Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

doi:10.1007/s13659-013-0059-y

Natural Products and Bioprospecting ›› 2013, Vol. 3 ›› Issue (5): 243-249.DOI: 10.1007/s13659-013-0059-y

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Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

Chang-An GENG, Xue-Mei ZHANG, Yun-Bao MA, Xiao-Yan HUANG, Ji-Jun CHEN

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Received:2013-07-20 Revised:2013-09-08 Online:2018-02-11 Published:2013-10-24
Supported by:
This work was funded by the National Natural Science Foundation of China and Yunnan Province (U0832603), the National Science Foundation of China for Distinguished Young Scholars (81025023), the West Light Foundation of the Chinese Academy of Sciences, the International Foundation for Science (No. F/5202-1), and the Youth Innovation Promotion Association, CAS.

Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

Chang-An GENG, Xue-Mei ZHANG, Yun-Bao MA, Xiao-Yan HUANG, Ji-Jun CHEN

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

通讯作者: Ji-Jun CHEN,E-mail:chenjj@mail.kib.ac.cn
基金资助:
This work was funded by the National Natural Science Foundation of China and Yunnan Province (U0832603), the National Science Foundation of China for Distinguished Young Scholars (81025023), the West Light Foundation of the Chinese Academy of Sciences, the International Foundation for Science (No. F/5202-1), and the Youth Innovation Promotion Association, CAS.

Abstract

Abstract: Eleven new secoiridoid aglycones involving unusual C₉-skeleton:swerimilegenins A-F (1-6); bis-C₉-skeleton:swerimilegenin G (7); and C₁₀-skeleton:swerimilegenins H-K (8-11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis. Their structures were determined by extensive spectroscopic data and X-ray diffraction. Biogenetically, swerimilegenin A (1) belonged to 10-nor-secoiridoid, and swerimilegenins B-F (2-6) were 1-nor-secoiridoids. Erythrocentaurin (12) and gentiogenal (15) showed moderate anti-HBV activity on HepG 2.2.15 cell line in vitro.

Key words: Swertia mileensis, swerimilegenins, secoiridoid aglycones, anti-HBV activity

摘要： Eleven new secoiridoid aglycones involving unusual C₉-skeleton:swerimilegenins A-F (1-6); bis-C₉-skeleton:swerimilegenin G (7); and C₁₀-skeleton:swerimilegenins H-K (8-11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis. Their structures were determined by extensive spectroscopic data and X-ray diffraction. Biogenetically, swerimilegenin A (1) belonged to 10-nor-secoiridoid, and swerimilegenins B-F (2-6) were 1-nor-secoiridoids. Erythrocentaurin (12) and gentiogenal (15) showed moderate anti-HBV activity on HepG 2.2.15 cell line in vitro.

关键词: Swertia mileensis, swerimilegenins, secoiridoid aglycones, anti-HBV activity

Chang-An GENG, Xue-Mei ZHANG, Yun-Bao MA, Xiao-Yan HUANG, Ji-Jun CHEN. Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis[J]. Natural Products and Bioprospecting, 2013, 3(5): 243-249.

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Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

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