Liao-Bin DONG, Juan HE, Xing-Yao LI, Xing-De WU, Xu DENG, Gang XU, Li-Yan PENG, Yu ZHAO, Yan LI, Xun GONG, Qin-Shi ZHAO
Phytochemical investigation of the aerial parts of the monotypic plant, Musella lasiocarpa, led to the isolation of four rare bicyclic diarylheptanoids, musellarins B-E(2-5), two new phenylphenalenones, 2-methoxy-9-(3', 4'-dihydroxyphenyl)-1H-phenalen-1-one(9), 2-methoxy-9-(3'-methoxy-4'-hydroxyphenyl)-1H-phenalen-1-one(10), a new acenaphtylene derivative, trans-(1S, 2S)-3-(4'-methoxyphenyl)-acenaphthene-1, 2-diol(13), and two new sucrose esters, 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16), 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17), together with nine known compounds. In addition,(4E, 6E)-1-(3', 4'-dihydroxyphenyl)-7-(4"-hydroxyphenyl)-hepta-4, 6-dien-3-one(15) was isolated for the first time from a natural source. The structures of new compounds were elucidated by analysis of their spectroscopic data. Compounds 2, 6, 8-10, 12, and 14 were cytotoxic toward several of the human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW480). Of these, the new compound 9 was the most potent one, with IC50 values of 5.8, 10.3, 6.3, 3.3, and 2.3 μM, respectively.
