Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

doi:10.1007/s13659-017-0137-7

Natural Products and Bioprospecting ›› 2017, Vol. 7 ›› Issue (4): 323-327.DOI: 10.1007/s13659-017-0137-7

• Original article • Previous Articles Next Articles

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Xin Wei^1,2,3, Afsar Khan^1,4, Da Song⁵, Zhi Dai^2,6, Ya-Ping Liu^1,3, Hao-Fei Yu^1,2,3, Bei Wang^1,2,3, Pei-Feng Zhu^1,2,3, Cai-Feng Ding^1,2,3, Xu-Dong Zhao⁶, Yi-Fen Wang^1,3, Xiao-Dong Luo^1,3

1. State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;
5. Yunnan College of Business Management, Kunming 650106, People's Republic of China;
6. Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People's Republic of China

Received:2017-06-05 Revised:2017-06-07 Online:2018-02-07 Published:2017-08-24
Supported by:
The authors are grateful to the National Natural Science Foundation of China (81225024) for financial support.

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Xin Wei^1,2,3, Afsar Khan^1,4, Da Song⁵, Zhi Dai^2,6, Ya-Ping Liu^1,3, Hao-Fei Yu^1,2,3, Bei Wang^1,2,3, Pei-Feng Zhu^1,2,3, Cai-Feng Ding^1,2,3, Xu-Dong Zhao⁶, Yi-Fen Wang^1,3, Xiao-Dong Luo^1,3

1. State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;
5. Yunnan College of Business Management, Kunming 650106, People's Republic of China;
6. Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People's Republic of China

通讯作者: Yi-Fen Wang,e-mail:wangyifen@mail.kib.ac.cn;Xiao-Dong Luo,e-mail:xdluo@mail.kib.ac.cn
基金资助:
The authors are grateful to the National Natural Science Foundation of China (81225024) for financial support.

Abstract

Abstract: Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3^# and GITC-18^#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.

Key words: Vinca major, Apocynaceae, Pyridine alkaloids, Cytotoxicity

摘要： Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3^# and GITC-18^#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.

关键词: Vinca major, Apocynaceae, Pyridine alkaloids, Cytotoxicity

Xin Wei, Afsar Khan, Da Song, Zhi Dai, Ya-Ping Liu, Hao-Fei Yu, Bei Wang, Pei-Feng Zhu, Cai-Feng Ding, Xu-Dong Zhao, Yi-Fen Wang, Xiao-Dong Luo. Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan[J]. Natural Products and Bioprospecting, 2017, 7(4): 323-327.

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Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

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