Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

doi:10.1007/s13659-017-0138-6

Natural Products and Bioprospecting ›› 2017, Vol. 7 ›› Issue (4): 315-321.DOI: 10.1007/s13659-017-0138-6

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Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

Xu-Jie Qin^1,2, Tong Shu^1,2, Qian Yu^1,2, Huan Yan^1,2, Wei Ni^1,2, Lin-Kun An^1,2, Pan-Pan Li^1,2

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Yunnan Key Laboratory of Medicinal Chemistry, Kunming 650201, People's Republic of China

Received:2017-05-02 Revised:2017-06-07 Online:2018-02-07 Published:2017-08-24
Supported by:
This work was financially supported by National Natural Science Foundation of China (Nos. 31600283 and 31570363) and fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2017-ZZ04) from Kunming Institute of Botany, Chinese Academy of Sciences.

Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

Xu-Jie Qin^1,2, Tong Shu^1,2, Qian Yu^1,2, Huan Yan^1,2, Wei Ni^1,2, Lin-Kun An^1,2, Pan-Pan Li^1,2

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Yunnan Key Laboratory of Medicinal Chemistry, Kunming 650201, People's Republic of China

通讯作者: Hai-Yang Liu,e-mail:haiyangliu@mail.kib.ac.cn
基金资助:
This work was financially supported by National Natural Science Foundation of China (Nos. 31600283 and 31570363) and fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2017-ZZ04) from Kunming Institute of Botany, Chinese Academy of Sciences.

Abstract

Abstract: Callisalignenes G-I (1-3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC₅₀ values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively.

Key words: Callistemon salignus, Myrtaceae, Meroterpenoids, Cytotoxicity

摘要： Callisalignenes G-I (1-3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC₅₀ values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively.

关键词: Callistemon salignus, Myrtaceae, Meroterpenoids, Cytotoxicity

Xu-Jie Qin, Tong Shu, Qian Yu, Huan Yan, Wei Ni, Lin-Kun An, Pan-Pan Li, Yin-E Zhi, Afsar Khan, Hai-Yang Liu. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus[J]. Natural Products and Bioprospecting, 2017, 7(4): 315-321.

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Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

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