Abstract: Investigation on the cultures of Hypsizygus marmoreus resulted in the isolation of a new viscidane diterpene, 8-oxoviscida-3, 11(18)-diene-13, 14, 15, 19-tetraol(1) and two new polyacetylenes,(E)-10-(1, 1-dimethyl-2-propenyloxy)-2-decene-4, 6, 8-triyn-1-ol(2) and 10-(1, 1-dimethyl-2-propenyloxy) deca-4, 6, 8-triyn-1-ol(3), together with two known polyacetylenes,(E)-2-decen-4, 6, 8-triyn-1-ol(4) and 4, 6, 8-decatriyn-1-ol(5). Their structures were elucidated on the basis of extensive spectroscopic studies. Compound 1 is the first finding of viscidane diterpene in mushrooms. Compounds 1, 3 and 5 were tested for cytotoxicity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7 and SW-480. None of the compounds showed cytotoxic activity(IC₅₀>40 μM).

Key words: Hypsizygus marmoreus, Viscidane diterpene, Polyacetylenes

摘要： Investigation on the cultures of Hypsizygus marmoreus resulted in the isolation of a new viscidane diterpene, 8-oxoviscida-3, 11(18)-diene-13, 14, 15, 19-tetraol(1) and two new polyacetylenes,(E)-10-(1, 1-dimethyl-2-propenyloxy)-2-decene-4, 6, 8-triyn-1-ol(2) and 10-(1, 1-dimethyl-2-propenyloxy) deca-4, 6, 8-triyn-1-ol(3), together with two known polyacetylenes,(E)-2-decen-4, 6, 8-triyn-1-ol(4) and 4, 6, 8-decatriyn-1-ol(5). Their structures were elucidated on the basis of extensive spectroscopic studies. Compound 1 is the first finding of viscidane diterpene in mushrooms. Compounds 1, 3 and 5 were tested for cytotoxicity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7 and SW-480. None of the compounds showed cytotoxic activity(IC₅₀>40 μM).

关键词: Hypsizygus marmoreus, Viscidane diterpene, Polyacetylenes