Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

doi:10.1007/s13659-019-00220-5

应用天然产物 ›› 2019, Vol. 9 ›› Issue (5): 311-328.DOI: 10.1007/s13659-019-00220-5

• REVIEW • 下一篇

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Rufin Marie Kouipou Toghueo

Antimicrobial and Biocontrol Agents Unit(AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon

收稿日期:2019-08-07 修回日期:2019-09-23 出版日期:2019-10-24 发布日期:2019-10-30
通讯作者: Rufin Marie Kouipou Toghueo
基金资助:
Rufin Marie Kouipou Toghueo is a postdoctoral researcher at the Drug Discovery Unit, University of Dundee. This integrated programme is developed by the Drug Discovery Unit with the support of the Wellcome Centre for Anti-Infective Research as a special programme for leadership research, capacity building, and training in drug discovery against tropical diseases.

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Rufin Marie Kouipou Toghueo

Antimicrobial and Biocontrol Agents Unit(AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon

Received:2019-08-07 Revised:2019-09-23 Online:2019-10-24 Published:2019-10-30
Contact: Rufin Marie Kouipou Toghueo
Supported by:
Rufin Marie Kouipou Toghueo is a postdoctoral researcher at the Drug Discovery Unit, University of Dundee. This integrated programme is developed by the Drug Discovery Unit with the support of the Wellcome Centre for Anti-Infective Research as a special programme for leadership research, capacity building, and training in drug discovery against tropical diseases.

摘要/Abstract

摘要： Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

关键词: Anti-leishmanial, Anti-inflammatory, Endophytes, Bioactive metabolites

Abstract: Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

Key words: Anti-leishmanial, Anti-inflammatory, Endophytes, Bioactive metabolites

Rufin Marie Kouipou Toghueo. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review[J]. 应用天然产物, 2019, 9(5): 311-328.

Rufin Marie Kouipou Toghueo. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review[J]. Natural Products and Bioprospecting, 2019, 9(5): 311-328.

参考文献

1. A.L. Harvey, R. Edrada-Ebel, R.J. Quinn, Nat. Rev. Drug Discov. 14, 111-129 (2015)
2. B. Shen, Cell 163, 1297-1300 (2015)
3. D.J. Newman, G.M. Cragg, J. Nat. Prod. 79, 629-661 (2016)
4. L. Katz, R.H. Baltz, J. Ind. Microbiol. Biotechnol. 43, 155-176 (2016)
5. N.P. Keller, Nat. Rev. Microbiol. (2018). https://doi.org/10.1038/s41579-018-0121-1
6. C.C. Thornburg, J.R. Britt, J.R. Evans, R.K. Akee, J.A. Whitt, S.K. Trinh, M.J. Harris, J.R. Thompson, T.L. Ewing, S.M. Shipley, P.G. Grothaus, D.J. Newman, J.P. Schneider, T. Grkovic, B.R. O'Keefe, A.C.S. Chem, Biol. (2018). https://doi.org/10.1021/acsch embio.8b003 89
7. G. Niu, W. Li, Trends Biochem. Sci. (2019). https://doi.org/10.1016/j.tibs.2019.05.005
8. G. Strobel, J. Fungi 4, 57 (2018)
9. M. Jia, L. Chen, H.-L. Xin, C.-J. Zheng, K. Rahman, T. Han, L.-P. Qin, Front. Microbiol. 7, 906 (2016)
10. H.F. Ji, X.J. Li, H.Y. Zhang, EMBO Rep. 10, 194-200 (2009). https://doi.org/10.1038/embor.2009.12
11. B. Joseph, R. MiniPriya, Am. J. Biochem. Mol. Biol. 3, 291-309 (2011)
12. K.R.M. Toghueo, Mycology. (2019). https://doi.org/10.1080/21501203.2019.16450 53
13. M.J. Allison, in Cambridge World History of Human Disease, ed. by K.F. Kiple (Cambridge University Press, Cambridge, 1993)
14. World Health Organization. Global Health Observatory (GHO) data. https://www.who.int/gho/neglected_diseases/leishmaniasis/en/(2018).
15. E. Hasker, S. Kansal, P. Malaviya, K. Gidwani, A. Picado, R.P. Singh, A. Chourasia, A.K. Singh, R. Shankar, J. Menten, M.E. Wilson, M. Boelaert, S. Sundar, PLoS Negl. Trop. Dis. 7(2), e2053 (2013)
16. S. Hewitt et al., Trans. R. Soc. Trop. Med. Hyg., 92, 273-274 (1998)
17. J. Alvar, P. Aparicio, A. Aseffa, M. Den Boer, C. Canavate, J.-P. Dedet, L. Gradoni, R. Ter Horst, R. Lopez-Velez, J. Moreno, Clin. Microbiol. Rev. 21, 334-359 (2008)
18. J. Alvar, I.D. Velez, C. Bern, M. Herrero, P. Desjeux, J. Cano, J. Jannin, M. den Boer, WHO Leishmaniasis Control Team. PLoS ONE 7, e35671 (2012)
19. S. Burza, R. Mahajan, P.K. Sinha, J. van Griensven, K. Pandey, M.A. Lima, M.G. Sanz, T. Sunyoto, S. Kumar, G. Mitra, PLoS Negl. Trop. Dis. 8, e3053 (2014)
20. S. Rijal, B. Ostyn, S. Uranw, K. Rai, N.R. Bhattarai, T.P.C. Dorlo, J.H. Beijnen, M. Vanaerschot, S. Decuypere, S.S. Dhakal, M.L. Das, P. Karki, R. Singh, M. Boelaert, J.-C. Dujardin, Clin. Infect. Dis. 56, 1530-1538 (2013). https://doi.org/10.1093/cid/cit102
21. T.P. Dorlo, et al., J. Infect. Dis. 210, 146-153 (2014)
22. M. Wasunna, S. Njenga, M. Balasegaram, N. Alexander, R. Omollo, T. Edwards, TP. Dorlo, B. Musa, MH. Ali, MY. Elamin, G. Kirigi, R. Juma, AE. Kip, GJ. Schoone, A.Hailu, J. Olobo, S. Ellis, R. Kimutai, S. Wells, E.A. Khalil, N. Strub Wourgaft, F. Alves, A. Musa, PLoS Negl. Trop. Dis. 10, e0004880 (2016)
23. J. Alvar, B. Arana, Drug Discovery for Leishmaniasis (The Royal Society of Chemistry, London, 2018)
24. S.J. Higginbotham, A.E. Arnold, A. Ibannez, C. Spadafora, P.D. Coley et al., PLoS ONE 8, e73192 (2013). https://doi.org/10.1371/journal.pone.0073192
25. H.L. Rosa, V.N. Gonçalves, RB. Caligiorne, T.M.A. Alves, A. Rabello, P.A. Sales, A.J. Romanha, M.E.G. Sobral, C.A. Rosa, CL. Zani, Braz. J. Microbiol. 41, 420-430 (2010)
26. S. Martínez-Luis, G. Della-Togna, P.D. Coley, T.A. Kursar, W.H. Gerwick, L. Cubilla-Rios, J. Nat. Prod. 71, 2011-2014 (2008). https://doi.org/10.1021/np800472q
27. H.E. Ortega, M. Teixeira Ede, A. Rabello, S. Higginbotham, L. Cubilla-Ríos, Nat. Prod. Commun. 9, 95-98 (2014)
28. E. Moreno, T. Varughese, C. Spadafora, A.E. Arnold, P.D. Coley, T.A. Kursar, W.H. Gerwick, L. Cubilla-Rios, Nat. Prod. Commun. 6, 835-840 (2011)
29. B.N. Lenta, J. Ngatchou, M. Frese, F. Ladoh-Yemeda, S. Voundi, F. Nardella, C. Michalek, D. Wibberg, S. Ngouela, E. Tsamo, M. Kaiser, J. Kalinowski, N. Sewald, Zeitschrift Für Naturforschung B 71, 1159-1167 (2016). https://doi.org/10.1515/znb-2016-0128
30. S.R. Ibrahim, H.M. Abdallah, G.A. Mohamed, S.A. Ross, Fitoterapia 112, 161-167 (2016)
31. E.S. Elkhayat, S.R. Ibrahim, G.A. Mohamed, S.A. Ross, Nat. Prod. Res. 30, 814-820 (2016)
32. F.F. Campos, L.H. Rosa, B.B. Cota, R.B. Caligiorne, A.L. Teles Rabello, et al., PLoS Negl. Trop. Dis. 2, e348 (2008). https://doi.org/10.1371/journal.pntd.0000348
33. A.M. do Nascimento, M.G. Soares, F.K. da Silva Torchelsen, J.A. de Araujo, P.S. Lage, M.C. Duarte, P.H. Andrade, T.G. Ribeiro, E.A. Coelho, World J. Microbiol. Biotechnol. 31, 1793-1800 (2015). https://doi.org/10.1007/s11274-015-1932-0
34. B.B. Cota, L.G. Tunes, D.N.B. Maia, J.P. Ramos, D.M. Oliveira, M. Kohlhoff, T.M.A. Alves, E.M. Souza-Fagundes, F.F. Campos, C.L. Zani, Mem. Inst. Oswaldo Cruz. 113, 102-110 (2018)
35. S. Martínez-Luis, L. Cherigo, E. Arnold, C. Spadafora, W.H. Gerwick, L. Cubilla-Rios, Nat. Prod. Commun. 7, 165-168 (2012)
36. A.M. Metwaly, H.A. Kadry, A.A. El-Hela, A.I. Mohammad, G. Ma, S.J. Cutler, S.A. Ross, Phytochem. Lett. 7, 1-5 (2014)
37. W.J. Andrioli, R. Conti, M.J. Araújo, R. Zanasi, B.C. Cavalcanti, V. Manfrim, J.S. Toledo, D. Tedesco, M.O. de Moraes, C. Pessoa, A.K. Cruz, C. Bertucci, J. Sabino, D.N. Nanayakkara, M.T. Pupo, J.K. Bastos, J. Nat. Prod. 77, 70-78 (2014). https://doi.org/10.1021/np4006822
38. T.T. de Almeida, M.A.D.S. Ribeiro, J.C. Polonio, F.P. Garcia, C.V. Nakamura, E.C. Meurer, M.H. Sarragiotto, D.C. Baldoqui, J.L. Azevedo, J.A. Pamphile, Nat. Prod. Res. 32, 2783-2790 (2018). https://doi.org/10.1080/14786419.2017.1380011
39. A.M. Zaher, M.A. Makboul, A.M. Moharram, B.L. Tekwani, A.I. Calderón, J. Antibiot. (Tokyo). 68, 197-200 (2015)
40. D.R. Alves, S.M. Morais, F. Tomiotto-Pellissier, F.R. Vasconcelos, FDCO. Freire, INGD. Silva, A.H.D. Cataneo, M.M. Miranda-Sapla, G.A.S. Pinto, I. Conchon-Costa, A.A.A. Noronha, W.R. Pavanelli, PLoS ONE. 13, e0196796 (2018). https://doi.org/10.1371/journal.pone.0196796
41. A.H. Tarawneh, F. León, M.M. Radwan, L.H. Rosa, S.J. Cutler, Nat. Prod. Commun. 8, 1285-1288 (2013)
42. G. Majno, The Healing Hand:Man and Wound in the Ancient World (Harvard University Press, Cambridge 1975)
43. R. Medzhitov, Cell 140, 771-776 (2010)
44. L. Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Y. Li, X. Wang, L. Zhao, Oncotarget. 9, 7204-7218 (2017)
45. E.M. Carvalho, R. Badaró, S.G. Reed, T.C. Jones, W.D. Johnson, J. Clin. Invest. 76, 2066-2069 (1985)
46. O. Bacellar, A. D'Oliveira, S. Jerônimo, E.M. Carvalho, Cytokine 12, 1228-1231 (2000)
47. A.S.A. Costa, G.C. Costa, D.M.C. de Aquino, V.R.R. de Mendonça, A. Barral, M. Barral-Netto, A.J.M. de Caldas, Mem. Do Inst. Osw. Cruz 107(6), 735-739 (2012)
48. D.S. Lima-Junior, D.L. Costa, V. Carregaro, L.D. Cunha, A.L.N. Silva, T.W.P. Mineo, F.R.S. Gutierrez, M. Bellio, R.K. Bortoluci, A.R. Flavell, T.M. Bozza, S.J. Silva, D.S. Zamboni, Nat. Med. 19(7), 909-915 (2013). https://doi.org/10.1038/nm.3221
49. V. Peruhype-Magalhães, O.A. Martins-Filho, A. Prata, L.D.A. Silva, A. Rabello, A. Teixeira-Carvalho, R.M. Figueiredo, S.F. Guimarães-Carvalho, T.C.A. Ferrari, J. Van Weyenbergh, R. Correa-Oliveira, Clin. Exp. Immun. 146, 124-132 (2006)
50. I.P. Barcelos, R.M. Troxell, J.S. Graves, Biology (Basel). 8, E37 (2019)
51. D.H. Tsai, M. Riediker, A. Berchet, F. Paccaud, G. Waeber, P. Vollenweider, M. Bochud, Environ. Sci. Pollut. Res. Int. 26, 19697-19704 (2019)
52. P. Deepak, J.E. Axelrad, A.N. Ananthakrishnan, Gastrointest. Endosc. Clin. N. Am. 29, 447-470 (2019)
53. R. Pahwa, I. Jialal, https://www.ncbi.nlm.nih.gov/books/NBK493173/(2019)
54. L.J. Crofford, Arthritis Res. Ther. 15, S2 (2013). https://doi.org/10.1186/ar4174
55. S. Wongrakpanich, A. Wongrakpanich, K. Melhado, J. Rangaswami Aging Dis. 9, 143-150 (2018). https://doi.org/10.14336/AD.2017.0306
56. A. Venieraki, M. Dimou, P. Katinakis, Hellenic Plant Prot. J. 10, 51-66 (2017)
57. C. Su, Q.L. Ming, K. Rahman, T. Han, L. Qin, Chin. J. Nat. Med. 13, 163-182 (2015)
58. W. Chen, G. Chen, Danshen Curr. Pharm. Des. 23, 5125-5135 (2017)
59. G.W. Fan, X.M. Gao, H. Wang, Y. Zhu, J. Zhang, L.M. Hu et al., J. Steroid Biochem. 113, 275-280 (2009). https://doi.org/10.1016/j.jsbmb.2009.01.011
60. Z. Jiang, W. Gao, L. Huang, Front. Pharm. (2019). https://doi.org/10.3389/fphar.2019.00202
61. Q. Ming, T. Han, W. Li, Q. Zhang, H. Zhang, C. Zheng, F. Huang, K. Rahman, L. Qin, Phytomedicine 19, 330-333 (2012). https://doi.org/10.1016/j.phyme d.2011.09.076
62. Q. Ming, C. Su, C. Zheng, M. Jia, Q. Zhang, H. Zhang, K. Rahman, T. Han, L. Qin, J. Exp. Bot. 64, 5687-5694 (2013). https://doi.org/10.1093/jxb/ert342
63. J.H. Ho, C.Y. Hong, J. Biomed. Sci. 18, 30 (2011). https://doi.org/10.1186/1423-0127-18-30
64. X. Li, X. Zhai, Z. Shu, R. Dong, Q. Ming, L. Qin, C. Zheng, Curr. Microbiol. 73(1), 31-37 (2016). https://doi.org/10.1007/s00284-016-1023-y
65. A.M. Mujumdar, J.N. Dhuley, V.K. Deshmukh, P.H. Raman, S.R. Naik, Jpn. J. Med. Sci. Biol. 43, 95-100 (1990)
66. J.R. Stohr, P.G. Xiao, R. Bauer, J. Ethnopharmacol. 75, 133-139 (2001)
67. J.S. Bang, D.H. Oh, H.M. Choi, B.J. Sur, S.J. Lim, J.Y. Kim, H.I. Yang, M.C. Yoo, D.H. Hahm, K.S. Kim, Arthritis Res. Ther. 11, R49 (2009). https://doi.org/10.1186/ar2662
68. S. Chithra, B. Jasim, P. Sachidanandan, M. Jyothis, E.K. Radhakrishnan, Phytomedicine 21, 534-540 (2014). https://doi.org/10.1016/j.phymed.2013.10.020
69. V. Mahajan, N. Sharma, S. Kumar, V. Bhardwaj, A. Ali, R.K. Khajuria, Y.S. Bedi, R.A. Vishwakarma, S.G. Gandhi, Pharm. Biol. 53, 446-450 (2015)
70. S.K. Jain, S.B. Bharate, R.A. Vishwakarma, Mini-Rev. Med. Chem. 12, 632-649 (2012)
71. U.K. Schmerwitz, G. Sass, A.G. Khandoga, J. Joore, B.A. Mayer, N. Berberich, F. Totzke, F. Krombach, G. Tiegs, S. Zahler, A.M. Vollmar, R. Fürst, Arterioscler. Thromb. Vasc. Biol. 3, 280-288 (2011)
72. P. Mohana Kumara, S. Zuehlke, V. Priti, B.T. Ramesha, S. Shweta, G. Ravikanth, R. Vasudeva, T.R. Santhoshkumar, M. Spiteller, R. Uma Shaanker, Antonie Van Leeuwenhoek 101, 323-329 (2012) https://doi.org/10.1007/s10482-011-9638-2
73. P.M. Kumara, K.N. Soujanya, G. Ravikanth, R. Vasudeva, K.N.Ganeshaiah, R. Uma Shaanker, Phytomedicine 21, 541-546 (2014)
74. X. You, S. Feng, S. Luo, D. Cong, Z. Yu, Z. Yang, J. Zhang, Fitoterapia 85, 161-168 (2013)
75. A. Harun, S. Vidyadaran, S.M. Lim, A.L. Cole, K. Ramasamy, BMC Complement Altern. Med. 15, 166 (2015). https://doi.org/10.1186/s12906-015-0685-5
76. N. Abutaha, A. Semlali, A. Baabbad, M. Al-Shami, M. Alanazi, M.A. Wadaan, Pak. J. Pharm. Sci. 31, 421-427 (2018)
77. M. Govindappa, R. Channabasava, D. Sowmya, J. Meenakshi, M. Shreevidya, A. Lavanya, T. Sadananda, Pharmacognosy J. 3, 82-90 (2011)
78. S. Shoba, M. Sathiavelu, Indian J. Pharm. Edu. Res 52, 2747-3283 (2018)
79. B.S. de Barros, J.P. da Silva, J.N. de Souza Ferro, I.K. Agra, F. de Almeida Brito, E.D. Albuquerque, LC. Caetano, E. Barreto, J. Nat. Med. 65, 526-531 (2011)
80. A.M. Abdel-Azeem, S.M. Zaki, W.F. Khalil, N.A. Makhlouf, L.M. Farghaly, Front. Microbiol. 7, 1477 (2016)
81. K. Ruma, K. Sunil, H.S. Prakash, Pharm. Biol. 52, 665-676 (2014)
82. Q. Zhang, R. Luan, H. Li, Y. Liu, P. Liu, L. Wang, D. Li, M. Wang, Q. Zou, H. Liu, K. Matsuzaki, F. Zhao, Exp. Ther. Med. 16, 1538-1546 (2018). https://doi.org/10.3892/etm.2018.6294
83. G. Ding, Y. Li, S. Fu, S. Liu, J. Wei, Y. Che, J. Nat. Prod. 72, 182-186 (2009)
84. R. Lin, H. Kim, J. Hong, Q.J. Li, A.C.S. Med, Chem. Lett. 5, 485-490 (2014)
85. W.-G. Lee, W.-S. Kim, S.-G. Park, H. Kim, J. Hong, H. Ko, Y.-C. Kim, ChemMedChem 7, 218-222 (2011). https://doi.org/10.1002/cmdc.201100409
86. A. Pretsch, M. Nagl, K. Schwendinger, B. Kreiseder, M. Wiederstein, D. Pretsch, M. Genov, R. Hollaus, D. Zinssmeister, A. Debbab, H. Hundsberger, A. Eger, P. Proksch, C. Wiesner, PLoS ONE 9, e97929 (2014). https://doi.org/10.1371/journal.pone.0097929
87. D.S. El-Agamy, S.R.M. Ibrahim, N. Ahmed, S. Khoshhal, H.M. Abo-Haded, M.A. Elkablawy, N. Aljuhani, G.A. Mohamed, Int. Immunopharmacol. 72, 429-436 (2019)
88. F. Guo, Z. Li, X. Xu, K. Wang, M. Shao, F. Zhao, H. Wang, H. Hua, Y. Pei, J. Bai, Fitoterapia 113, 44-50 (2016). https://doi.org/10.1016/j.fitote.2016.06.014
89. H. Xue, Q. Xu, C. Lu, Y. Shen, Drug Discov. Ther. 8, 208-211 (2014)
90. C. Qi, W. Gao, J. Wang, M. Liu, J. Zhang, C. Chen, Z. Hu, Y. Xue, D. Li, Q. Zhang, Y. Lai, Q. Zhou, H. Zhu, Y. Zhang, Fitoterapia 130, 134-139 (2018)
91. Y.S. Shi, Y. Zhang, X.Z. Chen, N. Zhang, Y.B. Liu, Molecules 20, 10793-10799 (2015)
92. S.K. Deshmukh, P.D. Mishra, A. Kulkarni-Almeida, S. Verekar, M.R. Sahoo, G. Periyasamy, H. Goswami, A. Khanna, A. Balakrishnan, R. Vishwakarma, Chem. Biodivers. 6, 784-789 (2009)
93. X. Wang, D.E. Wedge, S.J. Cutler, Nat. Prod. Commun. 11, 1595-1600 (2016)
94. D. Weber, O. Sterner, T. Anke, S. Gorzalczancy, V. Martino, C. Acevedo, J. Antibiot. 57, 559-563 (2004)
95. B.C. Yan, W.G. Wang, D.B. Hu, X. Sun, L.M. Kong, X.N. Li, X. Du, S.H. Luo, Y. Liu, Y. Li, H.D. Sun, J.X. Pu, Org. Lett. 18, 1108-1111 (2016). https://doi.org/10.1021/acs.orglett.6b00214
96. Z. Hu, Y. Wu, S. Xie, W. Sun, Y. Guo, X.N. Li, J. Liu, H. Li, J. Wang, Z. Luo, Y. Xue, Y. Zhang, Org. Lett. 19, 258-261 (2017). https://doi.org/10.1021/acs.orglett.6b03557
97. W. Li, C. Lee, S.H. Bang, J.Y. Ma, S. Kim, Y.S. Koh, S.H. Shim, J. Nat. Prod. 80, 205-209 (2017)
98. D. Zhang, H. Ge, J.H. Zou, X. Tao, R. Chen, J. Dai, Org. Lett. 16, 1410-1413 (2014)
99. K.L. Handore, P.D. Jadhav, B. Hazra, A. Basu, D.S. Reddy, A.C.S. Med, Chem. Lett. 6, 1117-1121 (2015). https://doi.org/10.1021/acsmedchemlett.5b00241
100. M.B. Gallo, M.J. Falso, F. Balem, D. Menezes, N. Rocha, R. Balachandran, T.S. Sturgeon, M.T. Pupo, B.W. Day, Planta Med. 80, 473-481 (2014). https://doi.org/10.1055/s-0034-1368301
101. J.R. Gubiani, M.L. Zeraik, C.M. Oliveira, V.F. Ximenes, C.R. Nogueira, L.M. Fonseca, D.H. Silva, V.S. Bolzani, A.R. Araujo, J. Nat. Prod. 77, 668-672 (2014). https://doi.org/10.1021/np400825s
102. J.W. Kim, H.G. Choi, J.H. Song, K.S. Kang, S.H. Shim, J. Antibiot. (2018). https://doi.org/10.1038/s41429-018-0131-2
103. U.J. Youn, T. Sripisut, E.J. Park, T.P. Kondratyuk, N. Fatima, C.J. Simmons, M.M. Wall, D. Sun, J.M. Pezzuto, L.C. Chang, Bioorg. Med. Chem. Lett. 25, 4719-4723 (2015)
104. K. Pudhom, T. Teerawatananond, J. Nat. Prod. 77, 1962-1966 (2014). https://doi.org/10.1021/np500068y
105. M. Zhao, L.Y. Yuan, D.L. Guo, Y. Ye, Z.M. Da-Wa, X.L. Wang, F.W. Ma, L. Chen, Y.C. Gu, L.S. Ding, Y. Zhou, Phytochemistry 148, 97-103 (2018)
106. W. Liu, S. Chen, J. Li, X. Yang, C. Yan, H. Liu, Nat. Prod. Res. 33, 354-359 (2019)
107. H.S. Chang, C.H. Lin, Y.S. Chen, H.C. Wang, H.Y. Chan, S.Y. Hsieh, H.C. Wu, M.J. Cheng, G.F. Yuan, S.Y. Lin, Y.J. Lin, I.S. Chen, Int. J. Mol. Sci. 17, E1512 (2016). https://doi.org/10.3390/ijms17091512
108. Y. Liu, M.H. Yang, X.B. Wang, T.X. Li, L.Y. Kong, Fitoterapia 109, 119-124 (2016)
109. C. Yan, W. Liu, J. Li, Y. Deng, S. Chen, H. Liu, RSC Adv. 8, 14823-14828 (2018)
110. J.L. Zhao, M. Zhang, J.M. Liu, Z. Tan, R.D. Chen, K.B. Xie, J.G. Dai, J. Asian Nat. Prod. Res. 19, 1028-1035 (2017). https://doi.org/10.1080/10286020.2017.1285908
111. A.D. Souza, E. Rodrigues-Filho, A.Q. Souza, J.Q. Pereira, A.K. Calgarotto, V. Maso, S. Marangoni, S.L. Da Silva, Toxicon 51, 240-250 (2008)
112. S. Mahapatra, D. Banerjee, Carbohydr. Polym. 90, 683-689 (2012)
113. M. Govindappa, H. Farheen, C.P. Chandrappa, Channabasava, R.V. Rai, V.B. Raghavendra, Adv. Nat. Sci 7, 035014 (2016). https://doi.org/10.1088/2043-6262/7/3/035014
114. W.C. Chi, K.L. Pang, W.L. Chen, G.J. Wang, T.H. Lee, Bot. Stud. 60, 4 (2019)
115. M.S. Lee, S.W. Wang, G.J. Wang, K.L. Pang, C.K. Lee, Y.H. Kuo, H.J. Cha, R.K. Lin, T.H. Lee, J. Nat. Prod. 79, 2983-2990 (2016). https://doi.org/10.1021/acs.jnatprod.6b00407
116. S. Chen, M. Ding, W. Liu, X. Huang, Z. Liu, Y. Lu, H. Liu, Z. She, Phytochemistry 146, 8-15 (2018). https://doi.org/10.1016/j.phytochem.2017.11.011
117. Y. Chen, Z. Liu, H. Liu, Y. Pan, J. Li, L. Liu, Z. She, Mar. Drugs 16, 54 (2018)
118. H. Chen, M. Huang, X. Li, L. Liu, B. Chen, J. Wang, Y. Lin, Fitoterapia 124, 103-107 (2018)
119. Z. Liu, P. Qiu, J. Li, G. Chen, Y. Chen, H. Liu, Z. She, Tetrahedron 74, 746-751 (2018)
120. Z. Liu, H. Liu, Y. Chen, Z. She, Nat. Prod. Res. 32, 2652-2656 (2018)
121. H. Cui, Y. Liu, J. Li, X. Huang, T. Yan, W. Cao, H. Liu, Y. Long, Z. She, J. Org. Chem. 83, 11804-11813 (2018). https://doi.org/10.1021/acs.joc.8b01738
122. H. Cui, Y. Liu, T. Li, Z. Zhang, M. Ding, Y. Long, Z. She, Fitoterapia 124, 177-181 (2018). https://doi.org/10.1016/j.fitote.2017.11.006
123. S. Chen, Z. Liu, H. Liu, Y. Long, D. Chen, Y. Lu, Z. She, Org. Biomol. Chem. 15, 6338-6341 (2017). https://doi.org/10.1039/c7ob01657c
124. C. Lee, S. Kim, W. Li, S. Bang, H. Lee, H.-J. Lee, E-Y. Noh, J-E. Jung-Eun Park, W.Y. Bang, S.H. Shim, J. Antibiot. 70, 737-742 (2017). https://doi.org/10.1038/ja.2017.39
125. M. Zhang, J.L. Zhao, J.M. Liu, R.D. Chen, K.B. Xie, D.W. Chen, K.P. Feng, D. Zhang, J.G. Dai, J. Asian Nat. Prod. Res. 19, 651-658 (2017). https://doi.org/10.1080/10286020.2016.1251908
126. Z.R. Ju, X. Qin, X.P. Lin, J.F. Wang, K. Kaliyaperumal, Y.Q. Tian, J. Liu, F. Liu, Z. Tu, S.H. Xu, Y. Liu, Nat. Prod. Res. 30, 192-198 (2016). https://doi.org/10.1080/14786419.2015.1050670
127. T.H. Quang, D.C. Kim, P. Van Kiem, C. Van Minh, N.X. Nhiem, B.H, Tai, P.H. Yen, N. Thi Thanh Ngan, H.J. Kim, H. Oh, J. Antibiot. 71, 826-830 (2018) https://doi.org/10.1038/s41429-018-0073-8.
128. H. Dou, Y. Song, X. Liu, W. Gong, E. Li, R. Tan, Y. Hou, Biol. Pharm. Bull. 34, 1864-1873 (2011)
129. T. Taechowisan, C. Lu, Y. Shen, S. Lumyong, Nat. Prod. Res. 21, 1104-1113 (2007)
130. T. Taechowisan, C. Lu, Y. Shen, S. Lumyong, Ann. Microbiol. 55, 63 (2005)
131. L. Rahman, Z.K. Shinwari, I. Iqrar, L. Rahman, F. Tanveer, Ann. Clin. Microbiol. Antimicrob. 16, 53 (2017). https://doi.org/10.1186/s12941-017-0228-7

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Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

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