Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

doi:10.1007/s13659-013-0074-z

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (6): 267-270.DOI: 10.1007/s13659-013-0074-z

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Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

Cheng-Shi JIANG^a, Yan LI^a, Zhen-Zhong WANG^b, Xiao-Yin HUANG^a, Wei XIAO^b, Yue-Wei GUO^a

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
b Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China

Received:2013-09-23 Revised:2013-10-22 Online:2018-02-11 Published:2013-12-24
Supported by:
This research work was financially supported by the National Marine ‘863’ Projects (No. 2013AA092902), the Natural Science Foundation of China (Nos. 21021063, 81273430, and 2107224), and was partially funded by the EU 7th Framework Programme-IRSES Project (No. 246987).

Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

Cheng-Shi JIANG^a, Yan LI^a, Zhen-Zhong WANG^b, Xiao-Yin HUANG^a, Wei XIAO^b, Yue-Wei GUO^a

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
b Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China

通讯作者: Wei XIAO,E-mail:wzhzh-nj@163.net;Yue-Wei GUO,E-mail:ywguo@mail.shcnc.ac.cn
基金资助:
This research work was financially supported by the National Marine ‘863’ Projects (No. 2013AA092902), the Natural Science Foundation of China (Nos. 21021063, 81273430, and 2107224), and was partially funded by the EU 7th Framework Programme-IRSES Project (No. 246987).

Abstract

Abstract: A new trijugin-type limonoid, cipatrijugin G (1), together with the related known cipatrijugin A (2), were isolated from the aerial parts of Cipadessa cinerascens. The structure of the new compound was determined by extensive analysis of its spectroscopic data and by comparison of its NMR data with those reported in the literature. Compound 1 showed cytotoxicity against tumor cell line A549 with an IC₅₀ value of 9.78 μM. This is the first report of a trijugin-type limonoid bearing a γ-hydroxybutenolide unit, in comparison to the common furan unit as ring E.

Key words: Cipadessa cinerascens, trijugin-type, limonoid

摘要： A new trijugin-type limonoid, cipatrijugin G (1), together with the related known cipatrijugin A (2), were isolated from the aerial parts of Cipadessa cinerascens. The structure of the new compound was determined by extensive analysis of its spectroscopic data and by comparison of its NMR data with those reported in the literature. Compound 1 showed cytotoxicity against tumor cell line A549 with an IC₅₀ value of 9.78 μM. This is the first report of a trijugin-type limonoid bearing a γ-hydroxybutenolide unit, in comparison to the common furan unit as ring E.

关键词: Cipadessa cinerascens, trijugin-type, limonoid

Cheng-Shi JIANG, Yan LI, Zhen-Zhong WANG, Xiao-Yin HUANG, Wei XIAO, Yue-Wei GUO. Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens[J]. Natural Products and Bioprospecting, 2013, 3(6): 267-270.

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Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

Cipatrijugin G,a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

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