Anti-inflammatory maistemonine-class alkaloids of Stemona japonica

doi:10.1007/s13659-023-00372-5

应用天然产物 ›› 2023, Vol. 13 ›› Issue (2): 8-8.DOI: 10.1007/s13659-023-00372-5

• Original Article • 上一篇下一篇

Anti-inflammatory maistemonine-class alkaloids of Stemona japonica

Cheng-Yong Tan^1,2, Bao-Bao Shi³, Mei-Fen Bao¹, Xiang-Hai Cai¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China;
3. School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan, 430074, People's Republic of China

收稿日期:2023-02-16 出版日期:2023-04-24 发布日期:2023-05-18
通讯作者: Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
基金资助:
This project was supported in part by the Xingdian Talent Support Plan and the Bualuang ASEAN Chair Professor Research Grant, Thailand.

Anti-inflammatory maistemonine-class alkaloids of Stemona japonica

Cheng-Yong Tan^1,2, Bao-Bao Shi³, Mei-Fen Bao¹, Xiang-Hai Cai¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China;
3. School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan, 430074, People's Republic of China

Received:2023-02-16 Online:2023-04-24 Published:2023-05-18
Contact: Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
Supported by:
This project was supported in part by the Xingdian Talent Support Plan and the Bualuang ASEAN Chair Professor Research Grant, Thailand.

摘要/Abstract

摘要： Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids. Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC₅₀ values of 19.7 and 13.8 μM, respectively, compared to positive control dexamethasone with 11.7 μM. The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.

关键词: Stemona japonica, Stemona alkaloids, Stemajapines A–C, Anti-inflammatory

Abstract: Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids. Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC₅₀ values of 19.7 and 13.8 μM, respectively, compared to positive control dexamethasone with 11.7 μM. The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.

Key words: Stemona japonica, Stemona alkaloids, Stemajapines A–C, Anti-inflammatory

Cheng-Yong Tan, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Anti-inflammatory maistemonine-class alkaloids of Stemona japonica[J]. 应用天然产物, 2023, 13(2): 8-8.

Cheng-Yong Tan, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Anti-inflammatory maistemonine-class alkaloids of Stemona japonica[J]. Natural Products and Bioprospecting, 2023, 13(2): 8-8.

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Anti-inflammatory maistemonine-class alkaloids of Stemona japonica

Anti-inflammatory maistemonine-class alkaloids of Stemona japonica

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