Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

doi:10.1007/s13659-013-0017-8

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (2): 56-60.DOI: 10.1007/s13659-013-0017-8

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Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Shan-Zhai SHANG^a,c, Ying-Shan HAN^b, Yi-Ming SHI^a,c, Xue DU^a, Cheng-Qin LIANG^a,c, Mark A. WAINBERG^b, Zhong-Hua GAO^a,c, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b McGill University AIDS Centre, Lady Davis for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada;
c University of Chinese Academy of Sciences, Beijing 100049, China

Received:2013-02-26 Revised:2013-03-27 Online:2018-02-11 Published:2013-04-24
Supported by:
This project was supported financially by the NSFC (No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), the Natural Science Foundation of Yunnan Province (No. 2012FB178), and a part of this work was financially supported by the Canadian Institutes for Health Research.

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Shan-Zhai SHANG^a,c, Ying-Shan HAN^b, Yi-Ming SHI^a,c, Xue DU^a, Cheng-Qin LIANG^a,c, Mark A. WAINBERG^b, Zhong-Hua GAO^a,c, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b McGill University AIDS Centre, Lady Davis for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada;
c University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Wei-Lie XIAO,E-mail:xwl@mail.kib.ac.cn;Han-Dong SUN,E-mail:hdsun@mail.kib.ac.cn
基金资助:
This project was supported financially by the NSFC (No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), the Natural Science Foundation of Yunnan Province (No. 2012FB178), and a part of this work was financially supported by the Canadian Institutes for Health Research.

Abstract

Abstract: Four new tetrahydrofuran lignans, schpropinrins A-D (1-4), together with five known ones, were isolated from the leaves and stems of Schisandra propinqua var. sinensis. Their structures, including absolute configurations, were characterized by means of spectroscopic analysis and ECD calculation. Compounds 1-4 featured a ketal or hemiketal substructure at C-7 and all of the isolates were tested for their anti-HIV integrase activity.

Key words: Schisandra propinqua var. sinensi, schpropinrins, lignan, anti-human immunodeficiency virus integrase activity

摘要： Four new tetrahydrofuran lignans, schpropinrins A-D (1-4), together with five known ones, were isolated from the leaves and stems of Schisandra propinqua var. sinensis. Their structures, including absolute configurations, were characterized by means of spectroscopic analysis and ECD calculation. Compounds 1-4 featured a ketal or hemiketal substructure at C-7 and all of the isolates were tested for their anti-HIV integrase activity.

关键词: Schisandra propinqua var. sinensi, schpropinrins, lignan, anti-human immunodeficiency virus integrase activity

Shan-Zhai SHANG, Ying-Shan HAN, Yi-Ming SHI, Xue DU, Cheng-Qin LIANG, Mark A. WAINBERG, Zhong-Hua GAO, Wei-Lie XIAO, Han-Dong SUN. Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis[J]. Natural Products and Bioprospecting, 2013, 3(2): 56-60.

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Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

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