The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

doi:10.1007/s13659-021-00311-2

应用天然产物 ›› 2021, Vol. 11 ›› Issue (5): 489-544.DOI: 10.1007/s13659-021-00311-2

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

Patrick O. Sakyi^1,2, Richard K. Amewu¹, Robert N. O. A. Devine², Emahi Ismaila², Whelton A. Miller^3,4,5, Samuel K. Kwofie^6,7

1 Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P. O. BOX LG 56, Legon, Accra, Ghana;
2 Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, Box 214, Sunyani, Ghana;
3 Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA;
4 Department of Molecular Pharmacology and Neuroscience, Loyola University Medical Center, Maywood, IL 60153, USA;
5 Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA;
6 Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, Ghana;
7 Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, P. O. Box LG 54, Accra, Ghana

收稿日期:2021-02-11 出版日期:2021-10-24 发布日期:2021-09-27
通讯作者: Samuel K. Kwofie

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

Patrick O. Sakyi^1,2, Richard K. Amewu¹, Robert N. O. A. Devine², Emahi Ismaila², Whelton A. Miller^3,4,5, Samuel K. Kwofie^6,7

1 Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P. O. BOX LG 56, Legon, Accra, Ghana;
2 Department of Chemical Sciences, School of Sciences, University of Energy and Natural Resources, Box 214, Sunyani, Ghana;
3 Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA;
4 Department of Molecular Pharmacology and Neuroscience, Loyola University Medical Center, Maywood, IL 60153, USA;
5 Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA;
6 Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, Ghana;
7 Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, P. O. Box LG 54, Accra, Ghana

Received:2021-02-11 Online:2021-10-24 Published:2021-09-27
Contact: Samuel K. Kwofie

摘要/Abstract

摘要： Despite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC₅₀/EC₅₀, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance.

关键词: Chemotherapeutics, Chemoinformatics, Natural products, Cytotoxicity, Leishmaniasis, Phenotypic screening

Abstract: Despite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC₅₀/EC₅₀, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance.

Key words: Chemotherapeutics, Chemoinformatics, Natural products, Cytotoxicity, Leishmaniasis, Phenotypic screening

Patrick O. Sakyi, Richard K. Amewu, Robert N. O. A. Devine, Emahi Ismaila, Whelton A. Miller, Samuel K. Kwofie. The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade[J]. 应用天然产物, 2021, 11(5): 489-544.

参考文献

1. T.S. Tiuman, A.O. Santos, T. Ueda-Nakamura, B.P.D. Filho, C.V. Nakamura, Int. J. Infect. Dis. 15, (2011)
2. WHO (2020). https://www.Who.Int/News-Room/Fact-Sheets/Detail/Leishmaniasis
3. B. Pérez-Cabezas, P. Cecílio, T.B. Gaspar, F. Gärtner, R. Vasconcellos, A. Cordeiro-da-Silva, Front. Cell. Infect. Microbiol. 9, 30 (2019)
4. PAHO/WHO (2017). https://www.paho.org/hq/dmdocuments.
5. I. Okwor, J. Uzonna, Am. J. Trop. Med. Hyg. 94, 489 (2016)
6. R. Arenas, E. Torres-Guerrero, M. R. Quintanilla-Cedillo, and J. Ruiz-Esmenjaud, F1000Research 6, (2017).
7. N. Tiwari, M. R. Gedda, V. K. Tiwari, S. P. Singh, and R. K. Singh, Mini-Reviews Med. Chem. 18, (2018).
8. K. Jain, N.K. Jain, J. Immunol. Methods 422, 1 (2015)
9. S. Emami, P. Tavangar, M. Keighobadi, Eur. J. Med. Chem. 135, 241 (2017)
10. N. Dunning and S. Ali, Bioscience Horizons 2, (2009)
11. S. Srivastava, P. Shankar, J. Mishra, and S. Singh, Parasites and Vectors 9, (2016).
12. P. L. Olliaro, P. J. Guerin, S. Gerstl, A. A. Haaskjold, J. A. Rottingen, and S. Sundar, Lancet Infect. Dis. 5, 763 (2005).
13. P.L. Olliaro, P.J. Guerin, S. Gerstl, A.A. Haaskjold, J.A. Rottingen, S. Sundar, Lancet Infect. Dis. 5, 763 (2005)
14. J. N. Rugani, C. M. F. Gontijo, F. Frézard, R. P. Soares, and R. L. Do Monte-Neto, Mem. Inst. Oswaldo Cruz 114, (2019)
15. F. Frézard, R. Monte-Neto, P.G. Reis, Biophys. Rev. 6, 119 (2014)
16. G. Mandal, S. Mandal, M. Sharma, K.S. Charret, B. Papadopoulou, H. Bhattacharjee, R. Mukhopadhyay, PLoS Negl. Trop. Dis. 9, (2015)
17. S. Sundar, J. Chakravarty, Expert Opin. Pharmacother. 16, 237 (2015)
18. A.C.O. Souza, A.C. Amaral, Front. Microbiol. 8, 336 (2017)
19. A.S. Nagle, S. Khare, A.B. Kumar, F. Supek, A. Buchynskyy, C.J.N. Mathison, N.K. Chennamaneni, N. Pendem, F.S. Buckner, M.H. Gelb, V. Molteni, Chem. Rev. 114, 11305 (2014)
20. A. Tamiru, B. Tigabu, S. Yifru, E. Diro, A. Hailu, B.M.C. Infect, Dis. 16, 548 (2016)
21. J.R. Luque-Ortega, L. Rivas, Antimicrob. Agents Chemother. 51, 1327 (2007)
22. J. Pijpers, M. L. Den Boer, D. R. Essink, and K. Ritmeijer, PLoS Negl. Trop. Dis. 13, 1 (2019).
23. S. Sundar, J. Chakravarty, Expert Opin. Investig. Drugs 17, 787 (2008)
24. V. Wiwanitkit, Ther. Clin. Risk Manag. 8, 323 (2012)
25. W. Khan, R. Kumar, S. Singh, S.K. Arora, N. Kumar, Drug Test. Anal. 5, 468 (2013)
26. P.M. Loiseau, S. Cojean, J. Schrével, J. Parasite, La Société Fran-çaise Parasitol. 18, 115 (2011)
27. T.J. Gintjee, M.A. Donnelley, G.R. Thompson, J. Fungi 6, 28 (2020)
28. S.T. De Macedo-Silva, J.A. Urbina, W. De Souza, J.C.F. Rodrigues, PLoS ONE 8, (2013)
29. B.B. Mishra, V.K. Tiwari, Eur. J. Med. Chem. 46, 4769 (2011)
30. E. Patridge, P. Gareiss, M.S. Kinch, D. Hoyer, Drug Discov. Today 21, 204 (2016)
31. I. V. Ogungbe, M. Singh, and W. N. Setzer, Antileishmanial Natural Products from Plants, 1st ed. (Elsevier B.V., 2012)
32. D.B. Santana, R.C. da Costa, R.M. Araújo, J.E. de Paula, E.R. Silveira, R. Braz-Filho, L.S. Espindola, Brazilian. J. Pharmacogn. 25, 401 (2015)
33. C.V. Simoben, F. Ntie-Kang, S.H. Akone, W. Sippl, Nat. Products Bioprospect. 8, 151 (2018)
34. N. Ullah, A. Nadhman, S. Siddiq, S. Mehwish, A. Islam, L. Jafri, M. Hamayun, Phyther. Res. 30, 1905 (2016)
35. J. Búfalo, C.L. Cantrell, M.R. Jacob, K.K. Schrader, B.L. Tekwani, T.S. Kustova, A. Ali, C.S.F. Boaro, Planta Med. 82, 131 (2015)
36. D. Pulivarthi, K.M. Steinberg, L. Monzote, A. Piñón, W.N. Setzer, Nat. Prod. Commun. 10, 1229 (2015)
37. L. Scotti, H. Ishiki, F.J.B. Mendonca, M.S. Silva, M.T. Scotti, Mini-Reviews. Med. Chem. 15, 253 (2015)
38. R. Sen, M. Chatterjee, Phytomedicine 18, 1056 (2011)
39. S.K. Venkatesan, P. Saudagar, A.K. Shukla, V.K. Dubey, Interdiscip. Sci. Comput Life Sci. 3, 217 (2011)
40. R.S. Gabriel, A.C.F. Amaral, I.C. Lima, J.D. Cruz, A.R. Garcia, H.A.S. Souza, C.M. Adade, A.B. Vermelho, C.S. Alviano, D.S. Alviano, I.A. Rodrigues, Rev. Bras. Farmacogn. 29, 755 (2019)
41. B.B. Cota, L.H. Rosa, R.B. Caligiorne, A.L.T. Rabello, T.M. AlmeidaAlves, C.A. Rosa, C.L. Zani, FEMS Microbiol. Lett. 285, 177 (2008)
42. L.H. Rosa, V.N. Gonçalves, R.B. Caligiorne, T.M.A. Alves, A. Rabello, P.A. Sales, A.J. Romanha, M.E.G. Sobral, C.A. Rosa, C.L. Zani, Brazilian. J. Microbiol. 41, 420 (2010)
43. D. Pech-Puch, M. Pérez-Povedano, O.A. Lenis-Rojas, J. Rodríguez, C. Jiménez, Mar. Drugs 18, 59 (2020)
44. K. Hayibor, S. Kwain, E. Osei, A.P. Nartey, G.M. Tetevi, K.B.-A. Owusu, M. Camas, A.S. Camas, K. Kyeremeh, Int. J. Biol. Chem. Sci. 13, 1918 (2019)
45. M. M. Basyoni, Parasitol. United J. 5, (2012).
46. R. M. de Oliveira, S. de A. Melo, T. A. da Penha-Silva, F. Almeida-Souza, and A. L. Abreu-Silva, in Leishmaniases as Re-Emerging Dis. (InTech, 2018)
47. L.R.T. Yamthe, R. Appiah-Opong, P.V.T. Fokou, N. Tsabang, F.F. Boyom, A.K. Nyarko, M.D. Wilson, Mar. Drugs 15, 323 (2017)
48. I. A. Rodrigues, A. M. Mazotto, V. Cardoso, R. L. Alves, A. C. F. Amaral, J. R. D. A. Silva, A. S. Pinheiro, and A. B. Vermelho, Mediators Inflamm. 2015, (2015)
49. R.M.K. Toghueo, Nat. Products Bioprospect. 9, 311 (2019)
50. N. Fatima, S. Muhammad, A. Mumtaz, H. Tariq, I. Shahzadi, M. Said, M. Dawood, Br. J. Pharm. Res. 12, 1 (2016)
51. M. Oliveira, L. Barreira, K.N. Gangadhar, M.J. Rodrigues, T. Santos, J. Varela, L. Custódio, Phytochem. Rev. 15, 663 (2016)
52. E. C. Da Silva, C. D. Rayol, P. L. Medeiros, R. C. B. Q. Figueiredo, M. R. Piuvezan, J. M. Brabosa-Filho, A. Fernandes Marinho, T. G. Silva, G. C. G. Militão, A. P. P. Cassilhas, and P. P. De Andrade, Sci. World J. 2012, (2012)
53. L.R.C. Guimarães, A.P.D. Rodrigues, P.S.B. Marinho, A.H. Muller, G.M.S. Guilhon, L.S. Santos, J.L.M. Do Nascimento, E.O. Silva, Parasitol. Res. 107, 1075 (2010)
54. S. M. M. Amyra Amat Sain, Azimah Amanah, Zuriati Zahari, Roshan Jahn Mohd Salim, Int. J. Pharmacol. Phytochem. Ethnomedicine 3, 1 (2016).
55. N. Zhu, X. Cao, P. Hao, Y. Zhang, Y. Chen, J. Zhang, J. Li, C. Gao, L. Li, Cell Stress Chaperones 25, 417 (2020)
56. N. Zorić, I. Kosalec, S. Tomić, I. Bobnjarić, M. Jug, T. Vlainić, J. Vlainić, B.M.C. Complement, Altern. Med. 17, 268 (2017)
57. G.M. Tetevi, S. Kwain, T. Mensah, A.S. Camas, M. Camas, A.K. Dofuor, F.A. Azerigyik, E. Oluwabusola, H. Deng, M. Jaspars, K. Kyeremeh, Molbank 2019, M1094 (2019)
58. E. Osei, S. Kwain, G.T. Mawuli, A.K. Anang, K.B.A. Owusu, M. Camas, A.S. Camas, M. Ohashi, C.N. Alexandru-Crivac, H. Deng, M. Jaspars, K. Kyeremeh, Mar. Drugs 17, 9 (2019)
59. S.L. Shyaula, T. Tamang, N. Ghouri, A. Adhikari, S. Marasini, G.B. Bajracharya, M.D. Manandhar, M.I. Choudhary, Nat. Prod. Res. 30, 2590 (2016)
60. M.E. Ferreira, A. Rojas de Arias, G. Yaluff, N.V. de Bilbao, H. Nakayama, S. Torres, A. Schinini, I. Guy, H. Heinzen, A. Fournet, Phytomedicine 17, 375 (2010)
61. C.B. Naman, G. Gupta, S. Varikuti, H. Chai, R.W. Doskotch, A.R. Satoskar, A.D. Kinghorn, J. Nat. Prod. 78, 552 (2015)
62. A. M. Metwaly, M. M. Ghoneim, and A. Musa, Two new antileishmanial diketopiperazine alkaloids from the endophytic fungus Trichosporum Sp (2015)
63. T. Naz, A. Mosaddik, M.M. Rahman, I. Muhammad, M.E. Haque, S.K. Cho, Nat. Prod. Res. 26, 979 (2012)
64. A.D.C. Cunha, T.P.C. Chierrito, G.M.D.C. MacHado, L.L.P. Leon, C.C. Da Silva, J.C. Tanaka, L.M. De Souza, R.A.C. Gonalves, A.J.B. De Oliveira, Phytomedicine 19, 413 (2012)
65. A. Mollataghi, E. Coudiere, A.H.A. Hadi, M.R. Mukhtar, K. Awang, M. Litaudon, A. Ata, Fitoterapia 83, 298 (2012)
66. H. Mahmoudvand, S.A.A. Mousavi, A. Sepahvand, F. Sharififar, B. Ezatpour, F. Gorohi, E.S. Dezaki, S. Jahanbakhsh, ISRN Pharmacol. 2014, 1 (2014)
67. S. Ghosal, A. Deb, P. Mishra, R. Vishwakarma, Planta Med. 78, 906 (2012)
68. I. Orhan, B. Şener, M. Kaiser, R. Brun, D. Tasdemir, Mar. Drugs 8, 47 (2010)
69. L. Cartuche, I. Sifaoui, A. López-Arencibia, C.J. BethencourtEstrella, D.S. Nicolás-Hernández, J. Lorenzo-Morales, J.E. Piñero, A.R. Díaz-Marrero, J.J. Fernández, Biomolecules 10, 1 (2020)
70. Y.S. Rizk, A. Fischer, M.C. de Cunha, P.O. Rodrigues, M.C.S. Marques, M.F.C. de Matos, M.C.T. Kadri, C.A. Carollo, C.C.P. de Arruda, Mem. Inst. Oswaldo Cruz 109, 1050 (2014)
71. P.S. Lage, M.A. Chávez-Fumagalli, J.T. Mesquita, L.M. Mata, S.O.A. Fernandes, V.N. Cardoso, M. Soto, C.A.P. Tavares, J.P.V. Leite, A.G. Tempone, E.A.F. Coelho, Parasitol. Res. 114, 4625 (2015)
72. F. Fonseca-Silva, J.D.F. Inacio, M.M. Canto-Cavalheiro, E.E. Almeida-Amaral, PLoS ONE 6, (2011)
73. S.S. Grecco, T.A. Costa-Silva, G. Jerz, F.S. de Sousa, G.A.A. Conserva, J.T. Mesquita, M.K. Galuppo, A.G. Tempone, B.J. Neves, C.H. Andrade, R.L.O.R. Cunha, M. Uemi, P. Sartorelli, J.H.G. Lago, Phytomedicine 24, 62 (2017)
74. F.S. de Sousa, S.S. Grecco, N. Girola, R.A. Azevedo, C.R. Figueiredo, J.H.G. Lago, Phytochemistry 140, 108 (2017)
75. L.S. Morais, R.G. Dusi, D.P. Demarque, R.L. Silva, L.C. Albernaz, S.N. Bao, C. Merten, L.M.R. Antinarelli, E.S. Coimbra, L.S. Espindola, PLoS ONE 15, 1 (2020)
76. R. A. Falcao, P. L. A. Do Nascimento, S. A. De Souza, T. M. G. Da Silva, A. C. De Queiroz, C. B. B. Da Matta, M. S. A. Moreira, C. A. Camara, and T. M. S. Silva, Evidence-Based Complement. Altern. Med. 2013, (2013)
77. M. Alagawany, M.E.A. El-Hack, M.R. Farag, M. Gopi, K. Karthik, Y.S. Malik, K. Dhama, Anim. Health. Res. Rev. 18, 167 (2017)
78. V.K. Bajpai, M.B. Alam, K.T. Quan, M.K. Ju, R. Majumder, S. Shukla, Y.S. Huh, M.K. Na, S.H. Lee, Y.K. Han, Sci. Rep. 8, 9216 (2018)
79. R.F. Espírito-Santo, C.S. Meira, R. DosSantosCosta, O.P.S. Filho, A.F. Evangelista, G.H.G. Trossini, G.M. Ferreira, E.S. Da Velozo, C.F. Villarreal, M.B.P. Soares, PLoS ONE 12, 0179174 (2017)
80. W. Gao, Q. Li, J. Chen, Z. Wang, C. Hua, Molecules 18, 15613 (2013)
81. V. P. C. Rocha, C. Q. Da Rocha, E. F. Queiroz, L. Marcourt, W. Vilegas, G. B. Grimaldi, P. Furrer, E. Allémann, J. L. Wolfender, and M. B. P. Soares, Molecules 24, (2019)
82. M.M. Radwan, A.S. Wanas, F.R. Fronczek, M.R. Jacob, S.A. Ross, Med. Chem. Res. 24, 3398 (2015)
83. T.A. Da Costa-Silva, S.S. Grecco, F.S. De Sousa, J.H.G. Lago, E.G.A. Martins, C.A. Terrazas, S. Varikuti, K.L. Owens, S.M. Beverley, A.R. Satoskar, A.G. Tempone, J. Nat. Prod. 78, 653 (2015)
84. A. Kaur, R. Singh, C.S. Dey, S.S. Sharma, K.K. Bhutan, I.P. Singh, Indian J. Exp. Biol. 48, 314 (2010)
85. T.A. Da Costa-Silva, G.A.A. Conserva, A.J. Galisteo, A.G. Tempone, J.H.G. Lago, J. Venom. Anim. Toxins Incl. Trop. Dis. 25, 1 (2019)
86. M.C. Vendrametto, A.O. dos Santos, C.V. Nakamura, B.P.D. Filho, D.A.G. Cortez, T. Ueda-Nakamura, Parasitol. Int. 59, 154 (2010)
87. L.A.O. dos Ferreira, M.M. de Oliveira, F.L. Faleiro, D.B. Scariot, J.S. Boeing, J.V. Visentainer, M.B. Romagnolo, C.V. Nakamura, M.C.T. Truiti, Nat. Prod. Res. 32, 2825 (2018)
88. B.B. Mishra, J.K. Gour, N. Kishore, R.K. Singh, V. Tripathi, V.K. Tiwari, Nat. Prod. Res. 27, 480 (2013)
89. F.L. Dutra, M.M. Oliveira, R.S. Santos, W.S. Silva, D.S. Alviano, D.P. Vieira, A.H. Lopes, Acta Trop. 164, 69 (2016)
90. S.M. de Morais, N.S. Vila-Nova, C.M.L. Bevilaqua, F.C. Rondon, C.H. Lobo, A.A.A.N. De Moura, A.D. Sales, A.P.R. Rodrigues, J.R. De Figuereido, C.C. Campello, M.E. Wilson, H.F. De Andrade, Bioorganic. Med. Chem. 22, 6250 (2014)
91. T. Ueda-Nakamura, R.R. Mendonça-Filho, J.A. Morgado-Díaz, P.K. Maza, B.P.D. Filho, D.A.G. Cortez, D.S. Alviano, M.S.S. do Rosa, A.H.C.S. Lopes, C.S. Alviano, C.V. Nakamura, Parasitol. Int. 55, 99 (2006)
92. A.M. do Nascimento, M.G. Soares, F.K.V.S. da Torchelsen, J.A.V. de Araujo, P.S. Lage, M.C. Duarte, P.H.R. Andrade, T.G. Ribeiro, E.A.F. Coelho, A.M. do Nascimento, World J. Microbiol. Biotechnol. 31, 1793 (2015)
93. R. Parise-Filho, K.F.M. Pasqualoto, F.M.M. Magri, A.K. Ferreira, B.A.V.G. Da Silva, M.C.F.C.B. Damião, M.T. Tavares, R.A. Azevedo, A.V.V. Auada, M.C. Polli, C.A. Brandt, Arch. Pharm. (Weinheim). 345, 934 (2012)
94. L.G. Malak, M.A. Ibrahim, D.W. Bishay, A.M. Abdel-Baky, A.M. Moharram, B. Tekwani, S.J. Cutler, S.A. Ross, J. Nat. Prod. 77, 1987 (2014)
95. L.G. Malak, M.A. Ibrahim, A.M. Moharram, P. Pandey, B. Tekwani, R.J. Doerksen, D. Ferreira, S.A. Ross, J. Nat. Prod. 81, 2222 (2018)
96. S. Bashir, M. Alam, A. Adhikari, R.L. Shrestha, S. Yousuf, B. Ahmad, S. Parveen, A. Aman, M.I. Choudhary, Phytochem. Lett. 9, 46 (2014)
97. E.M. Maldonado, E. Salamanca, A. Giménez, G. Saavedra, O. Sterner, Phytochem. Lett. 10, 281 (2014)
98. B. Attioua, L. Lagnika, D. Yeo, C. Antheaume, M. Kaiser, B. Weniger, A. Lobstein, C. Vonthron-Sénécheau, Int. J. Pharm. Sci. Rev. Res. 11, 1 (2011)
99. R.S. Costa, O.P.S. Filho, O.C.S.D. Júnior, J.J. Silva, M. LeHyaric, M.A.V. Santos, E.S. Velozo, Braz. J. Pharmacogn. 28, 551 (2018)
100. A.O. dos Santos, E.A. Britta, E.M. Bianco, T. Ueda-Nakamura, B.P.D. Filho, R.C. Pereira, C.V. Nakamura, Mar. Drugs 9, 2369 (2011)
101. A. Santos, E. Britta, T. Ueda-Nakamura, B. D. Filho, E. Bianco, V. Teixeira, R. Pereira, and C. Nakamura, Planta Med. 75, (2009)
102. C. Garcia, C.O. Silva, C.M. Monteiro, M. Nicolai, A. Viana, J.M. Andrade, I. Barasoain, T. Stankovic, J. Quintana, I. Hernández, I. González, F. Estévez, A.M. Díaz-Lanza, C.P. Reis, C.A.M. Afonso, M. Pesic, P. Rijo, Future. Med. Chem. 10, 1177 (2018)
103. P. Sitarek, M. Toma, E. Ntungwe, T. Kowalczyk, E. Skała, J. Wieczfinska, T. Śliwiński, P. Rijo, Biomolecules 10, 194 (2020)
104. V.C. Desoti, D. Lazarin-Bidóia, D.B. Sudatti, R.C. Pereira, A. Alonso, T. Ueda-Nakamura, B.P.D. Filho, C.V. Nakamura, S.O. de Silva, Mar. Drugs 10, 1631 (2012)
105. Y. Freile-Pelegrín, D. Tasdemir, Bot. Mar. 62, 211 (2019)
106. A. V. Colares, F. Almeida-Souza, N. N. Taniwaki, C. D. S. F. Souza, J. G. M. Da Costa, K. D. S. Calabrese, and A. L. AbreuSilva, Evidence-Based Complement. Altern. Med. 2013, (2013)
107. S. Hajaji, I. Sifaoui, A. López-Arencibia, M. Reyes-Batlle, I.A. Jiménez, I.L. Bazzocchi, B. Valladares, H. Akkari, J. LorenzoMorales, J.E. Piñero, Parasitol. Res. 117, 2855 (2018)
108. G.S. Lima, D.B. Castro-Pinto, G.C. MacHado, M.A.M. Maciel, A. Echevarria, Phytomedicine 22, 1133 (2015)
109. M. Saleem, Cancer Lett. 285, 109 (2009)
110. Y.L. Liu, S. Lindert, W. Zhu, K. Wang, J.A. McCammon, E. Oldfield, Proc. Natl. Acad. Sci. USA 111, E2530 (2014)
111. Y. Jia, C. Wu, B. Zhang, Y. Zhang, J. Li, Hum. Exp. Toxicol. 38, 227 (2019)
112. K. Becker, S. Schwaiger, B. Waltenberger, D. Fuchs, C. K. Pezzei, H. Schennach, H. Stuppner, and J. M. Gostner, Oxid. Med. Cell. Longev. (2018).
113. D. Slameňová, I. Mašterová, J. Lábaj, E. Horváthová, P. Kubala, J. Jakubíková, L. Wsólová, Basic Clin. Pharmacol. Toxicol. 94, 282 (2004)
114. L. Monzote, A. Lackova, K. Staniek, O. Cuesta-Rubio, L. Gille, Parasitology 142, 1239 (2015)
115. L.A. Caldas, M.L. Yoshinaga, M.J.P. Ferreira, J.H.G. Lago, A.B. de Souza, M.D. Laurenti, L.F.D. Passero, P. Sartorelli, Bioorg. Chem. 83, 348 (2019)
116. H. Wu, F.R. Fronczek, C.L. Burandt, J.K. Zjawiony, Planta Med. 77, 749 (2011)
117. Y. Nakagawa, M. Iinuma, N. Matsuura, K. Yi, M. Naoi, T. Nakayama, Y. Nozawa, Y. Akao, J. Pharmacol. Sci. 97, 242 (2005)
118. N. Fakhrudin, B. Waltenberger, M. Cabaravdic, A.G. Atanasov, C. Malainer, D. Schachner, E.H. Heiss, R. Liu, S.M. Noha, A.M. Grzywacz, J. Mihaly-Bison, E.M. Awad, D. Schuster, J.M. Breuss, J.M. Rollinger, V. Bochkov, H. Stuppner, V.M. Dirsch, Br. J. Pharmacol. 171, 1676 (2014)
119. E.S. Yamamoto, B.L.S. Campos, J.A. Jesus, M.D. Laurenti, S.P. Ribeiro, E.G. Kallás, M. Rafael-Fernandes, G. Santos-Gomes, M.S. Silva, D.P. Sessa, J.H.G. Lago, D. Levy, L.F.D. Passero, PLoS ONE 10, (2015)
120. B. Attioua, D. Yeo, L. Lagnika, R. Harisolo, C. Antheaume, B. Weniger, M. Kaiser, A. Lobstein, C. Vonthron-Sénécheau, Pharm. Biol. 50, 801 (2012)
121. F.A. Azerigyik, M. Amoa-Bosompem, T. Tetteh, F. Ayertey, A.N. Antwi, K.B.-A. Owusu, K.K. Dadzie, G.I. Djameh, M. TettehTsifoanya, S. Iwanaga, A.A. Appiah, T. Ohta, T. Uto, Y. Shoyama, N. Ohta, T.M. Gwira, M. Ohashi, European. J. Med. Plants 25, 1 (2018)
122. I.G. Demarchi, M.V. Thomazella, M.S. de Terron, L. Lopes, Z.C. Gazim, D.A.G. Cortez, L. Donatti, S.M.A. Aristides, T.G.V. Silveira, M.V.C. Lonardoni, Exp. Parasitol. 157, 128 (2015)
123. F.L.S. Da MacHado, W. Pacienza-Lima, B. Rossi-Bergmann, L.M.S. De Gestinari, M.T. Fujii, J.C. Paula, S.S. Costa, N.P. Lopes, C.R. Kaiser, A.R. Soares, Planta Med. 77, 733 (2011)
124. C.B.G. Teles, L.S. Moreira, A.D.A.E. Silva, V.A. Facundo, J.P. Zuliani, R.G. Stábeli, I. Silvm, J. Braz. Chem. Soc. 22, 936 (2011)
125. J.A. Crentsil, L.R.T. Yamthe, B.Z. Anibea, E. Broni, S. K. Kwofie, J.K.A. Tetteh, and D. Osei-Safo, Front. Pharmacol. 11, (2020)
126. A. Das, J.J. Jawed, M.C. Das, P. Sandhu, U.C. De, B. Dinda, Y. Akhter, S. Bhattacharjee, Int. J. Antimicrob. Agents 50, 512 (2017)
127. V.C. Filho, C. Meyre-Silva, R. Niero, L.N. Bolda Mariano, F. Gomes Do Nascimento, I. Vicente Farias, V.F. Gazoni, B. Dos Santos Silva, A. Giménez, D. Gutierrez-Yapu, E. Salamanca, and A. Malheiros, Evidence-Based Complement. Altern. Med. 2013, (2013)
128. B.P. da Silva, D.A. Cortez, T.Y. Violin, B.P.D. Filho, C.V. Nakamura, T. Ueda-Nakamura, I.C.P. Ferreira, Parasitol. Int. 59, 643 (2010)
129. S. Singh, U. Sharma, P. Kumar, D. Singh, M. Dobhal, Indian J. Med. Res. 134, 709 (2011)
130. G. Odonne, G. Herbette, V. Eparvier, G. Bourdy, R. Rojas, M. Sauvain, D. Stien, J. Ethnopharmacol. 137, 875 (2011)
131. J.A. Murillo, J.F. Gil, Y.A. Upegui, A.M. Restrepo, S.M. Robledo, W. Quiñones, F. Echeverri, A.S. Martin, H.F. Olivo, G. Escobar, Bioorganic. Med. Chem. 27, 153 (2019)
132. A. Falodun, V. Imieje, O. Erharuyi, A. Joy, P. Langer, M. Jacob, S. Khan, M. Abaldry, M. Hamann, Doc. Head. Asian Pac J Trop Biomed. 4, 374 (2014)
133. C. Phakeovilay, S. Bourgeade-Delmas, P. Perio, A. Valentin, F. Chassagne, E. Deharo, K. Reybier, G. Marti, Molecules 24, 4536 (2019)
134. C. Bruno de Sousa, K.N. Gangadhar, T.R. Morais, G.A.A. Conserva, C. Vizetto-Duarte, H. Pereira, M.D. Laurenti, L. Campino, D. Levy, M. Uemi, L. Barreira, L. Custódio, L.F.D. Passero, J.H.G. Lago, J. Varela, Exp. Parasitol. 174, 1 (2017)
135. C. Girardi, N. Fabre, L. Paloque, A.P. Ramadani, F. Benoit-Vical, G. González-Aspajo, M. Haddad, E. Rengifo, V. Jullian, J. Ethnopharmacol. 170, 167 (2015)
136. B.B. Cota, L.G. Tunes, D.N.B. Maia, J.P. Ramos, D.M. De Oliveira, M. Kohlhoff, T.M.A. de Alves, E.M. Souza-Fagundes, F.F. Campos, C.L. Zani, Mem. Inst. Oswaldo Cruz 113, 102 (2018)
137. C.R. Novello, E. Düsman, R.B. Balbinot, J.C. de Paula, C.V. Nakamura, J.C.P. de Mello, M.H. Sarragiotto, Nat. Prod. Res. 0, 1 (2020)
138. C.B. Naman, A.D. Gromovsky, C.M. Vela, J.N. Fletcher, G. Gupta, S. Varikuti, X. Zhu, E.M. Zywot, H. Chai, K.A. Werbovetz, A.R. Satoskar, A.D. Kinghorn, J. Nat. Prod. 79, 598 (2016)
139. M.G.F. de Medeiros, A.C. da Silva, A.M.G.L. das Citó, A.R. Borges, S.G. de Lima, J.A.D. Lopes, R.C.B.Q. Figueiredo, Parasitol. Int. 60, 237 (2011)
140. V. Smyrniotopoulos, C. Merten, M. Kaiser, D. Tasdemir, Mar. Drugs 15, 1 (2017)
141. O. Chiboub, I. Sifaoui, J. Lorenzo-Morales, M. Abderrabba, M. Mejri, J.J. Fernández, J.E. Piñero, A.R. Díaz-Marrero, Mar. Drugs 17, 1 (2019).
142. D.C. Soares, M.M. Szlachta, V.L. Teixeira, A.R. Soares, E.M. Saraiva, Mar. Drugs 14, (2016).
143. A.R. Díaz-marrero, A. López-arencibia, C.J. Bethencout-estrella, F. Cen-pacheco, I. Sifaoui, A. Hernández, M.C. Duque-ramírez, I. Universitario, D.B.A. González, I. Ag, C. De Investigaciones, B. De Canarias, U. De La, L. Ull, Bioorg. Chem. 92, (2019)
144. C. Imperatore, R. Gimmelli, M. Persico, M. Casertano, A. Guidi, F. Saccoccia, G. Ruberti, P. Luciano, A. Aiello, S. Parapini, S. Avunduk, N. Basilico, C. Fattorusso, Mar. Drugs 18, (2020).
145. T. Meza-Menchaca, A. Ramos-Ligonio, A. López-Monteon, A.V. Limón, L.A. Kaluzhskiy, T.V. Shkel, N.V. Strushkevich, L.F. Jiménez-García, L.T.A. Moreno, V. Gallegos-García, J. SuárezMedellín, Á. Trigos, Biomolecules 9, (2019).
146. S. Mukherjee, W. Xu, F.F. Hsu, J. Patel, J. Huang, K. Zhang, Mol. Microbiol. 111, 65 (2019)
147. L.P. Borba-Santos, G. Visbal, T. Gagini, A.M. Rodrigues, Z.P. De Camargo, L.M. Lopes-Bezerra, K. Ishida, W. De Souza, S. Rozental, Front. Microbiol. 7, 1 (2016)
148. B. Lomenick, H. Shi, J. Huang, C. Chen, Bioorganic Med. Chem. Lett. 25, 4976 (2015)
149. C. Park, D.O. Moon, C.H. Ryu, B.T. Choi, W.H. Lee, G.Y. Kim, Y.H. Choi, Acta Pharmacol. Sin. 29, 341 (2008)
150. L. Pan, C.M. Lezama-Davila, A.P. Isaac-Marquez, E.P. Calomeni, J.R. Fuchs, A.R. Satoskar, A.D. Kinghorn, Phytochemistry 82, 128 (2012)
151. H.T. Takahashi, E.A. Britta, R. Longhini, T. Ueda-Nakamura, J.C. Palazzo De Mello, C.V. Nakamura, Planta Med. 79, 330 (2013)
152. V. Leliebre-Lara, L.M. Fidalgo, E.M. Pferschy-Wenzig, O. Kunert, C.N. Lima, R. Bauer, Molecules 21, 1045 (2016)
153. E.S. Elkhayat, S.R.M. Ibrahim, G.A. Mohamed, S.A. Ross, Nat. Prod. Res. 30, 814 (2016)
154. G.H. Braun, H.P. Ramos, A.C.B.B. Candido, R.C.N. Pedroso, K.A. Siqueira, M.A. Soares, G.M. Dias, L.G. Magalhães, S.R. Ambrósio, A.H. Januário, R.C.L.R. Pietro, Nat. Prod. Res. 1 (2019)
155. A.A.S. Silva, S.M. Morais, M.J.C. Falcão, I.G.P. Vieira, L.M. Ribeiro, S.M. Viana, M.J. Teixeira, F.S. Barreto, C.A. Carvalho, R.P.A. Cardoso, H.F. Andrade-Junior, Phytomedicine 21, 1419 (2014)
156. L. Keller, J.L. Siqueira-neto, J.M. Souza, K. Eribez, G.M. Lamonte, J.E. Smith, W.H. Gerwick, Molecules 25, 1604 (2020)

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The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

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