Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

doi:10.1007/s13659-012-0026-z

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (3): 133-137.DOI: 10.1007/s13659-012-0026-z

• Regular Article • Previous Articles

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Chuan-Fu DONG^a,b, Lei LIU^a,b, Huai-Rong LUO^a, Xiao-Nian LI^a, Zheng-Ye GUAN^a,b, Yi-Fen WANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-03-25 Revised:2012-05-16 Online:2018-02-11 Published:2012-06-24
Supported by:
This work was supported by the National Natural Science Foundation(20872148). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data.

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Chuan-Fu DONG^a,b, Lei LIU^a,b, Huai-Rong LUO^a, Xiao-Nian LI^a, Zheng-Ye GUAN^a,b, Yi-Fen WANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Yi-Fen WANG,E-mail:wangyifen@mail.kib.ac.cn
基金资助:
This work was supported by the National Natural Science Foundation(20872148). The authors are grateful to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences for measuring NMR, MS, and IR data.

Abstract

Abstract: Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds(1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C(1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether(4). As a result, isodunnianol(7) exhibited anti-AChE activity with an IC₅₀ value of 13.0 μM.

Key words: Illicium simonsii, sesquilignans, sesquiterpenoid, anti-AChE activity

摘要： Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds(1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C(1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether(4). As a result, isodunnianol(7) exhibited anti-AChE activity with an IC₅₀ value of 13.0 μM.

关键词: Illicium simonsii, sesquilignans, sesquiterpenoid, anti-AChE activity

Chuan-Fu DONG, Lei LIU, Huai-Rong LUO, Xiao-Nian LI, Zheng-Ye GUAN, Yi-Fen WANG. Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity[J]. Natural Products and Bioprospecting, 2012, 2(3): 133-137.

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Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

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