying Chen^1,2, Xu-Jie Qin^1,2, Chang-Wei Song^1,2, Xing-Wei Yang^1,2, Ya-Ping Liu¹, Xiao-Dong Luo¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, People's Republic of China

通讯作者: Ya-Ping Liu,e-mail:liuyaping@mail.kib.ac.cn;Xiao-Dong Luo,e-mail:liuyaping@mail.kib.ac.cn
基金资助:
The authors are grateful to the Natural Science Foundation of China(81225024), the National Science and Technology Support Program of China(2013BAI11B02), for partial financial support, and to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, for the spectral measurement.

Abstract

Abstract: A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide(1), and a new C21 steroidal saponin, 2α, 4α-dihydroxy-pregn-5-en-16-one-3α-O-D-glucopyranoside(2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their antibacterial activities against six bacterial strains.

Key words: Azadirachta indica, Limonoid, Steroidal saponin, Antibacterial activities

摘要： A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide(1), and a new C21 steroidal saponin, 2α, 4α-dihydroxy-pregn-5-en-16-one-3α-O-D-glucopyranoside(2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their antibacterial activities against six bacterial strains.

关键词: Azadirachta indica, Limonoid, Steroidal saponin, Antibacterial activities

Lu Liu, Yun-Li Zhao, Gui-Guang Cheng, Ying-Ying Chen, Xu-Jie Qin, Chang-Wei Song, Xing-Wei Yang, Ya-Ping Liu, Xiao-Dong Luo. Limonoid and Steroidal Saponin from Azadirachta indica[J]. Natural Products and Bioprospecting, 2014, 4(6): 335-340.

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Limonoid and Steroidal Saponin from Azadirachta indica

Limonoid and Steroidal Saponin from Azadirachta indica

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