Four new indole alkaloids from Plantago asiatica

doi:10.1007/s13659-012-0082-4

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (6): 249-254.DOI: 10.1007/s13659-012-0082-4

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Four new indole alkaloids from Plantago asiatica

Zhong-Hua GAO^a,b, Ling-Mei KONG^a, Xi-Sheng ZOU^a, Yi-Ming SHI^a,b, Shan-Zhai SHANG^a, Huai-Rong LUO^a, Cheng-Qin LIANG^a, Xiao-Nian LI^a, Yan LI^a, Xue DU^a, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-10-17 Revised:2012-12-12 Online:2018-02-11 Published:2012-12-24
Supported by:
This project was supported financially by the grants from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24), the NSFC(No. 20802082 and 30830115), the Major State Basic Research Development Program of China(No. 2009CB522303 and 2009CB940900), and the project of recruited top talent of sciences and technology of Yunnan Province(2006PY01-47).

Four new indole alkaloids from Plantago asiatica

Zhong-Hua GAO^a,b, Ling-Mei KONG^a, Xi-Sheng ZOU^a, Yi-Ming SHI^a,b, Shan-Zhai SHANG^a, Huai-Rong LUO^a, Cheng-Qin LIANG^a, Xiao-Nian LI^a, Yan LI^a, Xue DU^a, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Wei-Lie XIAO,E-mail:xwl@mail.kib.ac.cn;Han-Dong SUN,E-mail:hdsun@mail.kib.ac.cn
基金资助:
This project was supported financially by the grants from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24), the NSFC(No. 20802082 and 30830115), the Major State Basic Research Development Program of China(No. 2009CB522303 and 2009CB940900), and the project of recruited top talent of sciences and technology of Yunnan Province(2006PY01-47).

Abstract

Abstract: Four new indole alkaloids, plasiaticines A-D(1-4), together with two known ones, were isolated from the seeds of Plantago asiatica. The structures of the new compounds were elucidated on the basis of comprehensive analysis of spectroscopic data. All compounds were tested for their cytotoxic activity, and all compounds except 4 were tested for their acetylcholinesterase(AChE) inhibitory activities.

Key words: Plantago asiatica, indole alkaloid, AChE inhibitory activity, cytotoxic activity

摘要： Four new indole alkaloids, plasiaticines A-D(1-4), together with two known ones, were isolated from the seeds of Plantago asiatica. The structures of the new compounds were elucidated on the basis of comprehensive analysis of spectroscopic data. All compounds were tested for their cytotoxic activity, and all compounds except 4 were tested for their acetylcholinesterase(AChE) inhibitory activities.

关键词: Plantago asiatica, indole alkaloid, AChE inhibitory activity, cytotoxic activity

Zhong-Hua GAO, Ling-Mei KONG, Xi-Sheng ZOU, Yi-Ming SHI, Shan-Zhai SHANG, Huai-Rong LUO, Cheng-Qin LIANG, Xiao-Nian LI, Yan LI, Xue DU, Wei-Lie XIAO, Han-Dong SUN. Four new indole alkaloids from Plantago asiatica[J]. Natural Products and Bioprospecting, 2012, 2(6): 249-254.

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Four new indole alkaloids from Plantago asiatica

Four new indole alkaloids from Plantago asiatica

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