Lactam Triterpenoids from the Bark of Toona sinensis

doi:10.1007/s13659-016-0108-4

Natural Products and Bioprospecting ›› 2016, Vol. 6 ›› Issue (5): 239-245.DOI: 10.1007/s13659-016-0108-4

• Original article • Previous Articles Next Articles

Lactam Triterpenoids from the Bark of Toona sinensis

Qian-Qian Meng^1,2, Xing-Rong Peng^1,3, Shuang-Yang Lu^1,2, Luo-Sheng Wan^1,3, Xia Wang^1,2, Jin-Run Dong^1,2, Rui Chu^1,2, Lin Zhou^1,3, Xiao-Nian Li^1,3, Ming-Hua Qiu^1,2,3

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan University of Traditional Chinese Medicine, Kunming 650500, People's Republic of China

Received:2016-07-29 Revised:2016-09-22 Online:2018-02-08 Published:2016-10-24
Supported by:
This project was financially supported by Major Program of the National Knowledge Innovation of CAS (No.KSCX2-YW-G-038);and the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2015-ZZ09);Authors also were particularly grateful to Research Group of Prof.Yan Li for bioassay tests

Lactam Triterpenoids from the Bark of Toona sinensis

Qian-Qian Meng^1,2, Xing-Rong Peng^1,3, Shuang-Yang Lu^1,2, Luo-Sheng Wan^1,3, Xia Wang^1,2, Jin-Run Dong^1,2, Rui Chu^1,2, Lin Zhou^1,3, Xiao-Nian Li^1,3, Ming-Hua Qiu^1,2,3

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan University of Traditional Chinese Medicine, Kunming 650500, People's Republic of China

通讯作者: Ming-Hua Qiu,e-mail:mhchiu@mail.kib.ac.cn
基金资助:
This project was financially supported by Major Program of the National Knowledge Innovation of CAS (No.KSCX2-YW-G-038);and the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2015-ZZ09);Authors also were particularly grateful to Research Group of Prof.Yan Li for bioassay tests

Abstract

Abstract: Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.

Key words: Toona sinensis, Limonoids, Lactam triterpenoids, Cytotoxicity

摘要： Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.

关键词: Toona sinensis, Limonoids, Lactam triterpenoids, Cytotoxicity

Qian-Qian Meng, Xing-Rong Peng, Shuang-Yang Lu, Luo-Sheng Wan, Xia Wang, Jin-Run Dong, Rui Chu, Lin Zhou, Xiao-Nian Li, Ming-Hua Qiu. Lactam Triterpenoids from the Bark of Toona sinensis[J]. Natural Products and Bioprospecting, 2016, 6(5): 239-245.

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Lactam Triterpenoids from the Bark of Toona sinensis

Lactam Triterpenoids from the Bark of Toona sinensis

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