Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

doi:10.1007/s13659-015-0085-z

Natural Products and Bioprospecting ›› 2016, Vol. 6 ›› Issue (1): 49-55.DOI: 10.1007/s13659-015-0085-z

• Original article • Previous Articles Next Articles

Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Kai Liu¹, Ya-Bin Yang², Jin-Lian Chen³, Cui-Ping Miao¹, Qiang Wang¹, Hao Zhou², You-Wei Chen¹, Yi-Qing Li¹, Zhong-Tao Ding², Li-Xing Zhao¹

1. Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming 650091, People's Republic of China;
2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
3. School of Energy and Environment Science, Yunnan Normal University, Kunming 650092, People's Republic of China

Received:2015-10-28 Revised:2015-12-20 Online:2018-02-08 Published:2016-02-24
Supported by:
This work was supported partly by grants from the National Natural Science Foundation of China (Nos.81360480,21262041 and 81460536)

Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Kai Liu¹, Ya-Bin Yang², Jin-Lian Chen³, Cui-Ping Miao¹, Qiang Wang¹, Hao Zhou², You-Wei Chen¹, Yi-Qing Li¹, Zhong-Tao Ding², Li-Xing Zhao¹

1. Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming 650091, People's Republic of China;
2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China;
3. School of Energy and Environment Science, Yunnan Normal University, Kunming 650092, People's Republic of China

通讯作者: Li-Xing Zhao,e-mail:zlx70@163.com;Zhong-Tao Ding,e-mail:ztding@ynu.edu.cn
基金资助:
This work was supported partly by grants from the National Natural Science Foundation of China (Nos.81360480,21262041 and 81460536)

Abstract

Abstract: Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.

Key words: Trichoderma koningiopsis, Polyketide, Antifungal activity, Bioactivity assay, Koninginin

摘要： Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.

关键词: Trichoderma koningiopsis, Polyketide, Antifungal activity, Bioactivity assay, Koninginin

Kai Liu, Ya-Bin Yang, Jin-Lian Chen, Cui-Ping Miao, Qiang Wang, Hao Zhou, You-Wei Chen, Yi-Qing Li, Zhong-Tao Ding, Li-Xing Zhao. Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng[J]. Natural Products and Bioprospecting, 2016, 6(1): 49-55.

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Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

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