Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (1): 48-51.DOI: 10.1007/s13659-011-0009-5

• Regular Article • Previous Articles     Next Articles

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Kang HEa,b, Yun-Bao MAa, Chang-An GENGa, Xue-Mei ZHANGa, Tuan-Wu CAOa,b, Fu-Qiang JIANGa,b, Ji-Jun CHENa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Graduate University of Chinese Academy of Sciences, Beijing 100039, China
  • Received:2011-07-08 Revised:2011-08-08 Online:2017-11-10 Published:2011-01-29
  • Supported by:
    This work was financially supported by the National Natural Sciences Foundation of China for Distinguished Young Scholar(No. 81025023). The authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for the measurements of all spectra.

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Kang HEa,b, Yun-Bao MAa, Chang-An GENGa, Xue-Mei ZHANGa, Tuan-Wu CAOa,b, Fu-Qiang JIANGa,b, Ji-Jun CHENa   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
    b Graduate University of Chinese Academy of Sciences, Beijing 100039, China
  • 通讯作者: Ji-Jun CHEN,E-mail:chenjj@mail.kib.ac.cn
  • 基金资助:
    This work was financially supported by the National Natural Sciences Foundation of China for Distinguished Young Scholar(No. 81025023). The authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for the measurements of all spectra.

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Abstract: Three new secoiridoids, swertiakoulactone(1) and swertiakosides A and B(2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus(HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion(IC50=1.10 mM, SI=4.39) and HBV DNA replication(IC50=1.16 mM, SI=4.12).

Key words: Swertia kouitchensis, anti-HBV activity, swertiakoulactone, swertiakoside A, swertiakoside B

摘要： Three new secoiridoids, swertiakoulactone(1) and swertiakosides A and B(2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus(HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion(IC50=1.10 mM, SI=4.39) and HBV DNA replication(IC50=1.16 mM, SI=4.12).

关键词: Swertia kouitchensis, anti-HBV activity, swertiakoulactone, swertiakoside A, swertiakoside B

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