Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

doi:10.1007/s13659-023-00369-0

应用天然产物 ›› 2023, Vol. 13 ›› Issue (1): 6-6.DOI: 10.1007/s13659-023-00369-0

• REVIEW • 上一篇

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Si¹, Jia Xiao¹, Xi¹, Ke Xu², Wei Chen¹, Jia¹, Yun Xin¹

1 Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Yangpu District, Shanghai 200433, China;
2 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

收稿日期:2022-12-06 出版日期:2023-02-24 发布日期:2023-03-08
通讯作者: Xian-Peng Zu,E-mail:zuxianpeng@163.com;Yun-Heng Shen,E-mail:shenyunheng@hotmail.com
基金资助:
The study was funded by the National Natural Science Foundation of China (82004215, 82173704, 31870327, 82003624, 82004003), the Key Research and Development Program of China (2019YFC1711006, 2017YFC1702002), the National Major Project of China (2018ZX09731016-005), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (16DZ2280200), Shanghai Municipal Health Commission Project (20204Y0326), Science and Technology Commission of Shanghai Municipality (20YF1459000, 20YF1458700) and Sailing Program of Naval Medical University.

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Si¹, Jia Xiao¹, Xi¹, Ke Xu², Wei Chen¹, Jia¹, Yun Xin¹

1 Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Yangpu District, Shanghai 200433, China;
2 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

Received:2022-12-06 Online:2023-02-24 Published:2023-03-08
Contact: Xian-Peng Zu,E-mail:zuxianpeng@163.com;Yun-Heng Shen,E-mail:shenyunheng@hotmail.com
Supported by:
The study was funded by the National Natural Science Foundation of China (82004215, 82173704, 31870327, 82003624, 82004003), the Key Research and Development Program of China (2019YFC1711006, 2017YFC1702002), the National Major Project of China (2018ZX09731016-005), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (16DZ2280200), Shanghai Municipal Health Commission Project (20204Y0326), Science and Technology Commission of Shanghai Municipality (20YF1459000, 20YF1458700) and Sailing Program of Naval Medical University.

摘要/Abstract

摘要： Euodiae Fructus, referred to as “Wuzhuyu” in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anticardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.

关键词: Euodiae Fructus, Traditional uses, Phytochemistry, Pharmacology, Toxicology

Abstract: Euodiae Fructus, referred to as “Wuzhuyu” in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anticardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.

Key words: Euodiae Fructus, Traditional uses, Phytochemistry, Pharmacology, Toxicology

Si, Jia Xiao, Xi, Ke Xu, Wei Chen, Jia, Yun Xin, Wen, Lin Yuan, Xian, Peng Zu, and Yun, Heng Shen. Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control[J]. 应用天然产物, 2023, 13(1): 6-6.

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Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

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