应用天然产物 ›› 2020, Vol. 10 ›› Issue (1): 51-56.DOI: 10.1007/s13659-020-00232-6
• • 上一篇
Takashi Kamada1,2, Mary Lyn Johanis2, Shean-Yeaw Ng2, Chin-Soon Phan2, Monica Suleiman2, Charles S. Vairappan2
Takashi Kamada1,2, Mary Lyn Johanis2, Shean-Yeaw Ng2, Chin-Soon Phan2, Monica Suleiman2, Charles S. Vairappan2
摘要: New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia's liverwort Pleurozia subinfl ata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.