The chemical structures and biological activities of indole diterpenoids

doi:10.1007/s13659-022-00368-7

Abstract

Abstract: Indole diterpenoids (IDTs) are an essential class of structurally diverse fungal secondary metabolites, that generally appear to be restricted to a limited number of fungi, such as Penicillium, Aspergillus, Claviceps, and Epichloe species, etc. These compounds share a typical core structure consisting of a cyclic diterpene skeleton of geranylgeranyl diphosphate (GGPP) and an indole ring moiety derived from indole-3-glycerol phosphate (IGP). 3-geranylgeranylindole (3-GGI) is the common precursor of all IDTs. On this basis, it is modified by cyclization, oxidation, and prenylation to generate a large class of compounds with complex structures. These compounds exhibit antibacterial, anti-insect, and ion channel inhibitory activities. We summarized 204 compounds of IDTs discovered from various fungi over the past 50 years, these compounds were reclassified, and their biological activities were summarized. This review will help to understand the structural diversity of IDTs and provide help for their physiological activities.

Key words: Indole diterpenoids, Structural classification, Physiological activity, Fungus

摘要： Indole diterpenoids (IDTs) are an essential class of structurally diverse fungal secondary metabolites, that generally appear to be restricted to a limited number of fungi, such as Penicillium, Aspergillus, Claviceps, and Epichloe species, etc. These compounds share a typical core structure consisting of a cyclic diterpene skeleton of geranylgeranyl diphosphate (GGPP) and an indole ring moiety derived from indole-3-glycerol phosphate (IGP). 3-geranylgeranylindole (3-GGI) is the common precursor of all IDTs. On this basis, it is modified by cyclization, oxidation, and prenylation to generate a large class of compounds with complex structures. These compounds exhibit antibacterial, anti-insect, and ion channel inhibitory activities. We summarized 204 compounds of IDTs discovered from various fungi over the past 50 years, these compounds were reclassified, and their biological activities were summarized. This review will help to understand the structural diversity of IDTs and provide help for their physiological activities.

关键词: Indole diterpenoids, Structural classification, Physiological activity, Fungus

Jingwen Niu, Jianzhao Qi, Pengchao Wang, Chengwei Liu, and Jin, ming Gao, Abstract. The chemical structures and biological activities of indole diterpenoids[J]. Natural Products and Bioprospecting, 2023, 13(1): 3-3.

Jingwen Niu, Jianzhao Qi, Pengchao Wang, Chengwei Liu, and Jin, ming Gao, Abstract. The chemical structures and biological activities of indole diterpenoids[J]. 应用天然产物, 2023, 13(1): 3-3.

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