Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2015, Vol. 5 ›› Issue (2): 105-109.DOI: 10.1007/s13659-015-0059-1

• Original article • Previous Articles    

Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

Da-Song Yang1, Shuang-Mei Wang1, Wei-Bing Peng2, Yong-Ping Yang1, Ke-Chun Liu2, Xiao-Li Li1, Wei-Lie Xiao3   

  1. 1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
    2. Biology Institute of Shandong Academy of Sciences, Jinan 250014, People's Republic of China;
    3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China
  • Received:2015-01-27 Revised:2015-03-31 Online:2018-02-11 Published:2015-04-24
  • Supported by:
    This work was financially supported by National Natural Science Foundation of China(31300293 and 81422046), General Project of Applied Foundation Research, Yunnan Province(2013FB067), Basic Research Project of Ministry of Science and Technology of China(2012FY110300), Major State Basic Research Development Program(2010CB951704).

Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

Da-Song Yang1, Shuang-Mei Wang1, Wei-Bing Peng2, Yong-Ping Yang1, Ke-Chun Liu2, Xiao-Li Li1, Wei-Lie Xiao3   

  1. 1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
    2. Biology Institute of Shandong Academy of Sciences, Jinan 250014, People's Republic of China;
    3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China
  • 基金资助:
    This work was financially supported by National Natural Science Foundation of China(31300293 and 81422046), General Project of Applied Foundation Research, Yunnan Province(2013FB067), Basic Research Project of Ministry of Science and Technology of China(2012FY110300), Major State Basic Research Development Program(2010CB951704).

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Abstract: Three new minor prenylated flavonoids, named macadenanthins A-C(1-3), together with three known ones(4-6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines(MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range of 13.76-22.27 μM.

Key words: Macaranga adenantha, Prenylated Flavonoids, Macadenanthins A–C, Cytotoxicity

摘要： Three new minor prenylated flavonoids, named macadenanthins A-C(1-3), together with three known ones(4-6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines(MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range of 13.76-22.27 μM.

关键词: Macaranga adenantha, Prenylated Flavonoids, Macadenanthins A–C, Cytotoxicity

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