Two New Compounds from Schisandra propinqua var. propinqua

doi:10.1007/s13659-017-0129-7

Natural Products and Bioprospecting ›› 2017, Vol. 7 ›› Issue (3): 257-262.DOI: 10.1007/s13659-017-0129-7

Two New Compounds from Schisandra propinqua var. propinqua

Miao Liu^1,2, Zheng-Xi Hu³, Yuan-Qing Luo^1,2, Min Zhou^1,2, Wei-Guang Wang¹, Xiao-Nian Li¹, Xue Du¹, Jian-Xin Pu¹, Han-Dong Sun¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China

Received:2017-03-21 Revised:2017-04-18 Online:2018-02-06 Published:2017-06-24
Supported by:
This project was supported financially by the National Natural Science Foundation of China (81373290 and 21322204).

Two New Compounds from Schisandra propinqua var. propinqua

Miao Liu^1,2, Zheng-Xi Hu³, Yuan-Qing Luo^1,2, Min Zhou^1,2, Wei-Guang Wang¹, Xiao-Nian Li¹, Xue Du¹, Jian-Xin Pu¹, Han-Dong Sun¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China

通讯作者: Jian-Xin Pu,e-mail:pujianxin@mail.kib.ac.cn
基金资助:
This project was supported financially by the National Natural Science Foundation of China (81373290 and 21322204).

Abstract

Abstract: Schisanpropinoic acid (1), a new bergamotane sesquiterpenoid, and schisanpropinin (2), a new tetrahydrofuran lignan with a rare epoxyethane unit, were identified from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were determined based on comprehensive spectroscopic and mass spectrometric analysis. The absolute configuration of 1 was determined by X-ray analysis. Compounds 1 and 2 were tested for their cytotoxic activity against five human tumor cell lines.

Key words: Schisandra propinqua var. propinqua, Bergamotane-type sesquiterpenoid, Lignan, Absolute configuration, Cytotoxicity

摘要： Schisanpropinoic acid (1), a new bergamotane sesquiterpenoid, and schisanpropinin (2), a new tetrahydrofuran lignan with a rare epoxyethane unit, were identified from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were determined based on comprehensive spectroscopic and mass spectrometric analysis. The absolute configuration of 1 was determined by X-ray analysis. Compounds 1 and 2 were tested for their cytotoxic activity against five human tumor cell lines.

关键词: Schisandra propinqua var. propinqua, Bergamotane-type sesquiterpenoid, Lignan, Absolute configuration, Cytotoxicity

Miao Liu, Zheng-Xi Hu, Yuan-Qing Luo, Min Zhou, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Jian-Xin Pu, Han-Dong Sun. Two New Compounds from Schisandra propinqua var. propinqua[J]. Natural Products and Bioprospecting, 2017, 7(3): 257-262.

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Two New Compounds from Schisandra propinqua var. propinqua

Two New Compounds from Schisandra propinqua var. propinqua

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