Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (4): 170-173.DOI: 10.1007/s13659-012-0057-5

• Regular Article • Previous Articles    

Five new polyketides from the basidiomycete Craterellus odoratus

Hua GUOa,b,c, Tao FENGa, Zheng-Hui LIa, Ji-Kai LIUa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b School of Chemistry and Life Science, Anshan Normal College, Anshan 114005, China;
    c Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2012-07-09 Revised:2012-07-30 Online:2018-02-11 Published:2012-08-24
  • Supported by:
    This work was financially supported by National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Science Foundation of China(30830113, U1132607).

Five new polyketides from the basidiomycete Craterellus odoratus

Hua GUOa,b,c, Tao FENGa, Zheng-Hui LIa, Ji-Kai LIUa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b School of Chemistry and Life Science, Anshan Normal College, Anshan 114005, China;
    c Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • 通讯作者: Ji-Kai LIU,E-mail:jkliu@mail.kib.ac.cn
  • 基金资助:
    This work was financially supported by National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Science Foundation of China(30830113, U1132607).

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Abstract: Five new polyketides, craterellones A-E(1-5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds(6-10). Structures of 1-5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase(11β-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values of 0.50, 0.69, 0.64, 1.10, 0.54 μM, respectively.

Key words: Craterellus odoratus, craterellones, polyketides

摘要： Five new polyketides, craterellones A-E(1-5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds(6-10). Structures of 1-5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase(11β-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values of 0.50, 0.69, 0.64, 1.10, 0.54 μM, respectively.

关键词: Craterellus odoratus, craterellones, polyketides

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