Natural Products in Cancer Therapy: Past, Present and Future

doi:10.1007/s13659-020-00293-7

应用天然产物 ›› 2021, Vol. 11 ›› Issue (1): 5-13.DOI: 10.1007/s13659-020-00293-7

Natural Products in Cancer Therapy: Past, Present and Future

Min Huang^1,2, Jin-Jian Lu³, Jian Ding^1,2

1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;
2 University of Chinese Academy of Sciences, Beijing, China;
3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

收稿日期:2020-10-15 修回日期:2020-12-15 出版日期:2021-02-24 发布日期:2021-03-11
通讯作者: Jian Ding
基金资助:
The authors thank Zi-Han Ye and Wei-Bang Yu for the assistance in preparing the figures.

Natural Products in Cancer Therapy: Past, Present and Future

Min Huang^1,2, Jin-Jian Lu³, Jian Ding^1,2

1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;
2 University of Chinese Academy of Sciences, Beijing, China;
3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

Received:2020-10-15 Revised:2020-12-15 Online:2021-02-24 Published:2021-03-11
Contact: Jian Ding
Supported by:
The authors thank Zi-Han Ye and Wei-Bang Yu for the assistance in preparing the figures.

摘要/Abstract

摘要： Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

关键词: Natural products, Cancer therapy, Drug discovery, Antibody-drug conjugates, Combination therapy

Abstract: Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

Key words: Natural products, Cancer therapy, Drug discovery, Antibody-drug conjugates, Combination therapy

Min Huang, Jin-Jian Lu, Jian Ding. Natural Products in Cancer Therapy: Past, Present and Future[J]. 应用天然产物, 2021, 11(1): 5-13.

Min Huang, Jin-Jian Lu, Jian Ding. Natural Products in Cancer Therapy: Past, Present and Future[J]. Natural Products and Bioprospecting, 2021, 11(1): 5-13.

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Natural Products in Cancer Therapy: Past, Present and Future

Natural Products in Cancer Therapy: Past, Present and Future

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