On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

doi:10.1007/s13659-020-00266-w

应用天然产物 ›› 2021, Vol. 11 ›› Issue (1): 15-20.DOI: 10.1007/s13659-020-00266-w

On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

Feng-Peng Wang, Ruo-Bing Chao

Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China

收稿日期:2020-08-10 修回日期:2020-09-16 出版日期:2021-02-24 发布日期:2021-03-11
通讯作者: Feng-Peng Wang, Ruo-Bing Chao
基金资助:
We gratefully acknowledge Professor Chun-Tao Che of the College of Pharmacy, University of Illinois at Chicago for careful review and polish of this manuscript. We also would like to thank Dr. Qi-Feng Chen (Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York. USA) for helpful assistance in writing this manuscript.

On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

Feng-Peng Wang, Ruo-Bing Chao

Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China

Received:2020-08-10 Revised:2020-09-16 Online:2021-02-24 Published:2021-03-11
Contact: Feng-Peng Wang, Ruo-Bing Chao
Supported by:
We gratefully acknowledge Professor Chun-Tao Che of the College of Pharmacy, University of Illinois at Chicago for careful review and polish of this manuscript. We also would like to thank Dr. Qi-Feng Chen (Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York. USA) for helpful assistance in writing this manuscript.

摘要/Abstract

摘要： This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.

关键词: Fu Zi, Aconitum carmichaelii, Diterpenoid alkaloid, Mesaconine

Abstract: This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.

Key words: Fu Zi, Aconitum carmichaelii, Diterpenoid alkaloid, Mesaconine

Feng-Peng Wang, Ruo-Bing Chao. On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine[J]. 应用天然产物, 2021, 11(1): 15-20.

Feng-Peng Wang, Ruo-Bing Chao. On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine[J]. Natural Products and Bioprospecting, 2021, 11(1): 15-20.

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On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

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