Chemical investigation on the cultures of the fungus Xylaria carpophila

doi:10.1007/s13659-011-0011-y

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (2): 75-80.DOI: 10.1007/s13659-011-0011-y

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Chemical investigation on the cultures of the fungus Xylaria carpophila

Xia YIN^a,b, Tao FENG^a, Zheng-Hui LI^a, Jia SU^a, Yan LI^a, Ning-Hua TAN^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

Received:2011-08-05 Revised:2011-09-20 Online:2017-11-24 Published:2011-04-24
Supported by:
This project was supported by the National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Sciences Foundation of China(30830113), and MOST(2009ZX09501-029).

Chemical investigation on the cultures of the fungus Xylaria carpophila

Xia YIN^a,b, Tao FENG^a, Zheng-Hui LI^a, Jia SU^a, Yan LI^a, Ning-Hua TAN^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

通讯作者: Ji-Kai LIU,E-mail:jkliu@mail.kib.ac.cn
基金资助:
This project was supported by the National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Sciences Foundation of China(30830113), and MOST(2009ZX09501-029).

Abstract

Abstract: A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-_L-Phe-_L-Pro-_L-Leu-_D-Ile-_L-Val)(1), five new sesquiterpenes, named as xylcarpins A-E(2-6), and another known compound(7). The structures were determined by extensive NMR and MS spectroscopic analysis. The absolute configuration of 1 was established by use of Marfey's method and ROESY spectroscopic data. All compounds were tested for their cytotoxicities against five human cancer cell lines. Compound 7 showed week inhibitory activity.

Key words: Xylaria carpophila, sesquiterpenes, cyclopeptide, cytotoxicity

摘要： A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-_L-Phe-_L-Pro-_L-Leu-_D-Ile-_L-Val)(1), five new sesquiterpenes, named as xylcarpins A-E(2-6), and another known compound(7). The structures were determined by extensive NMR and MS spectroscopic analysis. The absolute configuration of 1 was established by use of Marfey's method and ROESY spectroscopic data. All compounds were tested for their cytotoxicities against five human cancer cell lines. Compound 7 showed week inhibitory activity.

关键词: Xylaria carpophila, sesquiterpenes, cyclopeptide, cytotoxicity

Xia YIN, Tao FENG, Zheng-Hui LI, Jia SU, Yan LI, Ning-Hua TAN, Ji-Kai LIU. Chemical investigation on the cultures of the fungus Xylaria carpophila[J]. Natural Products and Bioprospecting, 2011, 1(2): 75-80.

Xia YIN, Tao FENG, Zheng-Hui LI, Jia SU, Yan LI, Ning-Hua TAN, Ji-Kai LIU. Chemical investigation on the cultures of the fungus Xylaria carpophila[J]. 应用天然产物, 2011, 1(2): 75-80.

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Chemical investigation on the cultures of the fungus Xylaria carpophila

Chemical investigation on the cultures of the fungus Xylaria carpophila

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