Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

doi:10.1007/s13659-011-0030-8

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (1): 29-34.DOI: 10.1007/s13659-011-0030-8

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Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Wen-Xing LIU^a,b, Gui-Hua TANG^a,b, Hong-Ping HE^a, Yu ZHANG^a, Shun-Lin LI^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2011-11-09 Revised:2011-02-13 Online:2018-02-11 Published:2012-02-24
Supported by:
This work was supported by grants from the Ministry of Science and Technology(2009CB522300 and 2009CB940900).

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Wen-Xing LIU^a,b, Gui-Hua TANG^a,b, Hong-Ping HE^a, Yu ZHANG^a, Shun-Lin LI^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Shun-Lin LI,E-mail:haoxj@mail.kib.ac.cn;Xiao-Jiang HAO,E-mail:lisl@mail.kib.ac.cn
基金资助:
This work was supported by grants from the Ministry of Science and Technology(2009CB522300 and 2009CB940900).

Abstract

Abstract: Four new limonoids, dysohainanins A-D(1-4), and two new triterpenoids, dysohainanins E and F(5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4, 16, 18-trihydroxy-8(14)-pomaren-15-one(13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC₅₀ values of 24.3, 28.1, 30.7, and 22.5 μM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.

Key words: Dysoxylum hainanense, Meliaceae, limonoids, triterpenoids, cytotoxicity

摘要： Four new limonoids, dysohainanins A-D(1-4), and two new triterpenoids, dysohainanins E and F(5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4, 16, 18-trihydroxy-8(14)-pomaren-15-one(13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC₅₀ values of 24.3, 28.1, 30.7, and 22.5 μM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.

关键词: Dysoxylum hainanense, Meliaceae, limonoids, triterpenoids, cytotoxicity

Wen-Xing LIU, Gui-Hua TANG, Hong-Ping HE, Yu ZHANG, Shun-Lin LI, Xiao-Jiang HAO. Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense[J]. Natural Products and Bioprospecting, 2012, 2(1): 29-34.

Wen-Xing LIU, Gui-Hua TANG, Hong-Ping HE, Yu ZHANG, Shun-Lin LI, Xiao-Jiang HAO. Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense[J]. 应用天然产物, 2012, 2(1): 29-34.

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Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

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