Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

doi:10.1007/s13659-020-00262-0

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (1): 51-62.DOI: 10.1007/s13659-020-00262-0

• ORIGINAL ARTICLES • Previous Articles Next Articles

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

Hong-Jie Zhu², Te Xu¹, Yong-Ming Yan¹, Zheng-Chao Tu^3,4, Yong-Xian Cheng¹

1 School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China;
4 Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, People's Republic of China

Received:2020-07-03 Revised:2020-08-23 Online:2021-03-11 Published:2021-02-24
Contact: Yong-Xian Cheng
Supported by:
This study was supported by the National Science Fund for Distinguished Young Scholars (81525026) and Shenzhen Government’s Plan of Science and Technology (JCYJ20170412110504956).

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

Hong-Jie Zhu², Te Xu¹, Yong-Ming Yan¹, Zheng-Chao Tu^3,4, Yong-Xian Cheng¹

1 School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China;
4 Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, People's Republic of China

通讯作者: Yong-Xian Cheng
基金资助:
This study was supported by the National Science Fund for Distinguished Young Scholars (81525026) and Shenzhen Government’s Plan of Science and Technology (JCYJ20170412110504956).

Abstract

Abstract: Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

Key words: Polyphaga plancyi, Insect medicine, Lignans, Renal protection, Anticoagulant activity

摘要： Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

关键词: Polyphaga plancyi, Insect medicine, Lignans, Renal protection, Anticoagulant activity

Hong-Jie Zhu, Te Xu, Yong-Ming Yan, Zheng-Chao Tu, Yong-Xian Cheng. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities[J]. Natural Products and Bioprospecting, 2021, 11(1): 51-62.

Hong-Jie Zhu, Te Xu, Yong-Ming Yan, Zheng-Chao Tu, Yong-Xian Cheng. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities[J]. 应用天然产物, 2021, 11(1): 51-62.

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Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

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