Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review

doi:10.1007/s13659-021-00305-0

摘要/Abstract

摘要： Dendrobium Sw. is one of the largest genera in the orchidaceous family and includes 900-2000 species. Among them, more than 80 Dendrobium species have been reported in China. However, there are only six Dendrobium species, namely, D. bigibbum var. superbum (syn. D. phalaenopsis), D. chrysanthum, D. fi mbriatum, D. loddigesii, D. nobile, and D. officinale (syn. D. candidum), listed in the New Inventory of Existing Cosmetic Ingredients in China Launched. Artificial planting of Dendrobium species has been a great success in China. To better utilize Dendrobium resources for medicinal and cosmetic purposes, we summarize their traditional uses and pharmacologically active compounds for treating dermatological disorders in this review. "Orchidaceae", "Dendrobium", "traditional use", "ethnobotany", "dermatological disorder", and "skin disease" were used as search terms to screen the literature. Cited references were collected between 1970 and 2020 from the Web of Science, China National Knowledge Internet (CNKI), SciFinder, Google Scholar, and Chinese books. From the search, it was found that there are 22 Dendrobium species with traditional uses in dermatological disorders, and 131 compounds from Dendrobium plants have been reported to possess anti-inflammatory, antimicrobial, antioxidant, antiaging, anti-psoriasis, and tyrosinase-inhibitory activities, implying that Dendrobium plants are important resources for the discovery of active compounds and the development of new drugs and cosmetics. D. crepidatum, D. denneanum, D. loddigesii, D. nobile, and D. officinale have been extensively studied. More research on other Dendrobium species is needed. The major active compounds found in Dendrobium species are phenanthrenes, alkaloids, flavonoids, phenylpropanoids, and lignans. Several compounds, such as loddigesiinol A, (S)-5-methoxy-2,4,7,9-tetrahydroxy-9,10-dihydrophenanthrene, (S)-4-methoxy-2,5,7,9-tetrahydroxy-9,10-dihydrophenanthrene, 2,5-dihydroxy-4-methoxy-phenanthrene 2-O-β-D-glucopyranoside, (9R)-1,2,5,9-tetrahydroxy-9,10-dihydrophenanthrene 5-O-β-D-glucopyranoside, (+)-homocrepidine A, and vicenin 2, have significant anti-inflammatory activities and inhibit nitric oxide (NO) production with IC₅₀ values less than 5 μM, and these compounds are worthy of further study.

关键词: Orchidaceae, Dendrobium, Traditional uses, Dermatological disorders, Anti-inflammatory

Abstract: Dendrobium Sw. is one of the largest genera in the orchidaceous family and includes 900-2000 species. Among them, more than 80 Dendrobium species have been reported in China. However, there are only six Dendrobium species, namely, D. bigibbum var. superbum (syn. D. phalaenopsis), D. chrysanthum, D. fi mbriatum, D. loddigesii, D. nobile, and D. officinale (syn. D. candidum), listed in the New Inventory of Existing Cosmetic Ingredients in China Launched. Artificial planting of Dendrobium species has been a great success in China. To better utilize Dendrobium resources for medicinal and cosmetic purposes, we summarize their traditional uses and pharmacologically active compounds for treating dermatological disorders in this review. "Orchidaceae", "Dendrobium", "traditional use", "ethnobotany", "dermatological disorder", and "skin disease" were used as search terms to screen the literature. Cited references were collected between 1970 and 2020 from the Web of Science, China National Knowledge Internet (CNKI), SciFinder, Google Scholar, and Chinese books. From the search, it was found that there are 22 Dendrobium species with traditional uses in dermatological disorders, and 131 compounds from Dendrobium plants have been reported to possess anti-inflammatory, antimicrobial, antioxidant, antiaging, anti-psoriasis, and tyrosinase-inhibitory activities, implying that Dendrobium plants are important resources for the discovery of active compounds and the development of new drugs and cosmetics. D. crepidatum, D. denneanum, D. loddigesii, D. nobile, and D. officinale have been extensively studied. More research on other Dendrobium species is needed. The major active compounds found in Dendrobium species are phenanthrenes, alkaloids, flavonoids, phenylpropanoids, and lignans. Several compounds, such as loddigesiinol A, (S)-5-methoxy-2,4,7,9-tetrahydroxy-9,10-dihydrophenanthrene, (S)-4-methoxy-2,5,7,9-tetrahydroxy-9,10-dihydrophenanthrene, 2,5-dihydroxy-4-methoxy-phenanthrene 2-O-β-D-glucopyranoside, (9R)-1,2,5,9-tetrahydroxy-9,10-dihydrophenanthrene 5-O-β-D-glucopyranoside, (+)-homocrepidine A, and vicenin 2, have significant anti-inflammatory activities and inhibit nitric oxide (NO) production with IC₅₀ values less than 5 μM, and these compounds are worthy of further study.

Key words: Orchidaceae, Dendrobium, Traditional uses, Dermatological disorders, Anti-inflammatory

Yue-Hu Wang. Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review[J]. 应用天然产物, 2021, 11(5): 465-487.

Yue-Hu Wang. Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review[J]. Natural Products and Bioprospecting, 2021, 11(5): 465-487.

参考文献

1. R.D. Sontheimer, J. Investig. Dermatol. 134, 581–582 (2014)
2. V.V. Wagh, A.K. Jain, J. Herb. Med. 19, 100234 (2020)
3. P. Bhattacharyya, P. Paul, S. Kumaria, P. Tandon, Acta Physiol. Plant. 40, 137 (2018)
4. S.-G. Zheng, Y.-D. Hu, R.-X. Zhao, S. Yan, X.-Q. Zhang, T.-M. Zhao, Z. Chun, Planta 248, 769–784 (2018)
5. Plants of the World online, http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:325886-2. Accessed on March 4, 2021.
6. CIRS, Inventory of Existing Chemical Ingredient in China. http://www.cirs-reach.com/news-and-articles/new-inventory-of-existing-cosmeticingredients-in-china-launched(iecic-2015,-finalversion).html. Accessed on March 4, 2021. 7. E.S. Teoh, Orchids as Aphrodisiac, Medicine Or Food (Springer, Singapore, 2019), pp. 79–282
8. H.S. Lim, S.R. Yo, M.Y. Lee, C.S. Seo, H.K. Shin, S.J. Jeong, Mol. Med. Rep. 17, 2515–2522 (2018)
9. L. Yang, L.H. Qin, S.A. Bligh, A. Bashall, C.F. Zhang, M. Zhang, Z.T. Wang, L.S. Xu, Bioorg. Med. Chem. 14, 3496–3501 (2006)
10. Y. Hu, J. Ren, L. Wang, X. Zhao, M. Zhang, K. Shimizu, C. Zhang, Phytochemistry 149, 12–23 (2018)
11. Y. Hu, C. Zhang, X. Zhao, Y. Wang, D. Feng, M. Zhang, H. Xie, J. Nat. Prod. 79, 252–256 (2016)
12. Y. Hu, H. Yang, X. Ding, J. Liu, X. Wang, L. Hu, M. Liu, C. Zhang, Bioorg. Chem. 100, 103809 (2020)
13. Y. Lin, F. Wang, L.J. Yang, Z. Chun, J.K. Bao, G.L. Zhang, Phytochemistry 95, 242–251 (2013)
14. D. Yang, Z.Q. Cheng, L. Yang, B. Hou, J. Yang, X.N. Li, C.T. Zi, F.W. Dong, Z.H. Liu, J. Zhou, Z.T. Ding, J.M. Hu, J. Nat. Prod. 81, 227–235 (2018)
15. X.-B. Yang, S. Yan, J.-M. Hu, J. Zhou, Nat. Prod. Res. Dev. 31, 1745–1752 (2019)
16. Editorial Board of Chinese Pharmacopoeia, Chinese Pharmacopoeia (China Medical Science Press, Beijing, 2020), pp. 94–97
17. K.G. Wu, T.H. Li, C.J. Chen, H.I. Cheng, T.Y. Wang, Int. J. Immunopathol. Pharmacol. 24, 367–375 (2011)
18. H. Chen, X. Li, Y. Xu, K. Lo, H. Zheng, H. Hu, J. Wang, Y. Lin, Molecules 23, 1185 (2018)
19. M. Ito, K. Matsuzaki, J. Wang, A. Daikonya, N.L. Wang, X.S. Yao, S. Kitanaka, Chem. Pharm. Bull. 58, 628–633 (2010)
20. X. Li, H. Chen, W. He, W. Yang, F. Ni, Z. Huang, H. Hu, J. Wang, Acta Sci. Nat. Univ. Sunyatseni 58, 96–102 (2019)
21. T.H. Lin, S.J. Chang, C.C. Chen, J.P. Wang, L.T. Tsao, J. Nat. Prod. 64, 1084–1086 (2001)
22. J.S. Hwang, S.A. Lee, S.S. Hong, X.H. Han, C. Lee, S.J. Kang, D. Lee, Y. Kim, J.T. Hong, M.K. Lee, B.Y. Hwang, Bioorg. Med. Chem. Lett. 20, 3785–3787 (2010)
23. X. Zhang, J.K. Xu, J. Wang, N.L. Wang, H. Kurihara, S. Kitanaka, X.S. Yao, J. Nat. Prod. 70, 24–28 (2007)
24. J.H. Kim, S.-Y. Oh, S.-B. Han, G.M. Uddin, C.Y. Kim, J.K. Lee, Arch. Pharm. Res. 38, 1117–1126 (2015)
25. X.F. Zhang, C.H. Zhou, L.K. Zhang, M. Jiang, Z.S. Xie, Y. Yuan, Y.C. Huang, Y.Y. Luo, G. Wei, Chin. J. Exp. Tradit. Med. Formulae 25, 29–34 (2019)
26. J.J. Shie, C.A. Chen, C.C. Lin, A.F. Ku, T.J.R. Cheng, J.M. Fang, C.H. Wong, Org. Biomol. Chem. 8, 4451–4462 (2010)
27. M. Zhang, J. Wu, J. Han, H. Shu, K. Liu, Chem. Cent. J. 12, 109 (2018)
28. V. Kongkatitham, C. Muangnoi, N. Kyokong, W. Thaweesest, K. Likhitwitayawuid, P. Rojsitthisak, B. Sritularak, Phytochem. Lett. 24, 31–38 (2018)
29. B.X. Cai, L.X. Song, H.J. Hu, Z.Z. Han, Y. Zhou, Z.T. Wang, L. Yang, Nat. Prod. Res. (2020). https://doi.org/10.1080/14786
419. 2020. 17824 04
30. C.T. Wu, K.S. Huang, C.H. Yang, Y.C. Chen, J.W. Liao, C.L. Kuo, C.L. Chen, S.F. Lo, C.C. Hsieh, H.S. Tsay, Int. J. Pharm. 463, 193–200 (2014)
31. A. Orchard, S. van Vuuren, Evid. Based Complement. Alternat. Med. 2017, 4517971 (2017)
32. L. He, Q. Su, L. Bai, M. Li, J. Liu, X. Liu, C. Zhang, Z. Jiang, J. He, J. Shi, S. Huang, L. Guo, Eur. J. Med. Chem. 204, 112530 (2020)
33. J. Ren, X.P. Qian, Y.G. Guo, T. Li, S.K. Yan, H.Z. Jin, W.D. Zhang, Phytochem. Lett. 18, 64–67 (2016)
34. F.W. Dong, H.R. Luo, Q.L. Wan, F.Q. Xu, W.W. Fan, K.J. Wang, N. Li, J.M. Hu, Bull. Korean Chem. Soc. 33, 2247–2250 (2012)
35. P. Ouyang, X. He, Z.W. Yuan, Z.Q. Yin, H. Fu, J. Lin, C. He, X. Liang, C. Lv, G. Shu, Z.X. Yuan, X. Song, L. Li, L. Yin, Toxins 10, 385 (2018)
36. X.M. Zhou, B. Zhang, G.Y. Chen, C.R. Han, K.C. Jiang, M.Y. Luo, B.Z. Meng, W.X. Li, S.D. Lin, Nat. Prod. Res. 32, 2464– 2467 (2018)
37. C. Cao, Z. Xiao, Y. Wu, C. Ge, Nutrients 12, 870 (2020)
38. S. Shanbhag, A. Nayak, R. Narayan, U.Y. Nayak, Adv. Pharm. Bull. 9, 348–359 (2019)
39. D. Harman, Proc. Natl. Acad. Sci. USA 78, 7124–7128 (1981)
40. E. Russell-Goldman, G.F. Murphy, Am. J. Pathol. 190, 1356– 1369 (2020)
41. M.R. Poudel, M.B. Chand, N. Karki, B. Pant, Bot. Orient. J. Plant Sci. 9, 20–26 (2015)
42. D. Yang, L.Y. Liu, Z.Q. Cheng, F.Q. Xu, W.W. Fan, C.T. Zi, F.W. Dong, J. Zhou, Z.T. Ding, J.M. Hu, Fitoterapia 100, 11–18 (2015)
43. M.R. Paudel, M.B. Chand, B. Pant, B. Pant, Biomolecules 9, 478 (2019)
44. L. Yang, H. Han, N. Nakamura, M. Hattori, Z. Wang, L. Xu, Phytother. Res. 21, 696–698 (2007)
45. F. Jia, H.L. Xia, Z.J. Ning, P. Huang, X.Y. Huang, J.J. Tang, T.M. Zhang, Sci. Technol. Food Ind. 35, 62–66 (2014)
46. C.B. Singh, M.C. Devi, D.S. Thokchom, M. Sengupta, A.K. Singh, J. Pharmacogn. Phytochem. 4, 6–11 (2015)
47. B. Sritularak, M. Anuwat, K. Likhitwitayawuid, J. Asian Nat. Prod. Res. 13, 251–255 (2011)
48. M. Wei, Y.Y. Liu, W.R. Cai, S.H. Qian, K. Zhang, Food Mach. 32, 136–140 (2016)
49. R.J. Ma, L. Yang, X. Bai, J.Y. Li, M.Y. Yuan, Y.Q. Wang, Y. Xie, J.M. Hu, J. Zhou, Nat. Prod. Bioprospec. 9, 329–336 (2019)
50. S. Yan, R.J. Ma, L. Yang, J.Y. Li, X.B. Yang, J.M. Hu, Nat. Prod. Res. Dev. 31, 615–620 (2019)
51. M.R. Paudel, M.B. Chand, B. Pant, B. Pant, Pharmacogn. J. 9, 499–503 (2017)
52. N.P. Sukumaran, R.H. Yadav, Anc. Sci. Life 35, 240–244 (2016)
53. M.R. Paudel, M.B. Chand, B. Pant, B. Pant, B.M.C. Complement, Altern. Med. 18, 134 (2018)
54. S.F. Lo, V. Mulabagal, C.L. Chen, C.L. Kuo, H.S. Tsay, J. Agric. Food Chem. 52, 6916–6919 (2004)
55. Y. Li, H. Li, X. Ji, Z. Cen, J. Yan, J. Wu, China Pharm. 29, 330–333 (2018)
56. X. Zhang, J.K. Xu, N.L. Wang, H. Kurihara, X.S. Yao, Z. Wang, Chin. Pharm. J. 43, 829–832 (2008)
57. X. Zhang, J.K. Xu, N.L. Wang, H. Kurihara, X.S. Yao, J. Chin. Pharm. Sci. 17, 314–318 (2008)
58. F. Li, Y. Wei, Y. Chen, Acta Chin. Med. 34, 1020–1023 (2019)
59. Q. Huang, Y. Shen, C. Zhang, A. Luo, Y. Fan, Chin. J. Appl. Environ. Biol. 20, 438–442 (2014)
60. J. Wang, H.X. Chen, L.S. Xing, Y.W. Wang, Y.H. Huang, H.Q. Liu, Nat. Prod. Res. Dev. 27, 768–773 (2015)
61. Y. Li, C.L. Wang, Y.J. Wang, S.X. Guo, J.S. Yang, X.M. Chen, P.G. Xiao, Chem. Pharm. Bull. 57, 218–219 (2009)
62. Y. Li, C.L. Wang, Y.J. Wang, F.F. Wang, S.X. Guo, J.S. Yang, P.G. Xiao, Chem. Pharm. Bull. 57, 997–999 (2009)
63. Y. Li, C.L. Wang, H.J. Zhao, S.X. Guo, J. Asian Nat. Prod. Res. 16, 1035–1043 (2014)
64. Y. Li, C.L. Wang, H.J. Zhao, S.X. Guo, Chem. Nat. Compd. 51, 1052–1054 (2015)
65. Y. Li, C.L. Wang, F.F. Wang, H.L. Dong, S.X. Guo, J.S. Yang, P.G. Xiao, Chin. Pharm. J. 45, 975–979 (2010)
66. L.J. Zhu, M.Q. Wang, Y. Qin, M.N. Wang, G.Q. Zhang, L.T. Niu, J.B. Chen, X. Zhang, X.S. Yao, J. Asian Nat. Prod. Res. (2020). https://doi.org/10.1080/10286020.2020.1826937
67. Y. Mai, Z. Niu, W. He, X. Lai, S. Huang, X. Zheng, Biol. Pharm. Bull. 42, 728–735 (2019) 68. H. Li, L.Q. Qian, X. Chen, N.Y. Zhang, S.S. Lei, B. Li, G.Y. Lyu, S.H. Chen, China J. Chin. Mater. Med. 44, 4677–4684 (2019)
69. N. Kyokong, C. Muangnoi, W. Thaweesest, V. Kongkatitham, K. Likhitwitayawuid, P. Rojsitthisak, B. Sritularak, J. Asian Nat. Prod. Res. 21, 391–397 (2019)
70. B. Sritularak, N. Duangrak, K. Likhitwitayawuid, Z. Naturforsch. 66, 205–208 (2011)
71. T. Chimsook, In Phytochemical screening, total phenolic content, antioxidant activities and cytotoxicity of Dendrobium signatum leaves (MATEC Web of Conferences, EDP Sciences, 2016), p. 03005
72. M. Moretti, L. Cossignani, F. Messina, L. Dominici, M. Villarini, M. Curini, M.C. Marcotullio, Food Chem. 140, 660–665 (2013)
73. S.F. Lo, S.M. Nalawade, V. Mulabagal, S. Matthew, C.L. Chen, C.L. Kuo, H.S. Tsay, Biol. Pharm. Bull. 27, 731–735 (2004)
74. P. Rungwichaniwat, B. Sritularak, K. Likhitwitayawuid, Pharmacogn. J. 6, 36–41 (2014)
75. C. Mo, D. Shetti, K. Wei, Molecules 24, 2727 (2019)
76. M. Mingsan, P. Mengfan, L. Dandan, Z. Zhengwang, J. King Saud Univ. Sci. 32, 2669–2674 (2020)
77. L. Guo, J. Qi, D. Du, Y. Liu, X. Jiang, Pharm. Biol. 58, 664–673 (2020)
78. J. Chen, H. Qi, J.B. Li, Y.Q. Yi, D. Chen, X.H. Hu, M.L. Wang, X.L. Sun, X.Y. Wei, China J. Chin. Mater. Med. 39, 291–295 (2014)
79. F.L. Gu, X.P. Jiang, Y.J. Chen, B.X. Han, N.F. Chen, C.B. Wei, Nat. Prod. Res. Dev. 30, 1701–1705 (2018)
80. M. Kanlayavattanakul, T. Pawakongbun, N. Lourith, Chin. Herb. Med. 11, 400–405 (2019)
81. Y.H. Gui, X. Meng, Q.M. Liang, S.Z. Gong, Deterg. Cosmet. 40(22–24), 26 (2017)
82. M. Chen, Y. Sun, Y. Zhao, Acta Univ. Tradit. Med. Sin. Pharmacol. Shanghai 29, 70–73 (2015)
83. Y.J. Ko, S.K. Yang, S.M. Song, W.J. Yoon, K.H. Bae, J. Biol. Act. Prod. Nat. 5, 12–17 (2015)
84. A. Athipornchai, N. Jullapo, S. Afr, J. Bot. 119, 188–192 (2018)
85. N.M. Smith, J. Adelaide Bot. Gard. 14, 1–65 (1991)
86. J. Tucci, S. Wilkens, Aust. J. Rural Health 24, 156–169 (2016)
87. D. Behera, C.C. Rath, U. Mohapatra, Floric Ornam. Biotechnol. 7, 53–59 (2013)
88. U. Barua, D.K. Hore, R.S. Rathi, G. Das, Environ. Ecol. 24, 736–742 (2006)
89. R.K. Maikhuri, P.S. Ramakrishnan, J. Econ. Tax. Bot. 10, 61–78 (1992)
90. A. Subedi, B. Kunwar, Y. Choi, Y. Dai, T. van Andel, R.P. Chaudhary, H.J. de Boer, B. Gravendeel, J. Ethnobiol. Ethnomed. 9, 64 (2013)
91. M. Akhter, M.M. Hoque, M. Rahman, M.K. Huda, J. Med. Plants Stud. 5, 265–268 (2017)
92. W.H. Li, Medical records, In Compilation Committee of Local Records, in Records of Yunnan Province. (Yunnan People’s Publishing House, Kunming, 1995), pp. 960–962
93. H.Y. Zhang, Z.Y. Zhang, Handbook of Traditional Chinese Medicine Resources in China (Science Press, Beijing, 1994), pp. 1531–1536
94. M. Rahamtulla, U.C. Pradhan, A.K. Roy, V. Rampilla, S.M. Khasim, Ethnomedicinal aspects of some orchids from Darjeeling Himalaya, India, in Orchid Biology: Recent Trends & Challenges. ed. by S.M. Khasim, S.N. Hegde, M.T. González-Arnao, K. Thammasiri (Springer, Singapore, 2020), pp. 451–472
95. H. Li, Orchidaceae, in Flora Yunnanica. ed. by Z. Wu (Science Press, Beijing, 2003), pp. 100–819
96. R. Laha, P.C. Lalremruata, R. Vanlalpeka, Int. J. Basic Appl. Res. 8, 371–384 (2018)
97. L.J. Lawler, M. Slaytor, Med. J. Australia 2, 1259–1261 (1970)
98. K. Chowlu, K.S. Mahar, A.K. Das, Indian J. Nat. Prod. Resour. 8, 89–93 (2017)
99. Yunnan Medicinal Materials Company Limited, List of Traditional Chinese Medicine Resources in Yunnan (Science Press, Beijing, China, 1993), pp. 669–672
100. A.P. Tiwari, B. Joshi, A.A. Ansari, Nat. Sci. 10, 33–37 (2012)
101. P.K. Dash, S. Sahoo, S. Bal, Ethnobot. Leaflets 12, 70–78 (2008)
102. S. Jagathes Kumar, R. Ashok Kumar, G. Uma, B. Subbaiyan, V. Aravindhan, V. Balasubramaniam, Int. J. Recent Adv. Multidiscip. Res. 2, 1047–1055 (2015)
103. B. Vaidya, M. Shrestha, N. Joshee, In Report on Nepalese orchid species with medicinal properties, In Proceedings of Nepal-Japan Joint Symposium-2000, Kathmandu, Nepal (The Himalayan plants, can they save us? Proceeding of Nepal-Japan joint symposium on conservation and utilization of Himalayan medicinal resources, 2000), p. 146–152
104. M.M. Hossain, Med. Aromat. Plant Sci. Biotechnol. 3, 100–106 (2009)
105. A.R. Roy, R.S. Patel, V.V. Patel, D.S. Yadav, J. Orchid Soc. India 21, 15–17 (2007)
106. C.R. Deb, M.S. Deb, N.S. Jamir, T. Imchen, Pleione 3, 209–211 (2009)
107. R.P. Medhi, S. Chakrabarti, Indian J. Tradit. Knowl. 8, 11–16 (2009)
108. R. Yonzone, D. Lama, R.B. Bhujel, S. Rai, Indian Forester 140, 413–418 (2014)
109. A.E. Shanavaskhan, M. Sivadasan, A.H. Alfarhan, J. Thomas, Indian J. Tradit. Knowl. 11, 250–258 (2012)
110. Z.Y. Zhu, Q.H. Wei, L. Gao, The Annals of National Medicine in Yunnan (The Nationalities Publishing House of Yunnan, Kunming, 2012), pp. 186–187
111. S. Nurfadilah, IOP Conf. Ser. Earth Environ. Sci. 473, 012063 (2020)
112. J.T. Kpadehyea, E.S. Fernando, C.E. Tinio, I.E. Buot, Electron. J. Biol. 11, 165–175 (2015)

[1]	Qiang Yin, Jianying Han, Guixiang Yang, Zhijun Song, Keke Zou, Kangjie Lv, Zexu Lin, Lei Ma, Miaomiao Liu, Yunjiang Feng, Ronald J. Quinn, Tom Hsiang, Lixin Zhang, Xueting Liu, Guoliang Zhu, Jingyu Zhang. New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus Bipolaris sorokiniana 11134[J]. 应用天然产物, 2025, 15(3): 29-29.
[2]	Hongyan Wen, Sheng Li, Yu Zhang. Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities[J]. 应用天然产物, 2025, 15(3): 26-26.
[3]	Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang. Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway[J]. 应用天然产物, 2024, 14(5): 36-36.
[4]	Shi-Hui Qin, Zhi-Lan Li, Liu Yang, Jiang-Miao Hu. Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata[J]. 应用天然产物, 2024, 14(3): 22-22.
[5]	Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong. Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim[J]. 应用天然产物, 2024, 14(3): 26-26.
[6]	Orawan Jongsomjainuk, Jutatip Boonsombat, Sanit Thongnest, Hunsa Prawat, Paratchata Batsomboon, Sitthivut Charoensutthivarakul, Saroj Ruchisansakun, Kittipong Chainok, Jitnapa Sirirak, Chulabhorn Mahidol, Somsak Ruchirawat. Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis[J]. 应用天然产物, 2023, 13(6): 55-55.
[7]	Yang Yu, Yang Wang, Gui-Chun Wang, Cheng-Yong Tan, Yi Wang, Jin-Song Liu, Guo-Kai Wang. Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity[J]. 应用天然产物, 2023, 13(5): 31-31.
[8]	Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin. New halimane and clerodane diterpenoids from Croton cnidophyllus[J]. 应用天然产物, 2023, 13(3): 21-21.
[9]	Cheng-Yong Tan, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Anti-inflammatory maistemonine-class alkaloids of Stemona japonica[J]. 应用天然产物, 2023, 13(2): 8-8.
[10]	Si, Jia Xiao, Xi, Ke Xu, Wei Chen, Jia, Yun Xin, Wen, Lin Yuan, Xian, Peng Zu, and Yun, Heng Shen. Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control[J]. 应用天然产物, 2023, 13(1): 6-6.
[11]	Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang. Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05[J]. 应用天然产物, 2022, 12(4): 27-27.
[12]	Marsya Yonna Nurrachma, Deamon Sakaraga, Ahmad Yogi Nugraha, Siti Irma Rahmawati, Asep Bayu, Linda Sukmarini, Akhirta Atikana, Anggia Prasetyoputri, Fauzia Izzati, Mega Ferdina Warsito, Masteria Yunovilsa Putra. Cembranoids of Soft Corals: Recent Updates and Their Biological Activities[J]. 应用天然产物, 2021, 11(3): 243-306.
[13]	Xiao-Li Cheng, Han-Xiang Li, Juan Chen, Ping Wu, Jing-Hua Xue, Zhong-Yu Zhou, Nia-He Xia, Xiao-Yi Wei. Bioactive Diarylheptanoids from Alpinia coriandriodora[J]. 应用天然产物, 2021, 11(1): 63-72.
[14]	Yanan Wang, Min Zhang, Xue Zhou, Chengbo Xu, Chenggen Zhu, Yuhe Yuan, Naihong Chen, Yongchun Yang, Qinglan Guo, Jiangong Shi. Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata[J]. 应用天然产物, 2021, 11(1): 31-50.
[15]	Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou. Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity[J]. 应用天然产物, 2021, 11(1): 105-110.