Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

doi:10.1007/s13659-021-00301-4

应用天然产物 ›› 2021, Vol. 11 ›› Issue (3): 357-364.DOI: 10.1007/s13659-021-00301-4

• ORIGINAL ARTICLES • 上一篇

Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

Yan-Ni Chen¹, Xiao Ding¹, Dong-Mei Li^1,3, Qing-Yun Lu^1,2, Shuai Liu^1,2, Ying-Yao Li^1,3, Ying-Tong Di¹, Xin Fang¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan University, Kunming, People's Republic of China

收稿日期:2021-01-21 修回日期:2021-02-25 出版日期:2021-06-24 发布日期:2021-06-04
通讯作者: Xin Fang, Xiao-Jiang Hao
基金资助:
This research was supported by the National Natural Science Foundation of China under Grant (Numbers 21432010; 31872666; 82073740); National Key R&D Program of China under Grant (Number 2018YFA0900600); Technological leading talent project of Yunnan (2015HA020); Special Fund for Talent Introduction of Kunming Institute of Botany, CAS (to Xin Fang); and Key R&D Program of Yunnan under Grant (2019ZF011-2).

Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

Yan-Ni Chen¹, Xiao Ding¹, Dong-Mei Li^1,3, Qing-Yun Lu^1,2, Shuai Liu^1,2, Ying-Yao Li^1,3, Ying-Tong Di¹, Xin Fang¹, Xiao-Jiang Hao¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan University, Kunming, People's Republic of China

Received:2021-01-21 Revised:2021-02-25 Online:2021-06-24 Published:2021-06-04
Contact: Xin Fang, Xiao-Jiang Hao
Supported by:
This research was supported by the National Natural Science Foundation of China under Grant (Numbers 21432010; 31872666; 82073740); National Key R&D Program of China under Grant (Number 2018YFA0900600); Technological leading talent project of Yunnan (2015HA020); Special Fund for Talent Introduction of Kunming Institute of Botany, CAS (to Xin Fang); and Key R&D Program of Yunnan under Grant (2019ZF011-2).

摘要/Abstract

摘要： Euphopepluanones F-K (1-4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5-12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1-4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway.

关键词: Euphorbia peplus, Jatrophane, Lysosomal biogenesis activity, Macrocyclic diterpenoid

Abstract: Euphopepluanones F-K (1-4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5-12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1-4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway.

Key words: Euphorbia peplus, Jatrophane, Lysosomal biogenesis activity, Macrocyclic diterpenoid

Yan-Ni Chen, Xiao Ding, Dong-Mei Li, Qing-Yun Lu, Shuai Liu, Ying-Yao Li, Ying-Tong Di, Xin Fang, Xiao-Jiang Hao. Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway[J]. 应用天然产物, 2021, 11(3): 357-364.

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Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

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