Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

doi:10.1007/s13659-020-00287-5

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (1): 105-110.DOI: 10.1007/s13659-020-00287-5

• ORIGINAL ARTICLES • Previous Articles Next Articles

Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou

Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

Received:2020-10-26 Revised:2020-11-12 Online:2021-03-11 Published:2021-02-24
Contact: Hong-Xiang Lou
Supported by:
The authors gratefully acknowledge the National Natural Science Foundation of China (Nos. 81874293 and 81630093) for financial support and Major Basic Research Program of Shandong Province (ZR2019ZD26).

Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou

Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

通讯作者: Hong-Xiang Lou
基金资助:
The authors gratefully acknowledge the National Natural Science Foundation of China (Nos. 81874293 and 81630093) for financial support and Major Basic Research Program of Shandong Province (ZR2019ZD26).

Abstract

Abstract: Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3-12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC₅₀ values of 49.85, 22.14 and 46.02 μM respectively.

Key words: Endophytic fungus, Quinazoline, Anti-inflammatory activity

摘要： Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3-12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC₅₀ values of 49.85, 22.14 and 46.02 μM respectively.

关键词: Endophytic fungus, Quinazoline, Anti-inflammatory activity

Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou. Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity[J]. Natural Products and Bioprospecting, 2021, 11(1): 105-110.

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Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

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